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Bone Loss Preventing Effect of Sophorae Fructus On Ovariectomized Rats

Shim Jae Geul    (College of Pharmacy, Chung-Ang University   ); Yeom Seung Hwan    (College of Pharmacy, Chung-Ang University   ); Kim Hyun Jung    (College of Pharmacy, Chung-Ang University   ); Choi Young Wook    (College of Pharmacy, Chung-Ang University   ); Lee Do Ik    (College of Pharmacy, Chung-Ang University   ); Song Kye Yong    (College of Medicine, Chung-Ang University   ); Kwon Suk Hyung    (Rexgene Biotech Co., Ltd.   ); Lee Min Won    (College of Pharmacy, Chung-Ang University  );
  • 초록

    The preventive effects of Sophorae Fructus extracts (I: hot water extract and II: combination product using I) on bone loss in ovariectomized (OVX) rats were investigated. Sophorae Fructus extracts were orally administrated to OVX rats for 9 weeks. Ovariectomy caused the increase of body weight and deoxypyridinoline (Dpd: bone resorption marker) and decrease of calcium (Ca: bone formation marker) level in serum. Dpd level were significantly decreased and Ca levels were elevated at 9 weeks in Sophorae Fructus extracts administered groups after ovariectomy at a dose of 0.556 g/kg/day compared with control group. In administered groups, trabecular bone area (TBA) in the tibia and lumbar were also increased compared with control group in histomorphological analysis. The preventive or treatment effects of Sophorae Fructus extracts on bone loss in OVX rats appears to be due to suppression of bone turnover.


  • 주제어

    Sophorae fructus .   Osteoporosis .   Ovariectomy .   Deoxypyridinoline .   Calcium level .   Trabecular bone area.  

  • 참고문헌 (24)

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  • 이 논문을 인용한 문헌 (3)

    1. 2010. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 33(4): 523~530     
    2. Do, Yoon-Jung ; Ku, Sae-Kwang ; Kim, Hong-Tae ; Oh, Tae-Ho ; Cho, Young-Moo ; Kim, Sung-Woo ; Ryu, Il-Sun ; Lee, Keun-Woo 2011. "Antiosteoporotic Effects of Polygoni Multiflori Radix (PMR) in Ovariectomized (OVX)-Induced Osteoporosis ddY Mice" Journal of veterinary clinics = 한국임상수의학회지, 28(4): 375~386     
    3. Kang, Young-Soon ; Han, Min Ho ; Lee, Moon Hee ; Hong, Su Hyun ; Park, Heungsik ; Jung, Jae-Chul ; Lee, Jeongrai ; Lee, Eun-Woo ; Kang, Kyung Hwa ; Kim, Cheol Min ; Kim, Byung-Woo ; Choi, Yung Hyun 2013. "Fructus Sophorae Enhances the Production of Prostaglandin E2 and Tumor Necrosis Factor-α through Activation of MAPKs and PI3K/AKT Signaling Pathways in Murine Macrophages" 생명과학회지 = Journal of life science, 23(11): 1397~1403     

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