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Synthetic Wogonin Derivatives Suppress Lipopolysaccharide-Induced Nitric Oxide Production and Hydrogen Peroxide-Induced Cytotoxicity

Chun Wanjoo    (Department of Pharmacology, Kangwon National University   ); Lee Hee Jae    (Department of Pharmacology, Kangwon National University   ); Kong Pil-Jae    (Department of Pharmacology, Kangwon National University   ); Lee Gun Hee    (Department of Pharmacology, Kangwon National University   ); Cheong Il-Young    (Department of Anesthesiology, College of Medicine, Kangwon National University   ); Park Haeil    (College of Pharmacy, Kangwon National University   ); Kim Sung-Soo    (Department of Pharmacology, Kangwon National University  );
  • 초록

    Wogonin (5,7-dihydroxy-8-methoxyflavone) has been reported to exhibit a variety of biological properties including anti-inflammatory and neuroprotective functions. In this study, biological activities of diverse synthetic wogonin derivatives have been evaluated in two experimental cell culture models. Inhibitory activities of wogonin derivatives on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglial cells and on hydrogen peroxide ( $H_{2}O_2$ )-induced neuronal cell death in SH-SY5Y human neuroblastoma were examined. Wogonin derivatives such as WS2 and WS3 showed more potent suppressive activities on LPS-induced NO production and $H_{2}O_2$ -induced cytotoxicity than wogonin itself. In addition, thiol substitution played a minor role in enhancing the activities of the derivatives. These findings may contribute to the development of novel anti-inflammatory and neuroprotective agents derived from wogonin.


  • 주제어

    Wogonin .   Thiowogonin .   Wogonin derivatives .   Nitric oxide (NO) .   Neuronal death .   BV2 microglia .   SH-SY5Y neuroblastoma.  

  • 참고문헌 (18)

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  • 이 논문을 인용한 문헌 (1)

    1. 2008. "" Journal of microbiology and biotechnology, 18(12): 1990~1996     

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  • Lee, Hee-Jae (25)

  • Kong Pil-Jae (3)

  • Cheong Il-Young (2)

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