본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of ginseng research = 高麗人參學會誌 v.29 no.1 = no.77, 2005년, pp.19 - 26   피인용횟수: 4

Ginseng and ion channels: Are ginsenosides, active component of Panax ginseng, differential modulator of ion channels?

Jeong, Sang-Min    (Research Laboratory for the Study of Ginseng Signal Transduction and Dept. of Physiology, College of Veterinary Medicine, Konkuk University   ); Nah, Seung-Yeol    (Research Laboratory for the Study of Ginseng Signal Transduction and Dept. of Physiology, College of Veterinary Medicine, Konkuk University  );
  • 초록

    The last two decades have shown a marked expansion in publications of diverse effects of Panax ginseng. Ginsenosides, as active ingredients of Panax ginseng, are saponins found in only ginseng. Recently, a line of evidences shows that ginsenosides regulate various types of ion channel activity such as $Ca^{2+},\;K^+,\;Na^+,\;Cl^-$ , or ligand gated ion channels (i.e. $5-HT_3$ , nicotinic acetylcholine, or NMDA receptor) in neuronal, non-neuronal cells, and heterologously expressed cells. Ginsenosides inhibit voltage-dependent $Ca^{2+},\;K^+,\;and\;Na^+$ channels, whereas ginsenosides activate $Ca^{2+}-activated\;Cl^-\;and\;Ca^{2+}-activated\;K^+$ channels. Ginsenosides also inhibit excitatory ligand-gated ion channels such as $5-HT_3$ , nicotinic acetylcholine, and NMDA receptors. This review will introduce recent findings on the ginsenoside-induced differential regulations of ion channel activities and will further expand the possibilities how these ginsenoside-induced ion channel regulations are coupled to biological effects of Panax ginseng.


  • 주제어

    Panax ginseng .   ginsenoside .   ion channel .   ligand-gated ion channel .   differential regulation.  

  • 참고문헌 (40)

    1. Tyler, V. E. : Herbal remedies. J Pharm Technol 11, 214-220 (1995) 
    2. Nah, S. Y. : Ginseng; Recent advances and Trends. J. Ginseng Res. 21, 1-12 (1997) 
    3. Nah, S. Y., Park, H. J. and McCleskey, E.W. : A trace component of ginseng that inhibit $Ca^{2+}$ channels through a pertussis toxin-sensitive G protein. Proc Natl Acad Sci USA 92, 8739-8743 (1995) 
    4. Rhim, H., Kim, H., Lee, D. Y., Oh, T. H. and Nab, S. Y. : Ginseng and ginsenoside $Rg_3$, a newly identified active ingredient of ginseng, modulate $Ca^{2+}$ channel currents in rat sensory neurons. Eur. J. Pharmacol. 436, 151-158 (2002) 
    5. Miller, R. J. : Rocking and rolling with $Ca^{2+}$ channels. Trends in Neurosci. 24, 445-449 (2001) 
    6. Nah, S.Y. and McCleskey, E. W. : Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as m-type opioids. J Ethnopharmacol 42, 45-51 (1994) 
    7. Kim, H. S., Lee, J. H., Koo, Y. S. and Nab, S. Y. : Effects of ginsenosides on $Ca^{2+}$ channels and membrane capacitance in rat adrenal chromaffin cells. Brain Res Bull. 46, 245-251 (1998) 
    8. Choi, S., Jung, S. Y., Kim, C. H., Kim, H. S., Rhim, H., Kim, S. C. and Nah, S. Y. : Effect of ginsenosides on voltagedependent $Ca^{2+}$ channel subtypes in bovine chromaffin cells. J. Ethnopharmacol. 74, 75-81 (2001) 
    9. Wickman, K. D. and Clapham, D. E. : G-protein regulation of ion channels. Current Opinion in Neurobiology 5, 278-285 (1995) 
    10. Chung, I. and Kim, N. D. : Ginseng saponins enhance maxi $Ca^{2+}$ -activated $K^+$ currents of the rabbit coronary artery smooth muscle cells. J. Ginseng Res. 23, 230-234 (1999) 
    11. Chung, I. and Lee, J. S. : Ginsenoside $Rg_3$ increases the ATPsensitive $K^+$ channel activity in the smooth muscle of the rabbit coronary artery. J. Ginseng Res. 23, 235-238 (1999) 
    12. Li, Z., Chen, X., Niwa, Y., Sakamoto, S. and Nakaya, Y. : Involvement of $Ca^{2+}$-activated $K^+$ channels in ginsenosidesinduced aortic relaxation in rats. J.Cardiovasc. Pharmacol. 37,41-47 (2001) 
    13. Jeong, S. M., Lee, J. H., Kim, J. H., Lee, B. H., Yoon, I. S., Lee, J. H., Kim, D. H., Rhim, H., Kim, Y. and Nah, S. Y. : Stereospecificity of ginsenoside $Rg_3$ action on ion channels. Mol. Cells 18, 383-389 (2004) 
    14. Liu, D., Li., B., Liu, Y, Attele, A.S., Kyle, J. W. and Yuan, C. S. : Voltage-dependent inhibition of brain $Na^+$ channels by American ginseng. Eur. J. Pharmacol. 413, 47-54 (2001) 
    15. Lindstrom, J. : Nicotinic acetylcholine receptors. p153-175. In: North, A (ed), CRC Handbook of Receptors. CRC Press, Florida (1995) 
    16. Sargent, P. B. : The diversity of neuronal nicotinic acetylcholine receptor. Ann. Rev. Neurosci. 16,403-443 (1993) 
    17. Tachikawa, E., Kudo, T., Kashimoto, T. and Takashshi, E. : Ginseng saponins reduce acetylcholine-evoked $Na^+$ influx and catecholamine secretion in bovine adrenal chromaffin cells. J Pharmacol Exp Ther. 273, 629-636 (1995) 
    18. Campos-Caro, A., Smillie, E. I., Del Toro, E. D., Rovira, J. C., Vicente-Agullo, E., Chapuli, J., Juiz, J. M., Sala, S., Sala, E., Ballesta, J. and Criado, M.: Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells: cloning, expression, and genomic organization of receptor subunits. J. Neurochem. 68,488-497 (1997) 
    19. Choi, S., Jung, S. Y, Lee, J. H., Sala, E., Criado, M., Mulet, J., Valor L. M., Sala, S., Engel, A. G. and Nah, S. Y.: Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 442, 37-45 (2002) 
    20. Sala, F., Mulet, J., Choi, S., Jung, S. Y., Nah, S. Y., Rhim, H., Valor, L. M., Criado, M. and Sala, S. : Effects of ginsenoside $Rg_2$ on human neurona nicotinic acetylcholine receptors. J. Pharm. Exp. Ther. 301, 1052-1059 (2002) 
    21. Choi, S., Lee, J. H., Oh, S., Rhim, H., Lee, S. M. and Nah, S. Y. : Effects of ginsenoside $Rg_2$ on the 5-$HT_3$ receptor-mediated ion current in Xenopus oocytes. Mol. Cells 15, 108-113 (2003) 
    22. Lee, B. H., Jeong, S. M., Lee, J. H., Kim, D. H., Kim, J. H., Kim, J. I., Shin, H. C, Lee, S. M. and Nah, S. Y : Differential effect of ginsenoside metabolites on the 5-$HT_{3A}$ receptor-mediated ion current in Xenopus oocytes. Mol. Cells 17, 51-56 (2004) 
    23. Dingledine, R., Borges, K., Bowie, D. and Traynelis, S. E : Glutamate receptor ion channels. Pharmacol. Rev. 51, 7-62 (1999) 
    24. Kim, Y. C, Kim, S. R., Markelonis, G. J. and Oh, T. H. : Ginsenosides $Rb_1$and $Rg_3$ protect cultured rat cortical cells from glutamate-induced neurodegeranation. J. Neurosci. Res.53.426-432 (1998) 
    25. Seong, Y. H., Shin, C S., Kim, H. S. and Baba, A. : Inhibitory effect of ginseng total saponins on glutamate-induced swelling of cultured atrocytes. Biol. Pharm.Bull. 18, 1776-1778 (1995) 
    26. Abe, K., Cho, S. I., Kitagawa, I., Nishiyama, N. and Saito, H. : Differential effects of ginsenoside $Rb_1$ and malonylginsenoside $Rb_1$ on long-term potentiation in the dentate gyrus of rats. Brain Res. 649, 7-11 (1994) 
    27. Yoon, S. R., Nah, J. J., Shin, Y. H., Kim, S. K., Nam, K. Y., Choi, H. S. and Nah, S. Y. : Ginsenosides induce differential antinocicepion and inhibit substance P induced-nociceptive response in mice. Life Sci. 62, PL319-PL325 (1998) 
    28. Nah, J. J., Choi, S., Kim, Y. H., Kim, S. C, Nam, K. Y., Kim, J. K. and Nah, S. Y. : Effect of spinally administered ginseng total saponin on capsaicin-induced pain and excitatory amino acid-induced nociceptive responses. J. Ginseng Res. 23, 38-43 (1999) 
    29. Kim, S., Ahn, K., Oh, T. H., Nah, S. Y. and Rhim, H. : Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun. 296, 247-254 (2002) 
    30. Hong, H.Y., Yoo, G. S. and Choi, J. K. : Effects of ginsenosides on pp60c- sre kinase, intracellular calcium and cell proliferation in NIH 3T3 cells. J Ginseng Res 22, 126-132 (1998) 
    31. Choi, S., Rho, S. H., Jung, S. Y., Kim, S. C., Park, C. S. and Nah, S. Y. : A novel activation of $Ca^{2+}$-activated $CI^-$ channel in Xenopus oocytes by ginseng saponins: evidence for the involvement of phospholipase C and intracellular $Ca^{2+}$ mobilization. British J. Pharmacol. 132, 641-648 (2001) 
    32. Jeong, S. M., Lee, J. H., Kim, S., Rhim, H., Lee, R.H., Kim, J. H., Oh, J. W., Lee, S. M. and Nah, S. Y. : Ginseng saponins induce store-operated calcium entry in Xenopus oocytes. Br. J. Pharmacol. 142, 585-593 (2004) 
    33. Berridge, M. J., Bootman, M. D. and Lipp, P. : Calcium - a life and death signal. Nature, 395, 645-668 (1998) 
    34. Choi, S., Jung, S. Y., Ko, Y. S., Koh, S. R., Rhim, H. and Nah, S. Y. : Functional Expression of a novel ginsenoside Rf binding protein from rat brain mRNA in Xenopus oocytes. Mol. Pharmacol. 61, 928-935 (2002) 
    35. Shin, E. K., Park, H. W., Kim, S. C. and Jung, N. P. : The effect of ginseng components on the signal transduction in the activation of murine macrophages. Kor J Ginseng Sci 20, 159-167 (1996) 
    36. Choi, S., Kim, H. J., Ko, Y. S., Jeong, S. W., Kim, Y. I., Simonds, W. E, Oh, j. W. and Nab, S. Y. :$G{\alpha}_{q/11}$ coupled to mammalian PLC$\beta$3-like enzyme mediates the ginsenoside effect on $Ca^{2+}$ -activated CJ current in the Xenopus oocyte. J. Biol. Chem. 276, 48797-48802 (2001) 
    37. Kim, N. K., Kang, S. Y., Park, J. H. and Schini-Kerth, V. B. : Ginsenoside $Rg_3$ mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: role of $K^+$ channels. Eur. J. Pharmacol. 367, 41-49 (1999) 
    38. Dascal, N. : Signaling via the G prorein-activated $K^+$ channels. Cell Signal. 9,551-573 (1997) 
    39. Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M. and Julius, D. : Primary structure and functional expression of the 5-$HT_3$ receptor, a serotonin-gated ion channel. Science, 254, 432-437 (1991) 
    40. Lee, J. H., Kim, S. H., Kim, D., Hong, H. N. and Nah, S. Y. : Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainate-induced neurotoxicity in rat hippocam- pus. Neurosci. Lett. 325, 129-133 (2001) 
  • 이 논문을 인용한 문헌 (4)

    1. 2006. "" Journal of ginseng research = 高麗人參學會誌, 30(2): 57~63     
    2. 2009. "" Journal of ginseng research = 高麗人參學會誌, 33(4): 294~304     
    3. 2010. "" Journal of ginseng research = 高麗人參學會誌, 34(3): 246~253     
    4. 2014. "" Journal of ginseng research = 高麗人參學會誌, 38(1): 1~7     

 저자의 다른 논문

  • Jeong, Sang-Min (12)

    1. 2003 "Differential Effect of Bovine Serum Albumin on Ginsenoside Metabolite-Induced Inhibition of ${\alpha}3{\beta}4$ Nicotinic Acetylcholine Receptor Expressed in Xenopus Oocytes" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 26 (10): 868~873    
    2. 2005 "Effects of Korean Red Ginseng Extract on Cisplatin-Induced Nausea and Vomiting" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 28 (6): 680~684    
    3. 2005 "단일 도파민뉴런을 이용한 새로운 유전자발현 검출기법" 한국생물공학회지 = Korean journal of biotechnology and bioengineering 20 (4): 323~327    
    4. 2005 "Xenopus laevis oocytes에서 진세노사이드에 의하여 활성화되는 Ca2+-activated Cl- 이온 통로의 유전자 클로닝, 조직 분포 및 채널 특성" Journal of ginseng research = 高麗人參學會誌 29 (4): 167~175    
    5. 2005 "Effect of Calmodulin on Ginseng Saponin-Induced $Ca^{2+}$-Activated $Cl^{-}$ Channel Activation in Xenopus laevis Oocytes" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 28 (4): 413~420    
    6. 2005 "The Inhibitory Effects of Korean Red Ginseng Saponins on 5- HT3A Receptor Channel Activity Are Coupled to Anti-Nausea and Anti-Vomiting Action" Journal of ginseng research = 高麗人參學會誌 29 (1): 37~43    
    7. 2006 "Transcriptional Features of the Chromosomal Region Located between the sigH and rplA Genes of Bacillus subtilis" Biotechnology and bioprocess engineering 11 (2): 168~172    
    8. 2006 "Anti-HIV agent VP-0501의 생체이용성 향상을 위한 아미노산 프로드럭 개발 및 약물동태연구" 大韓獸醫學會誌 = Korean journal of veterinary research 46 (1): 7~12    
  • Nah, Seung-Yeol (29)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기