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자외선 B 조사 hairless 마우스에서 일광화상세포 발생 억제에 대한 녹차의 효과
The effect of green tea on ultraviolet B-induced sunburn cell production in the skin of hairless mouse

김성호    (전남대학교 수의과대학   ); 김세라    (전남대학교 수의과대학   ); 이해준    (전남대학교 수의과대학   ); 이진희    (전남대학교 수의과대학   ); 김유진    (전남대학교 수의과대학   ); 김종춘    (전남대학교 수의과대학   ); 장종식    (상주대학교 축산학과   ); 조성기    (한국원자력연구소 방사선이용연구부  );
  • 초록

    In this study we assessed the influences of ultraviolet (UV) light B radiation on epidermal cells by apoptotic sunburn cell (SBC) and the effect of green tea treatment on the inhibition of SBC formation in SKH1-hr mouse. The extent of changes following $200mJ/cm^2$ (0.5 mW/sec) was studied at 0, 3, 6, 12, 18, 24, 30 or 36 hours after exposure. SBCs were recognized by 3 hours after irradiation. There was tendency to increase from 3 hours to 24 hours and decrease from then to 36 hours after irradiation. The mice that received 0, 25, 50, 100, 200, 400 or $800mJ/cm^2$ of UVB were examined 24 hours after irradiation. The SBCs were induced as the radiation dose increases from 0 to $200mJ/cm^2$ . A further increase of radiation dose has little further effect. The frequency of UVB ( $200mJ/cm^2$ )-induced SBC formation was reduced by intraperitoneal injection of green tea extract (p


  • 주제어

    ultraviolet B .   sunburn cell .   SKH1-hr mouse .   green tea.  

  • 참고문헌 (36)

    1. 김세라, 이해준, 김성호. 감마선 조사 마우스에서 녹차 및 분획의 방사선 장해 경감 효과, 대한수의학회지 2003, 43, 633-639 
    2. Gilchrest BA, Soter NA, Stoff JS, Mihm MCJr. The human sunburn reaction: histologic and biochemical studies. J Am Acad Dermatol 1981, 5, 411-422 
    3. Guo Q, Zhao B, Li M, Shen S, Xin W. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim Biophys Acta 1996, 1304, 210-222 
    4. Johnson BE, Mandell G, Daniels FJr. Melanin and cellular reactions to ultraviolet radiation. Nat New Biol 1972, 235, 147-149 
    5. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26, 239-257 
    6. Logan G, Wilhelm DL. Vascular permeability changes in inflammation. I. The role of endogenous permeability factors in ultraviolet injury. Br J Exp Pathol 1966, 47, 300-314 
    7. Matsumura Y, Ananthaswamy HN. Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol 2004, 195, 298-308 
    8. Wang ZY, Agarwal R, Bickers DR, Mukhtar H. Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols. Carcinogenesis 1991, 12, 1527-1530 
    9. Willis I. Sunburn and sunscreen. Unit 19-6, 11th ed, Harper & Row, Philadelphia, 1984 
    10. Cotelle N, Bernier JL, Henichart JP, Catteau JP, Gaydou E, Wallet JC. Scavenger and antioxidant properties of ten synthetic flavones. Free Radic Biol Med 1992, 13, 211-219 
    11. Kim SH, Kim SR, Lee HJ, Oh H, Ryu SY, Lee YS, Kim TH, Jo SK. Apoptosis in growing hair follicles following gamma-irradiation and application for the evaluation of radioprotective agents. In Vivo 2003, 17, 211-214 
    12. Bissett DL, Hannon DP, Orr TV. An animal model of solar-aged skin: histological, physical, and visible changes in UV-irradiated hairless mouse skin. Photochem Photobiol 1987, 46, 367-378 
    13. Nix TE, Nordquist RE, Everett MA. Ultrastructural changes induced by ultraviolet light in human epidermis: granular and transitional cell layers. J Ultrastruct Res 1965, 12, 547-573 
    14. Obata M, Tagami H. Alteration in murine epidermal Langerhans cell population by various UV irradiations: quantitative and morphologic studies on the effects of various wavelengths of monochromatic radiation on Iabearing cells. J Invest Dermatol 1985, 84, 139-145 
    15. Rosario R, Mark GJ, Parrish JA, Mihm MCJr. Histological changes produced in skin by equally erythemogenic doses of UV-A, UV-B, UV-C and UVA with psoralens. Br J Dermatol 1979, 101, 299-308 
    16. Olson RL, Everett MA. Epidermal apoptosis: cell deletion by phagocytosis. J Cutan Pathol 1975, 2, 53-57 
    17. Fujiki H, Suganuma M, Imai K, Nakachi K. Green tea: cancer preventive beverage and/or drug. Cancer Lett 2002, 188, 9-13 
    18. Mitscher LA, Jung M, Shankel D, Dou JH, Steele L, Pillai SP. Chemoprotection: a review of the potential therapeutic antioxident properties of green tea (Camellia sinensis) and certain its constituents. Med Res Rev 1997, 17, 327-365 
    19. Clydesdale GJ, Dandie GW, Muller HK. Ultraviolet light induced injury: immunological and inflammatory effects. Immunol Cell Biol 2001, 79, 547-568 
    20. Dufresne CJ, Farnworth ER. A review of latest research findings on the health promotion properties of tea. J Nutr Biochem 2001, 12, 404-421 
    21. Woodcock A, Magnus IA. The sunburn cell in mouse skin: preliminary quantitative studies on its production. Br J Dermatol 1976, 95, 459-468 
    22. 조광열, 윤재일, 이유신. 자외선 조사에 의한 생쥐 피부에서의 일광화상세포의 정량적 변화. 대한피부과학회지 1986, 24, 8-15 
    23. Godar DE. Preprogrammed and programmed cell death mechanisms of apoptosis: UV-induced immediate and delayed apoptosis. Photochem Photobiol 1996, 63, 825-830 
    24. Lu YP, Lou YR, Li XH, Xie JG, Brash D, Huang MT, Conney AH. Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice. Cancer Res 2000, 60, 4785-4791 
    25. Record IR, Dreosti IE. Protection by black tea and green tea against UVB and UVA + B induced skin cancer in hairless mice. Mutat Res 1998, 422, 191-199 
    26. Svobodova A, Psotova J, Walterova D. Natural phenolics in the prevention of UV-induced skin damage. A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2003, 147, 137-145 
    27. Weisburger JH. Tea and health: the underlying mechanism. Proc Soc Exp Biol Med 1999, 220, 271-275 
    28. 이은희, 이종권, 홍진태, 정경미, 김용규, 이선희, 정수연, 이용욱. 녹차추출물 성분 catechin이 자외선에 의해 손상된 피부에 미치는 영향. 한국식품위생안전성학회지 2001, 16, 117-124 
    29. Aberer W, Schuler G, Stingl G, Honigsmann H, Wolff K. Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 1981, 76, 202-210 
    30. Cooper KD, Duraiswamy N, Hammerberg C, Allen E, Kimbrough-Green C, Dillon W, Thomas D. Neutrophils, differentiated macrophages, and monocyte/macrophage antigen presenting cells infiltrate murine epidermis after UV injury. J Invest Dermatol 1993, 101, 155-163 
    31. Daniels F, Brophy D, Lobitz WC. Histochemical responses of human skin following ultraviolet irradiation. J Invest Dermatol 1961, 37, 351-357 
    32. Sato T, Miyata G. The nutraceutical benefit, part I: green tea. Nutrition 2000, 16, 315-317 
    33. Zloch Z. The role of dietary plant polyphenols in health maintenance. Cas Lek Cesk 1996, 135, 84-88 
    34. 김세라, 이해준, 김휴경, 이진희, 오기석, 박인철, 오헌, 조성기, 김성호. 감마선을 조사 한 마우스에서 녹차 장기투여의효과. 한국임상수의학회지 2003, 20, 159-165 
    35. Dreosti IE. Bioactive ingredients: antioxidants and polyphenols in tea. Nutr Rev 1996, 54, S51-58 
    36. Yoshioka H, Akai G, Yoshinaga K, Hasegawa K, Yoshioka H. Protecting effect of a green tea percolate and its main constituents against gamma ray-induced scission of DNA. Biosci Biotechnol Biochem 1996, 60, 117-119 
  • 이 논문을 인용한 문헌 (1)

    1. Lee, Hyun-Hwa ; Song, Seon-Young 2010. "A Study of Effectiveness of Lithospermum erythrorhizon Extracts on the Skin by UVB-Irradiation C57BL/6 Mouse" 한국현미경학회지 = Korean journal of microscopy, 40(3): 139~145     

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