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Butyrylcholinesterase Inhibitory Guaianolides from Amberboa ramosa

Khan Sher Bahadar    (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi   ); Haq Azhar-ul    (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi   ); Perveen Shagufta    (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi   ); Afza Nighat    (Pharmaceutical Research Centre, PCSIR Labs Complex Karachi   ); Malik Abdul    (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi   ); Nawaz Sarfraz Ahmad    (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi   ); Shah Muhammad Raza    (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi   ); Choudhary Muhammad lqbal    (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi  );
  • 초록

    Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as $8{\alpha}$ -hydroxy- $11{\beta}$ -methyl- $1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\alpha}H-guai-10(14)$ , 4(15)-dien-6, 12-olide(2), $3{\beta},\;8{\alpha}-dihydroxy-11{\alpha}-methyl-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\beta}H-guai-10(14)$ , 4(15)-dien-6, 12-olide (2), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$ , 11(13)-dien-6, 12-olide (3), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}-(chloromethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$ , 11(13)-dien-6, 12-olide(4), $3{\beta},\;4{\alpha},\;dihydroxy-4{\beta}-(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$ , 11(13)-dien-6, 12-olide(5), $3{\beta},\;4{\alpha}-dihydroxy-4{\beta}-(chloromethyl)-8{\alpha}-(4-hydroxymethacrylate)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$ , 11(13)-dien-6, 12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.


  • 주제어

    Amberboa ramosa .   Compositae .   Guaianolides .   Butyrylcholinesterase inhibition.  

  • 참고문헌 (13)

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    12. Schwarz, M., Glick, D., Loewensten, Y., and Soreq, H., Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons. Pharmacol. Ther., 67, 283-322 (1995) 
    13. Meyer, B. N., Ferrigni, N. R., Putnam, J. E., Jacobsen, L. B., Nichols, D. E., and McLaughlin, J. L., Brine shrimp: A convential general bioassay for active plant constituents. Planta Med., 45, 31-34 (1982) 

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