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Inhibition of Calmodulin-Dependent Protein Kinase II by Cyclic and Linear Peptide Alkaloids from Zizyphus Species

Han Yong Nam    (Natural Products Research Institute, College of Pharmacy, Seoul National University   ); Hwang Keum Hee    (Korea Bio-Food and Drug Research Center, Konkuk University   ); Han Byung Hoon    (Natural Products Research Institute, Seoul National University  );
  • 초록

    The effects of sedative peptide alkaloids from Zizyphus species on calmodulin- dependent protein kinase II were investigated. Protein kinase II activity was assayed on the basis of its ability to activate tryptophan 5-monooxygenase as its substrate in the presence of calmodulin. All thirteen alkaloids tested were stronger inhibitors than chlorpromazine ( $IC_50,\;98{\mu}M$ ) on calmodulin-dependent protein kinase II. Among them, the most potent inhibitor was daechuine S27 ( $IC_{50},\;2.95{\mu}M$ ), which was stronger than pimozide ( $IC_{50},\;15.0{\mu}M$ ).


  • 주제어

    Zizyphus alkaloids .   Calmodulin-dependent protein kinase II .   Peptide alkaloid .   Calmodulin .   Rhamnaceae.  

  • 참고문헌 (24)

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