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생명과학회지 = Journal of life science v.16 no.5 = no.78, 2006년, pp.767 - 772   피인용횟수: 2

Streptozotocin-유발 당뇨쥐의 베타인 첨가에 의한 항당뇨 및 간보호 효과
Hypoglycemic and Hepatoprotective Effects of Betaine on Streptozotocin-Induced Diabetic Rats

정재준    (대선주조주식회사 연구소   ); 김용택    (대선주조주식회사 연구소   ); 서원석    (대선주조주식회사 연구소   ); 양현주    (대선주조주식회사 연구소   ); 이용수    (대선주조주식회사 연구소   ); 차재영    (대선주조주식회사 연구소  );
  • 초록

    Sprague-Dawley 수컷에 streptozotocin (50 mg/kg body weight)을 복강 주사하여 유발시킨 당뇨군에서 베타인(1%, w/w) 첨가에 의한 항당뇨 및 간보호 효과를 검토하였다. Streptozotocin-유발 당뇨군에서 혈당치 및 fructosamine 농도가 현저히 증가하였고, 이러한 증가는 베타인 투여로 감소하였다. 간 기능의 biomarker로 사용되는 alanine aminotransferase (AST) 및 aspartate aminotransferase (ALT) 활성은 당뇨군에서 현저히 증가한 반면 간보호 효과가 있는 베타인 투여 당뇨군에서는 정상군 수준으로 회복됨으로써 당뇨성 간 손상에 효과가 있는 것으로 나타났다. 혈중 중성지질 농도는 당뇨군에서 현저히 증가하였으나, 베타인 투여에 의해 정상군 수준까지 감소하였으나, 총 콜레스테롤 농도는 베타인 첨가에 의해 증가하였다. 췌장 조직의 조직검사에서 췌도 세포의 정상적인 타원형 모양이 정상군에서는 잘 유지되었으나, Streptozotocin-유발 당뇨군에서는 췌도 세포의 파괴가 일어났으며, 베타인 투여에 의해서는 회복된 것으로 나타났다. 이상의 결과로 볼 때 당뇨군에서 베타인 투여에 의한 혈당강하 효과는 췌장의 췌도세포 파괴 억제에 의한 것으로 시사되었다.


    This study was to investigate the effect of betaine on the hypoglycemia and hepatoprotection of streptozotocin(STZ)-induced diabetic rats. Male Sprague-Dawley rats weighing around 280 g were randomly assigned to the three experimental groups: a healthy normal group and two groups with STZ-induced diabetes and fed either control diet or betaine diet. Betaine given to the STZ-diabetic rats had significant effect in lowering the serum glucose concentrations compared to the STZ-diabetic rats. The alanine aminotransferase (AST) and aspartate aminotransferase (ALT) activities and triglyceride contents in serum were dramatically higher in the STZ-diabetic rats, but these increases in relation to diabetes also decreased in the STZ-diabetic rats fed betaine. However, the total-cholesterol concentration in the STZ-diabetic rats was even increased by betaine. The morphology of the pancreatic islets in the normal rats showed a typical round form, but most of the islets in the STZ-diabetic rats showed severe morphological alterations by being markedly destroyed. However, the islet morphology of STZ-diabetic rats given betaine mostly maintained a normal rounded appearance. The present study strongly suggests that the administration of betaine showed a moderate hypoglycemic effect by protecting the pancreatic beta-cells by morphological examination from STZ-induced destruction.


  • 주제어

    Betaine .   streptozotocin .   diabetes mellitus .   hypoglycemia .   hepatoprotection.  

  • 참고문헌 (30)

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  • 이 논문을 인용한 문헌 (2)

    1. Kim, Jung-Wook ; Cha, Jae-Young ; Heo, Jin-Sun ; Jin, Hyun-Jin ; Cho, Young-Su 2008. "Hypoglycemic Effect of Chlorella sp. CMS-1 Hot Water Extract on Streptozotocin-Induced Diabetic Rats" 생명과학회지 = Journal of life science, 18(11): 1584~1591     
    2. Son, Hee-Kyoung ; Lee, Yu-Mi ; Park, Yong-Hyun ; Lee, Jae-Joon 2016. "Effect of Young Barley Leaf Powder on Glucose Control in the Diabetic Rats" 한국지역사회생활과학회지 = The Korean Journal of Community Living Science, 27(1): 19~29     

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