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Journal of microbiology and biotechnology v.15 no.1, 2005년, pp.112 - 117   피인용횟수: 2

Griseofulvin from Xylaria sp. Strain F0010, an Endophytic Fungus of Abies holophylla and its Antifungal Activity Against Plant Pathogenic Fungi

PARK, JOONG-HYEOP    (Biological Function Research Team, Korea Research Institute of Chemical Technology   ); CHOI, GYUNG-JA    (Biological Function Research Team, Korea Research Institute of Chemical Technology   ); LEE, SEON-WOO    (School of Biological Sciences, Seoul National University   ); LEE, HYANG-BURM    (School of Biological Sciences, Seoul National University   ); KIM, KYOUNG-MO    (School of Biological Sciences, Seoul National University   ); JUNG, HACK-SUNG    (Biological Function Research Team, Korea Research Institute of Chemical Technology   ); JANG, KYOUNG-SOO    (Biological Function Research Team, Korea Research Institute of Chemical Technology   ); CHO, KWANG-YUN    (Biological Function Research Team, Korea Research Institute of Chemical Technology   ); KIM, JIN-CHEOL    (Biological Function Research Team, Korea Research Institute of Chemical Technology  );
  • 초록

    Abstract Griseofulvin has been used as an antifungal antibiotic for the treatment of mycotic diseases of humans and veterinary animals. The purpose of this work was to identify a griseofulvin-producing endophytic fungus from Abies holophylla and evaluate its in vivo antifungal activity against plant pathogenic fungi. Based on nuclear ribosomal ITS1-5.8SITS2 sequence analysis, the fungus was identified and labeled as Xylaria sp. F0010. Two antifungal substances were purified from liquid cultures of Xylaria sp. F0010, and their chemical identities were determined to be griseofulvin and dechlorogriseofulvin through mass and NMR spectral analyses. Compared to dechlorogriseofulvin, griseofulvin showed high in vivo and in vitro antifungal activity, and effectively controlled the development of rice blast (Magnaporthe grisea), rice sheath blight (Corticium sasaki), wheat leaf rust (Puccinia recondita), and barley powdery mildew (Blumeria graminis f. sp. hordei), at doses of 50 to 150 ${\mu}$ g/ml, depending on the disease. This is the first report on the production of griseofulvin and dechlorogriseofulvin by Xylaria species.

  • 주제어

    Antifungal activity .   endophyte .   dechlorogriseofulvin.  

  • 참고문헌 (32)

    1. Kim, J.-C., G. J. Choi, J.-H. Park, H. T. Kim, and K. Y. Cho. 2001. Activity against plant pathogenic fungi of phomalactone isolated from Nigrospora sphaerica. Pest Manag. Sci. 57: 554-559 
    2. Kim, J.-C., G. J. Choi, S.-W. Lee, J.-S. Kim, K. Y. Chung, and K. Y. Cho. 2004. Screening extracts of Achyranthes japonica and Rumex crispus for activity against various plant pathogenic fungi and control of powdery mildew. Pest Manag. Sci. 60: 803- 808 
    3. Park, J.-H., J. H. Park, G. J. Choi, S.-W. Lee, K. S. Jang, Y. H. Choi, K. Y. Cho, and J.-C. Kim. 2003. Screening for antifungal endophytic fungi against six plant pathogenic fungi. Mycobiology 31: 179- 182     
    4. Rodrigues, K. F. 1994. The foliar fungal endophytes of the Amazonian palm Euterpe oleracea. Mycologic 86: 376-385 
    5. Swofford, D. L. 2002. PAUP: Phylogenetic Analysis Using Parsimony, Version 4.0b10. Illinois Natural History Survey, Champaign, IL, U.S.A. 
    6. Yamaguchi, I. 1995. Antibiotics as antifungal agents, pp. 415- 429. In H. Lyr (ed.), Modern Selective FungicidesProperties, Applications, Mechanisms of Action. Gustav Fischer Verlag, Suite, New York, U.S.A. 
    7. Lodge, D. J., P. J. Fisher, and B. C. Sutton. 1996. Endophytic fungi of Manilkara bidentata leaves in Puerto Rico. Mycologia 88: 733- 738 
    8. Mantle, P. G., J. Laws, M. J. Tan, and M. Tizard. 1984. A novel process for the production of penitrem mycotoxins by submerged fermentation of Penicillium nigricans. J. Gen. Microbiol. 130: 1293- 1298 
    9. Davidse, L. C. 1986. Benzimidazole fungicides: Mechanism of action and biological impact. Annu. Rev. Phytopathol. 24: 43- 65 
    10. Gooday, G. W. 1990. Inhibition of chitin metabolism, pp. 61- 80. In P. J. Kuhn, A. P. J. Trinci, M. L. Jung, M. W. Gosey, and L. G. Copping (eds.), Biochemistry of Cell Walls and Membranes in Fungi. Springer-Verlag, Heidelberg, Germany 
    11. Richardson, K. A. and R. S. Currah. 1995. The fungal community associated with the roots of some rainforest trees in Puerto Rico. J. Ind. Microbiol. 17: 284- 294 
    12. Rodrigues, K. F. and G. Samuels. 1990. Preliminary study of endophytic fungi in a tropical palm. Mycol. Res. 94: 827-830 
    13. David, G. J. K. and N. H. Paul. 1976. Metabolites of Aspergillus versicolor: 6,8-di-O-methylnidurufin, griseofulvin, dechlorogriseofulvin, and 3,8-dihydroxy-6-methoxy-l-methylxanthone. Phytochemistry 15: 1037- 1039 
    14. Grove, J. F., J. Macmillan, T. P. C. Mulholland, and M. A. T. Rodgers. 1952. Griseofulvin. Int. J. Chem. Soc. 3949- 3958 
    15. Venkata Dasu, V., T. Panda, and M. Chidanbram. 2002. Development of medium for griseofulvin production: Part II. Optimization of medium constituents using central composite design. J. Microbiol. Biotechnol. 12: 360- 366     
    16. Isaka, M., A. Jaturapat, W. Kladwang, J. Punya, Y. Lertwerawat, M. Tanticharoen, and Y. Thebtaranonth. 2000. Antiplasmodial compounds from the wood-decayed fungus Xylaria sp. BCC1067. Planta Med. 66: 473- 475 
    17. Venkata Dasu, V., T. Panda, and M. Chidanbram. 2002. Development of medium for griseofulvin production: Part I. Screening of medium constituents using the PlackettBurman experimental design. J. Microbiol. Biotechnol. 12: 355- 359     
    18. White, T. J., T. Bruns, S. Lee, and J. W. Taylor. 1990. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics, pp. 315- 322. In M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White (eds.), PCR Protocols: A Guide to Methods and Application. Academic Press, San Diego, CA, U.S.A. 
    19. Hall, T. A. 1999. BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/ NT. Nucl. Acids Symp. Ser. 41: 95- 98 
    20. Lednicer, D. and L. A. Mitscher. 1977. The Organic Chemistry of Drug Synthesis, pp. 313- 317. John Wiley and Sons, New York, U.S.A. 
    21. Lin, Y., X. Wu, S. Feng, G. Jiang, J. Luo, S. Zhou, L. L. P. Vrijrnoed, E. B. G. Jones, K. Kronhn, K. Steingrover, and F. Zsila. 2001. Five unique compounds: Xyloketals from mangrove fungus Xylaria sp. from the South China sea coast. J. Org. Chem. 66: 6252- 6256 
    22. Dhingra, O. D. and J. B. Sinclair. 1986. Basic Plant Pathology, pp. 227- 243. CRC Press, Boca Raton, Florida, U.S.A. 
    23. Bayman, P., L. L. Lebron, R. L. Tremblay, and D. J. Lodge. 1997. Variation in endophytic fungi from roots and leaves of Lepanthes (Orchidaceae). New Phytologist 135: 143- 149 
    24. Bayman, P., P Angulo-Sandoval, Z. Baez-Ortiz, and D. J. Lodge. 1998. Distribution and dispersal of Xylaria endophytes in two tree species in Puerto Rico. Mycol. Res. 102: 944- 948 
    25. Dreyfuss, M. and O. Petrini. 1984. Further investigation on the occurrence and distribution of endophytic fungi in tropical plants. Botanica Helvetica 94: 33- 40 
    26. Whalley, A. J. S. 1996. The xylariaceous way of life. Mycol. Res. 100: 897- 922 
    27. Yoshihiro, S., A. Yorika, and O. Taiko. 1978. Biosynthetic studies of griseofulvin: Experimental using unnatural compounds as substrates. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 21: 152- 158 
    28. Terekhova, L. P., O. A. Galatenko, V. V. Kulyaeva, I. V. Tolstykh, T. P. Golova, and G. S. Katrukha. 1992. Formation of griseofulvin and ethamycin by the new producer Streptomyces albolongus. Antibiotiki I Khimioterapita 37: 19- 21 
    29. Smith, C. J., N. R. Morin, G. F. Bills, A. W. Dombrowski, G. M. Salitura, S. K. Smith, A. Zhao, and D. J. MacNeil. 2002. Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor. J. Org. Chem. 67: 5001-5004 
    30. Thompson, J. D., T. J. Gibsori., F. Plewniak, F. Jeanmougin, and D. G. Higgin. 1997. The Clustal X windows interface: Flexible strategies for 'multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 24: 4876- 4882 
    31. Boonphong, S., P Kittakoop, M. Isaka, D. Pittayakhajonwut, M. Tanticharoen, and Y. Thebtaranonth. 2001. Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex. J. Nat. Prod. 64: 965- 967 
    32. Rodgers, J. D. 1979. The Xylariaceae: Systematic, biological and evolutionary aspects. Mycologia 71: 1- 41 
  • 이 논문을 인용한 문헌 (2)

    1. 2006. "" Journal of microbiology and biotechnology, 16(3): 465~468     
    2. 2007. "" Journal of microbiology and biotechnology, 17(9): 1568~1572     

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