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Anti-Estrogenic Activity of Lignans from Acanthopanax chiisanensis Root

Lee Sanghyun    (College of Pharmacy, Seoul National University   ); Yoo Hye Hyun    (College of Pharmacy, Seoul National University   ); Piao Xiang Lan    (College of Pharmacy, Seoul National University   ); Kim Ju Sun    (Natural Products Research Institute, Seoul National University   ); Kang Sam Sik    (Natural Products Research Institute, Seoul National University   ); Shin Kuk Hyun    (Natural Products Research Institute, Seoul National University  );
  • 초록

    Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3­(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity ( $IC_{50}\;=\;4.86\;{\mu}M$ ).


  • 주제어

    Acanthopanax chiisanensis .   Araliaceae .   Lignan .   Savinin .   Anti-estrogenic activity.  

  • 참고문헌 (16)

    1. Banerji, J., Das, B., Chatterjee, A., and Shoolery, J. N., Gadain, a lignan from Jatropha gossypifolia. Phytochemistry, 23, 2323-2327 (1984) 
    2. Holinka, C. F., Hata, H., Kuramoto, H., and Gurpide, E., Effects of steroid hormones and antisteroids on alkaline phosphatase activity in human endometrial cancer cells (Ishikawa line). Cancer Res., 46, 2771-2774 (1986) 
    3. Lee, S., Shin, K. H., Lee, S. C., and Cho, S. H., Lignans from the root of Acanthopanax chiisanensis Nakai. Kor. J. Med. Crop Sci., 11, 279-283 (2003)     
    4. Meagher, L. P., Beecher, G. R., Flanagan, V. P., and Li, B. W., Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal. J. Agric. Food Chem., 47, 3173-3180 (1999) 
    5. Ososki, A. L. and Kennelly, E. J., Phytoestrogens: a review of the present state of research. Phytother. Res., 17, 845-869 (2003) 
    6. Pisha, E. and Pezzuto, J. M., Cell-based assay for the determination of estrogenic and anti-estrogenic activities. Methods Cell Sci., 19, 37-43 (1997) 
    7. Chang, L. C., Gills, J. J., Bhat, K. P., Luyengi, L., Farnsworth, N. R., Pezzuto, J. M., and Kinghorn, A. D., Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities. Bioorg. Med. Chem. Lett., 10, 2431-2434 (2000) 
    8. Shieh, H. L., Cordell, G. A., Lankin, D. C., and Lotter, H., The liquid, solid and molecular force field calculated conformations of savinin. J. Org. Chem., 55, 5139-5145 (1990) 
    9. Ina, H., Asai, A., Iida, H., and Ushida, T., Chemical investigation of Hydrocotyle sibthorpioides. Planta Med., 53, 228 (1987) 
    10. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63 (1983) 
    11. Yook, C. S., Coloured Medicinal Plants of Korea, Seoul: Academy Book Co., p. 370 (1990) 
    12. Xie, L.-H., Akao, T., Hamasaki, K., Deyama, T., and Hattori, M., Biotransformation of pinoresinol diglucoside to mammalian lignans by human intestinal microflora, and isolation of Enterococcus faecalis strain PDG-1 responsible for the transformation of (+)-pinoresinol to (+)-lariciresinol. Chem. Pharm. Bull., 51, 508-515 (2003) 
    13. Setchell, K. D. R. and Adlercreutz, H., In Role of the Gut Flora in Toxicity and Cancer, ed. by Rowland I. R., Academic Press, San Diego, pp. 315-345 (1988) 
    14. Heinonen, S., Nurmi, T., Liukkonen, K., Poutanen, K., Wahala,K., Deyama, T., Nishibe, S., and Adlercreutz, H., In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. J. Agric. Food Chem., 49, 3178-3186 (2001) 
    15. Stevenson, R. and Weber, J. V., Improved methods synthesis of lignan arylnaphthalene lactones via arylpropargyl arylpropiolat e esters. J. Nat. Prod., 52, 367-375 (1989) 
    16. Perry, L. M., Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses, Cambridge, Massachusetts and London: MIT Press, p. 41 (1980) 
  • 이 논문을 인용한 문헌 (3)

    1. 2006. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 29(9): 741~745     
    2. Shim, Sun-Yup ; Sung, Chan-Ki ; Lee, Sang-Won ; Choi, Young-Ju ; Kim, Hyeung-Rak ; Byun, Dae-Seok 2007. "Inhibitory Effects of Acanthopanax chiisanensis Ethanolic Extracts on FcεRI α Chain Expression" 생명과학회지 = Journal of life science, 17(11): 1511~1516     
    3. 2008. "" Natural product sciences, 14(3): 167~170     

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