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Inhibitory Activity of Isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase

Oh Hyun Mi    (Korea Research Institute of Bioscience and Biotechnology, KIST   ); Kwon Byoung-Mog    (Korea Research Institute of Bioscience and Biotechnology, KIST   ); Baek Nam-In    (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University   ); Kim Sung-Hoon    (Graduate School of East-West Medical Science, KyungHee University   ); Chung In-Sik    (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University   ); Park Mi-Hyun    (Erom Life Co. Ltd.   ); Park Hee Wook    (College of Pharmacy, Woosuk University   ); Lee Jae Hyeok    (College of Pharmacy, Woosuk University   ); Park Hye Won    (College of Pharmacy, Woosuk University   ); Kim Eun Jeong    (College of Pharmacy, Woosuk University   ); Kim Dae Keun    (College of Pharmacy, Woosuk University  );
  • 초록

    The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the $IC_{50}$ value of isorhamnetin was $37.5\;{\mu}M$ .


  • 주제어

    Persicaria thunbergii .   FPTase .   Isorhamnetin.  

  • 참고문헌 (12)

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  • 이 논문을 인용한 문헌 (6)

    1. 2006. "" Natural product sciences, 12(4): 214~216     
    2. 2007. "" Natural product sciences, 13(4): 328~331     
    3. 2007. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 30(3): 299~302     
    4. Lee, Il-Kyun ; Yang, Min-Cheol ; Lee, Kyu-Ha ; Choi, Sang-Un ; Lee, Kang-Ro 2007. "Phenolic Constituents from the Flowers of Synurus excelsus" 생약학회지, 38(2): 181~186     
    5. 2009. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 32(4): 495~499     
    6. Kim, Sang-Bo ; Seong, Yeong-Ae ; Jang, Hee-Jae ; Kim, Gun-Do 2011. "The Anti-Inflammatory Effects of Persicaria thunbergii Extracts on Lipopolysaccharide-Stimulated RAW264.7 Cells" 생명과학회지 = Journal of life science, 21(12): 1689~1697     

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