본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

A case of chronic lymphocytic leukemia (CLL) in a Maltese dog

Lee, Ji-Yun    (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University   ); Hong, Eun-Sil    (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University   ); Kang, Byeong-Teck    (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University   ); Jung, Dong-in    (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University   ); Park, Chul    (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University   ); Park, Hee-Myung    (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University  );
  • 초록

    An 11-year-old, 3.3 kg, male Maltese dog was referred to Veterinary Teaching Hospital of Konkuk University because of diarrhea and severe anemia. Abnormal physical examination findings included left submandibular lymph node enlargement, pale mucous membrane, cataract, and bloody diarrhea. Results of hematologic examination revealed a marked lymphocytosis resulting in leukocytosis and the markedly increased numbers of small, well-differentiated lymphocytes in the peripheral blood. Serum biochemical abnormalities consisted of elevated AST and ALP, hyperphosphatemia, hypoglycemia, and hypoalbuminemia. Radiographic examination showed cardiomegaly and hepatosplenomegaly. Results of urinalysis included bilirubinuria and proteinuria. Based on results of examination described above, chronic lymphocytic leukemia was diagnosed. Chemotherapy was initiated with cyclophosphamide ( $300mg/m^2$ , IV once every 2 weeks), vincristine ( $0.75mg/m^2$ , IV once every 2 weeks, alternating weeks with the cyclophosphamide), and plus prednisolone ( $50mg/m^2$ , PO, SID for a week, then $20mg/m^2$ , PO every other day). The response to chemotherapy was partially present. This study first demonstrates clinicopathological findings and chemotherapeutic response of chronic lymphocytic leukemia in Korea.


  • 주제어

    chronic lymphocytic leukemia .   chemotherapy .   dog.  

  • 참고문헌 (11)

    1. Altman NH, Squire RA. Diagnosis of canine lymphoma. J Am Vet Med Assoc 1970, 157, 1676-1680 
    2. MacEwen EG, Nancy OB, Amiya KP, Audrey AH. Cyclic combination chemotherapy of canine lymphosarcoma. J Am Vet Med Assoc 1981, 178, 1178-1181 
    3. Jerome MG, Pages JP, Guelfi JF. Monoclonal gammopathies in the dog: A retrospective study of 18 cases (1986-1999) and literature review. J Am Anim Hosp Assoc 2002, 38, 135-147 
    4. Hodgkins EM, Zinkl, Madewell BR. Chronic lymphocytic leukemia in the dog. J Am Vet Med Assoc 1980, 177, 704-707 
    5. Arthur I, Hurvitz, Steve CH, Crig AF. Macroglobulinemia with hyperviscosity syndrome in a dog. J Am Vet Med Assoc 1970, 157, 455-460 
    6. Donald LS, Harvey MG, John EU. Chronic lymphocytic leukaemia and its relationship to other lymphoproliferative disorders. Clin Haematol, 1997, 6, 141-157 
    7. Robert EM, Leifer CE, Gordon BR, MacEwen EG, Hurvitz AI. Plasmapheresis and chemotherapy of hyperviscosity syndrome associated with monoclonal gammopathy in the dog. J Am Vet Med Assoc 1983, 183, 215-218 
    8. Robert EM, Leifer CE, MacEwen EG. Acute lymphoblastic leukemia in the dog: A review of 30 cases. J Am Vet Med Assoc 1983, 183, 859-862 
    9. Nelson RW, Couto CG. Leukemias. In: Couto CG (eds.). Small animal internal medicine. 2nd ed. pp. 1134-1142. Mosby, St. louis, 1998 
    10. Connie EL, Robert EM. Chronic lymphocytic leukemia in the dog: 22 cases (1974-1984). J Am Vet Med Assoc 1986, 189, 214-217 
    11. Ettinger SJ, Feldman EC. Hematopoietic tumors. In: David MV (ed.). Textbook of Veterinary Internal Medicine. 5th ed. pp. 514-515, Saunders, Philadelphia, 2000 

 저자의 다른 논문

  • Lee, Ji-Yun (2)

    1. 2003 "잉글리쉬 쉽독에서 발생한 살서제 중독치료 예" Journal of veterinary clinics = 한국임상수의학회지 20 (2): 245~247    
  • Hong, Eun-Sil (1)

  • Kang, Byeong-Teck (31)

  • Park, Chul (26)

  • Park, Hee-Myung (104)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
  • 대한수의학회 : 저널
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기