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Immunobioloical Activity of a New Benzyl Benzoate from the Aerial Parts of Solidago virga-aurea var. gigantea

Choi Sang Zin    (Natural Products Laboratory, College of Pharmacy, SungkyunKwan University   ); Choi Sang Un    (Korea Research Institute of Chemical Technology   ); Bae Seong Yun    (Division of Immunophar-macology, College of Pharmacy, SungKyunKwan University   ); Pyo Suhk neung    (Division of Immunophar-macology, College of Pharmacy, SungKyunKwan University   ); Lee Kang Ro    (Natural Products Laboratory, College of Pharmacy, SungkyunKwan University  );
  • 초록

    The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea Mo. (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2-5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxy­benzoate (2), 2-methoxybenzyl-2,6-dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6­hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds, 1 and 2, were investigated in vitro usingherapeutic agents by stimulating macrophage functions, with potential use in the treat­ mouse peritoneal macrophages. The benzylbenzoates (1 and 2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases.


  • 주제어

    Solidago virga-aurea var.   gigantea .   Compositae .   Benzyl benzoates .   Macrophage.  

  • 참고문헌 (13)

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    10. Son, E. W., Cho, C. K., Rhee, D. K., and Pyo, S., Inhibition of gamma-irradiation induced adhesion molecules and NO production by alginate in human endothelial cells. Arch. Pharm. Res., 24(5), 466-471 (2001) 
    11. Moon, E. Y., Rhee, D. K., and Pyo, S., Inhibition of various functions in murine peritoneal macrophages by aflatoxin B1 exposure in vivo. Int. J. Immunopharmacol., 21, 47-58 (1999) 
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    13. Sone, S. and Key, M. E., Antitumor and phagocytic activities of rat alveolar macrophage subpopulations separated on a discontinuous gradient of bovine serum albumin. J. Biol. Resonse. Mod., 5, 595-603 (1986) 
  • 이 논문을 인용한 문헌 (2)

    1. Park, Hee-Juhn ; Nugroho, Agung ; Lee, Jin-Ha ; Kim, Jong-Dae ; Kim, Won-Bae ; Lee, Kang-Ro ; Choi, Jae-Sue 2009. "HPLC Analysis of Caffeoylquinic Acids in the Extract of Cacalia firma and Peroxynitrite Scavenging Effect" 생약학회지, 40(4): 365~369     
    2. 2009. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 32(10): 1361~1367     

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  • Pyo, Suhk-Neung (61)

  • Lee, Kang-Ro (98)

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