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Potentially Cytotoxic Triterpenoids from the Root Bark of Siphonodon celastrineus Griff.

Niampoka, Chokchai    (Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University   ); Suttisri, Rutt    (Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University   ); Bavovada, Rapepol    (Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University   ); Takayama, Hiromitsu    (Faculty of Pharmaceutical Sciences, Chiba University   ); Aimi, Norio    (Faculty of Pharmaceutical Sciences, Chiba University  );
  • 초록

    A new oleanane-triterpene, 3 ${\beta}$ -acetoxy-11 ${\alpha}$ -benzoyloxy-13 ${\beta}$ -hydroxyolean-1 2-one (1), was isolated along with a known quinone-methide triterpene, pristimerin (2), from the root bark of Siphonodon celastrinneus Griff., a Thai medicinal plant of the family Celastraceae. Their structures were determined based on spectroscopic analysis.


  • 주제어

    Siphonodon celastrineus .   Celastraceae .   Oleanane-triterpene .   Quinone-methide triterpene.  

  • 참고문헌 (11)

    1. Ankli, A., Heilmann, J., Heinrich, M., and Sticher, O., Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri. Phytochem., 54, 531-537 (2000) 
    2. Herath, H. M. T. B., Athukoralage, P. S., and Jamie, J. F., Two oleanane triterpenoids from Gordonia ceylanica and their conversions to taraxarane triterpenoids. Phytochem., 54, 823-827 (2000) 
    3. Avilla, J., Teixido, A., Velazquez, C., Alvarenga, N., Ferro, E., and Canela, R., Insecticidal activity of Maytenus species (Celastraceae) nortriterpene quinone methides against codling moth, Cydia pomonella (L.) (Lepidoptera: tortricidae). J. Agric. Food Chem., 48, 88-92 (2000) 
    4. Chang, F. R., Hayashi, K., Chen, I. H., Liaw, C. C., Bastow, K. F., Nakanishi, Y., Nozaki, H., Cragg, G. M., Wu, Y. C., and Lee, K. H., Antitumor agents 228. Five new agarofurans, reissantins A-E, and cytotoxic principles from Reissantia buchananii. J. Nat. Prod., 66, 1416-1420 (2003) 
    5. Dirsch, V. M., Kiemer, A. K., Wagner, H., and Vollmar, A. M., The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur. J. Pharmacol., 336, 211-217 (1997) 
    6. Calzada, F., Mata, R., Lopez, R., Lineres, E., Bye, R., Barreto, V. M., and del Rio, F., Friedelanes and triterpenoid quinonemethide from Hippocratea excelsa. Planta Med., 57, 194-195 (1991) 
    7. Chayamarit, K., Thai Medicinal Plants, Part 4, Chutima Publishing, Bangkok, pp. 330-332 (1985) 
    8. Itokawa, H., Qiao, Y.-F., Takeya, K., and Iitaka, Y., New triterpenoids from Rubia cordifolia var. pratensis (Rubiaceae). Chem. Pharm. Bull., 37, 1670-1672 (1989) 
    9. Brown, P. M., Moir, M., Thonson, R. H., King, T. J., Krishnamoorthy, V., and Seshadri, T. R., Tingenone and hydroxytingenone, triterpenoid quinone methides from Euonymus tingens. J. Chem. Soc., Perkin Trans., 1, 2721- 2725 (1973) 
    10. Itharat, A., Houghton, P. J., Eno-Amooquaye, E., Burke, P. J., Sampson, J. H., and Raman, A., In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. J. Ethnopharmacol., 90, 33-38 (2004) 
    11. Dirsch, V., Wiemann, W., and Wagner, H., Antiinflammatory activity of triterpene quinone-methides and proanthocyanidins from the stem bark of Heisteria pallida. Engl. Pharm. Pharmacol. Lett., 2, 184-186 (1992) 

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