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Diastereoselective Synthesis of Polysubstituted Pyrrolidinone as a Key Intermediate for the Anticancer Agents by Palladium(II)­Catalyzed Carboxylation

Choi Dong-Rack    (College of Pharmacy, SungKyunKwan University   ); Lee Kee-Young    (College of Pharmacy, SungKyunKwan University   ); Chung Yun-Sung    (College of Pharmacy, SungKyunKwan University   ); Joo Jae-Eun    (College of Pharmacy, SungKyunKwan University   ); Kim Yong-Hyun    (College of Pharmacy, SungKyunKwan University   ); Oh Chang-Young    (College of Pharmacy, SungKyunKwan University   ); Lee Yiu-Suk    (College of Pharmacy, SungKyunKwan University   ); Ham Won-Hun    (College of Pharmacy, SungKyunKwan University  );
  • 초록

    Palladium(II)-catalyzed carboxylation of chiral olefins 6a-d has been examined under various conditions. In the weak basic condition ( $K_{2}CO_3$ ), 7a-d were obtained in good yields. Alternatively, in the strong basic condition, pyrrolidinones 8a-d were obtained resulting in excellent yields and with high diastereoselectivity.


  • 주제어

    Palladium .   Carboxylation .   Pyrrolidinone .   Stereocontrol.  

  • 참고문헌 (19)

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