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Journal of microbiology and biotechnology v.15 no.1, 2005년, pp.136 - 140   피인용횟수: 5

Hypoglycemic Effect of Collybia confluens Exobiopolymer Produced by Submerged Mycelial Culture on Diabetic Rats

YANG, BYUNG-KEUN    (School of Science, Food & Horticulture, University of Western Sydney   ); LEE, HYUN-JI    (Department of Biotechnology, Daegu University   ); JEONG, SANG-CHUL    (Department of Biotechnology, Daegu University   ); LIM, WANG-JIN    (School of Life Sciences and Biotechnology, Korea University   ); SONG, CHI-HYUN    (Department of Biotechnology, Daegu University  );
  • 초록

    The hypoglycemic effect of Collybia confluens exobiopolymer was investigated in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, the exobiopolymer, at 150 mg/kg body weight (BW) dose substantially lowered the plasma glucose level by 29.3%, as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 23.3 and 30.7%, respectively, and reduced the liver total cholesterol and triglyceride levels by 23.0 and 33.5%, respectively. The activity of alanine transaminase (ALT) and aspartate transaminase (AST) was reduced 34.6% and 23.6% respectively, by the exobiopolymer administration, compared to the control group. The exobiopolymer was found to contain 83.2% carbohydrate and 16.8% protein. The sugar and amino acid of the exobiopolymer were also analyzed in detail.


  • 주제어

    Collybia confluens .   exobiopolymer .   hypoglycemic .   effect .   submerged mycelial culture.  

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  • 이 논문을 인용한 문헌 (5)

    1. 2006. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 29(1): 73~79     
    2. 2006. "" Journal of microbiology and biotechnology, 16(8): 1240~1247     
    3. 2007. "" Journal of microbiology and biotechnology, 17(12): 2005~2017     
    4. 2008. "" Journal of microbiology and biotechnology, 18(3): 560~567     
    5. 2008. "" Journal of microbiology and biotechnology, 18(8): 1431~1438     

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