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Hepatoprotective Constituents of Cudrania tricuspidata

Tian Yu-Hua    (College of Pharmacy and Phytofermentation Research Center, Wonkwang university   ); Kim Hyun-Chul    (College of Pharmacy and Phytofermentation Research Center, Wonkwang university   ); Cui Jiong-Mo    (College of Medicine, Yanbian University   ); Kim Youn-Chul    (College of Pharmacy and Phytofermentation Research Center, Wonkwang university  );
  • 초록

    Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.


  • 주제어

    Cudrania tricuspidata .   Moraceae .   Isoprenylated xanthone .   Hepatoprotective .   Hep G2 cells.  

  • 참고문헌 (12)

    1. Edoute, Y., Karmon, Y., Roguin, A., and Ben-Ami, H., Fatal liver necrosis associated with the use of nitrofurantoin. Isr. Med. Assoc. J., 3, 382-383 (2001) 
    2. Klee, S., Nurnberger, M. C., and Ungemach, F. R., The consequences of nitrofurantoin-induced oxidative stress in isolated rat hepatocytes: evaluation of pathobiochemical alterations. Chem. Biol. Interact., 93, 91-102 (1994) 
    3. Osseni, R. A., Debbasch, C., Christen, M. O., Rat, P., and Warnet, J. M., Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger. Toxicol. In Vitro, 13, 683-688 (1999) 
    4. Song, E. K., Cho, H., Kim, J.S., Kim, N.Y., An, N. H., Kim, J. A., Lee, S. H., and Kim, Y.C., Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med., 67, 876-877 (2001) 
    5. Zou, Y. S., Hou, A. J., Zhu, G. F., Chen, Y. F., Sun, H. D., and Zhao, Q. S., Cytotoxic isoprenylated xanthones from Cudrania tricuspidata. Bioorg. Med. Chem., 12, 1947-1953 (2004) 
    6. Amit, G., Cohen, P., and Ackerman, Z., Nitrofurantoin-induced chronic active hepatitis. Isr. Med. Assoc. J., 4, 184-186 (2002) 
    7. Hano, Y., Matsumoto, Y., Shinohara, K., Sun, J. Y., and Nomura, T., Structures of four isoprenylated xanthones, cudraxanthones L, M, N, and O from Cudrania tricuspidata., 57, 172-175 (1991) 
    8. Watkins, P. B., Zimmerman, H. J., Knapp, M. J., Gracon, S. I., and Lewis, K. W., Hepatotoxic effects of tacrine administration in patients with Alzheimers disease. J. Am. Med. Assoc., 271, 992-998 (1994) 
    9. Grant, M. H., Duthie, S. J., Gray, A. G., and Bruke, M. D., Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line. Biochem. Pharmacol., 37, 4111-4116 (1988) 
    10. Groweiss, A., Cardellina, J. H., and Boyd, M. R., HIV-inhibitory prenylated xanthones and flavones from Maclura tinctoria. J. Nat. Prod., 63, 1537-1539 (2000) 
    11. Jiang su New Medical College. Encyclopedia of Chinese medicinal substances. Shanghai Peoples Publisher, Shanghai, p. 1502 (1977) 
    12. Kelly, B. D., Heneghan, M. A., Bennani, F., Connolly, C. E., and O'Gorman T. A., Nitrofurantoin-induced hepatotoxicity mediated by CD8+ T cells. Am. J. Gastroenterol., 93, 819- 821 (1998) 
  • 이 논문을 인용한 문헌 (5)

    1. 2005. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 28(12): 1324~1327     
    2. Choi, So-Ra ; You, Dong-Hyun ; Kim, Jong-Yeob ; Park, Chun-Bong ; Kim, Dae-Hyang ; Ryu, Jeong ; Choi, Dong-Geun ; Park, Hyun-Mi 2009. "Antimicrobial Activity of Methanol Extracts from Cudrania tricuspidata Bureau according to the Parts Harvested and Time" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 17(5): 335~340     
    3. 2009. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 32(2): 195~200     
    4. 2009. "" Journal of the Korean Society for Applied Biological Chemistry, 52(3): 234~240     
    5. 2010. "" Natural product sciences, 16(2): 75~79     

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