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Antihistamine Effects of Triprolidine from the Transdermal Administration of the TPX Matrix in Rats

Shin Sang-Chul    (College of Pharmacy, Chonnam National University   ); Choi Jun-Shik    (College of Pharmacy, Chosun University  );
  • 초록

    The antihistamine effects of the triprolidine were studied in rats to determine the feasibility of their enhanced transdermal delivery from the poly (4-methyl-1-pentene) (TPX) matrix system containing penetration enhancer and plasticizer. The antihistamine effects were determined by the Evans blue dye procedure by comparing the changes in vascular permeability increase following the transdermal administration. The vascular permeability increase was significantly reduced by transdermal administration of the triprolidine-TPX system containing triethyl citrate (TEC) and polyoxyethylene-2-oleyl ether (POE). Both the plasticizer and penetration enhancer played an important role in the skin permeation of triprolidine and increased the antihistamine effects. These results showed that the triprolidine-TPX matrix system containing plasticizer and penetration enhancer could be a transdermal delivery system providing the increased antihistamine effects.


  • 주제어

    Triprolidine .   TPX .   Antihistamine effects .   Vascular permeability increase .   Evans blue.  

  • 참고문헌 (12)

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    10. Gennaro, A. R., Remington (Eds.). The science and practice of pharmacy. 19th ed., Mack publishing company, Easton, PA, pp. 1207-1218 (1995) 
    11. Katayama, S., Shionoya. H., and Ohtake, S., A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea pigs and rats. Microbiol. Immunol., 22, 89-101 (1978) 
    12. Chien, Y. W., 'Transdermal controlled systemic medications', Marcel Dekker, Inc., New York and Basel, pp. 132-137 (1987) 

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