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Antiinflammatory Constituents from the Roots of Smilax bockii warb.

Xu Jing    (Research Department of Natural Medicine, Shenyang Pharmaceutical University   ); Li Xian    (Research Department of Natural Medicine, Shenyang Pharmaceutical University   ); Zhang Peng    (Research Department of Natural Medicine, Shenyang Pharmaceutical University   ); Li Zhan-Lin    (Research Department of Natural Medicine, Shenyang Pharmaceutical University   ); Wang Yi    (Research Department of Natural Medicine, Shenyang Pharmaceutical University  );
  • 초록

    From $70\%$ ethanol extract of the roots of Smilax bockii warb., seven flavonoids, kaempferol (1), $kaempferol-7-O-\beta-D-glucopyranoside$ (2), quercetin (3), isorhamnetin (4), (+)-dihydro­kaempferol (5), engeletin (6), isoengeletin (7), and $n-butyl-\beta-D-fructopyranoside$ (8), caffeic acid n-butyl ester (9) were isolated and identified by means of chemical and spectroscopic. Compounds 2, 4, and 6-9 were isolated for the first time from the roots of S. bockii and compounds 2, 8, and 9 were firstly isolated from the genus Smilax. In addition, using the SEAP (Secreted alkaline phosphatase) assay system, we investigated the in vitro anti-inflammatory activity of the $70\%$ ethanol extract of the roots of S. bockii, which showed moderate activity in inhibiting $TNF-\alpha-induced NF-{\kappa}B$ activation with an $IC_{50}$ value of $166.6 {\mu}g/mL$ .


  • 주제어

    Smilax bockii warb.   .   Flavonoids .   Caffeic acid n-butyl ester .   Anti-inflammation activity.  

  • 참고문헌 (11)

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    8. Haraguchi, Y., Yagi, A., and Koda, A., A specific inhibitor of IgEantibody formation: $n-butyl-\alpha-D-fructopyranoside$. J. Med. Chem., 25, 149 (1982) 
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  • 이 논문을 인용한 문헌 (1)

    1. 2006. "" Natural product sciences, 12(2): 101~103     

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