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Design and Synthesis of Novel Antidiabetic Agents

Lee Joon Yeol    (College of Pharmacy & Research Institute of Drug Development, Chonnam National University   ); Park Won-Hui    (College of Pharmacy & Research Institute of Drug Development, Chonnam National University   ); Cho Min-Kyoung    (College of Pharmacy & Research Institute of Drug Development, Chonnam National University   ); Yun Hyun Jin    (College of Pharmacy & Research Institute of Drug Development, Chonnam National University   ); Chung Byung-Ho    (College of Pharmacy & Research Institute of Drug Development, Chonnam National University   ); Pak Youngmi Kim    (Asan Institute for Life Sciences, Department of Internal Medicine, College of Medicine, University of U1san   ); Hahn Hoh-Gyu    (Life Science Division, Korea Institute of Science and Technology   ); Cheon Seung Hoon    (College of Pharmacy & Research Institute of Drug Development, Chonnam National University  );
  • 초록

    The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma ( $PPAR{\gamma}$ ) are reported. The $PPAR{\gamma}$ agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.


  • 주제어

    Antidiabetic agents .   Quercetin .   Thiazolidinedione .   Malonate.  

  • 참고문헌 (20)

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