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Journal of microbiology and biotechnology v.15 no.1, 2005년, pp.1 - 6   피인용횟수: 1

Optimal Criterion for the Scale-Up Production of Schizophyllan in the Stirred Tank Reactor

KWAK, JUNG-KI    (Institute for Biotechnology, Technical University of Berlin   ); KOO, JAE-GUEN    (College of Ocean Science and Technology, Kunsan University   ); PARK, SUNG-WOO    (College of Ocean Science and Technology, Kunsan University   ); CHO, MAN-GI    (Engineering Research Center, Dongseo University   ); KANG, BYEONG-CHUL    (Engineering Research Center, Dongseo University   ); RAINER BUCHHOLZ    (Institute for Biotechnology, Technical University of Berlin   ); PETER GOETZ    (Institute for Biotechnology, Technical University of Berlin  );
  • 초록

    Optimal criterion for the scale-up production of schizophyllan, a fungal polysaccharide secreted by Schizophyllum commune, was investigated. For the production of the polysaccharide in a 150-l bioreactor, the culture conditions optimized in a 15-l bioreactor were applied to a 150-l bioreactor with scale-up process, by changing impeller speed and airflow rate. The optimized impeller speed in the 15-l bioreactor was 50 rpm in a technical medium based on barley. For establishment of the scale-up process, 3 kinds of criteria were used while the gas throughput number was kept constant, as follows; constant volume-related power input, constant tip speed of stirrer, and constant Reynolds number. In the 150-l bioreactor, the highest values for the maximum specific growth rate (1.17/day) and productivity (0.63 g/L ${\cdot}$ day) were achieved in the culture condition from constant volumerelated power input criterion.


  • 주제어

    Scale-up process .   schizophyllan .   gas throughputnumber .   volume related power input .   tip speed of stirrer .   Reynolds number.  

  • 참고문헌 (20)

    1. Fincher, G. B. 1975. Morphology and chemical composition of barley endosperm cell walls. J. Inst. Brew. 81: 116 
    2. Goetz, P. 1994. Mikrobielle produktion und aufarbeitung des polysaccharids schizophyllan; methoden der biotechnologie. Gustav Fisher 182- 186 
    3. Kim, J.-M., J.-E. Shin, M. J. Han, S.-H. Park, and D.-H. Kim. 2003. Inhibitory effect of ginseng saponins and polysaccharides on infection and vacuolation of Helicobacter pylori. J. Microbiol. Biotechnol. 13: 706- 709     
    4. Rau, U., E. Gura, E. Olszewski, and F. Wagner. 1992. Enhanced glucan formation of filamentous fungi by effective mixing, oxygen limitation and fed-batch processing. J. Industrial Microbiol. 9: 19- 26 
    5. Schilling, B. M., U. Rau, T. Maier, and P. Frankhauser. 1999. Modeling and scale-up of the unsterile scleroglucan production process with Sclerotium rolfsii ATCC 15205. Bioprocess Bioeng. 20: 195- 201 
    6. Theander, O. and E. A. Westerlund. 1986. Studies on dietary fiber. 3. Improved procedures for analysis of dietary fiber. J. Agric. Food Chem. 34: 330 
    7. Engstad, R. E., B. Robertsen, and E. Frivoid. 1992. Yeast glucan induced increase in activity of lysozyme and complement-mediated heamolytic activity in Atlantic salmon blood. Fish Shellfish Immunol. 2: 287- 297 
    8. Grisel, M. and G. Muller. 1998. Rheological properties of the schizophyllan-borax system. Macromolecules 31: 4277-4281 
    9. Yuchun, W. and B. McNeil. 1996. Scleroglucan. Crit. Rev. Biotechnol.16(3): 185-215 
    10. Rau, R.-J., K. Muller, K. Cordes, and J. Klein. 1990. Process and molecular data of branches 1,3-${\beta}$-D-glucan in comparison with xanthan. Bioproc. Eng. 5: 89- 93 
    11. Rorstad, G., P. Aasjord, and B. Robertsen. 1993. Adjuvant effect of yeast glucan in vaccines against furunculosis in atlantic salmon (Salmo salar L.). Fish Shellfish Immunol. 3: 179-190 
    12. Lee, J. H., J. H. Kim, M. R. Kim, S. M. Lim, S. W. Nam, J. W. Lee, and S. K. Kim. 2002. Effect of dissolved oxygen concentration and pH on the mass production of high molecular weight pullulan by Aureobasidium pullulans. J. Microbiol. Biotechnol. 12: 1s-7s 
    13. Kim, S. K., C.-G. Lee, and H. S. Yun. 2003. Heavy metal adsorption characteristics of extracellular polysaccharide produced by Zoogloea ramigera grown on various carbon sources. J. Microbiol. Biotechnol. 13: 745- 750     
    14. Kwak, J. K., J. H. Park, J. S. Lee, P. Goetz, and M. G. Cho. 1999. Production of extracellular polysaccharide by Monilinia fructigena for aquaculture. J. Fish. Sci. Tech. 2: 182- 188 
    15. Nienow, A. W. 1990. Agitators for mycelial fermentation. Trends Biotechnol. 8: 224- 233 
    16. Kikumoto, S., T. Miyajirna, S. Yoshizumi, S. Fusimoto, and K. Kimura. 1970. Polysaccharide produced by Schirophyllum commune. Formation and some properties of an extracellular polysaccharide. Nippon Nogei Kagaku Kaishi 44: 337 - 342 
    17. Williams, D. L., A. Mueller, and W. Browder. 1996. Glucan-based macrophage stimulators. A review of their antiinfective potential. Clinical Immunotherapy 5: 392- 399 
    18. Santamaria, F, F Reyes, and R. Lahoz. 1978. Extracellular glucan containing (13)- and (16)-linkages isolated from Moniliniafructigena. J. Gen. Microbiol. 109: 287- 293 
    19. Zhang, X.-H., H.-B. Hu, Y.-L. Tang, R.-S. Huang, J.-F Luo, and B.-K. Hur. 2002. The hepatoprotective effects of polysaccharides isolated from submerged fermentation of Ganoderma lucidum. J. Microbiol. Biotechnol. 12: 367-370     
    20. Sung, H. H., G. Kou, and Y. L. Song. 1994. Vibriosis resistance induced by glucan treatment in tiger shrimp (Penaeus monodon). Fish Pathology 29(1): 11- 17 
  • 이 논문을 인용한 문헌 (1)

    1. Yang, Yoon Kyoung ; Wang, Lin ; Kwon, Oran 2014. "Protective effects of Acanthopanax koreanum Kakai extract against carbon tetrachloride-induced liver injury in Sprague-Dawley rats" Journal of nutrition and health, 47(2): 106~112     

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