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개 코로나바이러스 불활화 백신에 대한 개와 기니픽 간의 면역반응 비교
Comparison of immune responses of dogs and guinea pigs inoculated with inactivated canine coronavirus vaccines

안동준    (농림부 국립수의과학검역원   ); 김병한    (농림부 국립수의과학검역원   ); 정병열    (농림부 국립수의과학검역원   ); 이철현    (농림부 국립수의과학검역원   ); 전우진    (농림부 국립수의과학검역원   ); 이필수    (농림부 국립수의과학검역원   ); 정갑수    (농림부 국립수의과학검역원  );
  • 초록

    Canine coronavirus (CCV) causes a mild gastroenteritis in dogs. The virus is highly contagious. Although the virus was isolated more than thirty years ago, canine coronavirus infection continues to be a widespread problem. Mixed infections with both CCV and canine parvovirus (CPV) are common. Four kinds of commercial killed CCV vaccines are available in Korea. All the commercial vaccines should pass the National Assay for Veterinary Biologicals prior to release. For the potency test of CCV vaccine, it is necessary to use CCV antibody free dogs. The test requires not only kennels but high cost. To develop easy, efficient and economic potency test method for killed CCV vaccine using laboratory animals, a series of experiments with rabbits and guinea pigs were carried out in this study. In the preliminary test, the guinea pigs showed better immune responses than rabbits. The guinea pig was also easy to manage. So guinea pig was selected for the potency test animals. When the guinea pigs were inoculated twice with one dose of vaccine intramuscuarly each, slower and a little lower SN antibody titers were induced in guinea pigs than in dogs (about 2 kg body weight Beagle strain) given the same posology as guinea pigs'. It was concluded that guinea pigs could be substituted for dogs in the potency test of killed CCV vaccine.


  • 주제어

    canine coronavirus .   inactivated vaccine.  

  • 참고문헌 (29)

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