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Journal of bacteriology and virology : JBV v.36 no.4, 2006년, pp.287 - 292   피인용횟수: 1
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한국형 HIV-1 백신 개발을 위한 HIV-1 nef와 vif 유전자의 컨센서스서열과 조상서열의 비교
Comparison of Consensus Sequences and Ancestor Sequences of HIV-1 nef and vif Genes for Development of Korean-Specific HIV-1 Vaccine

박찬승    (충북대학교 자연과학대학 생명과학부   ); 김미숙    (충북대학교 자연과학대학 생명과학부   ); 이현아    (충북대학교 자연과학대학 생명과학부   ); 이건명    (충북대학교 자연과학대학 전기전자컴퓨터공학부   ); 김성수    (충북대학교 자연과학대학 전기전자컴퓨터공학부   ); 이성덕    (충북대학교 자연과학대학 정보통계학과   ); 이찬희    (충북대학교 자연과학대학 생명과학부  );
  • 초록

    There have been attempts to use consensus sequences or ancestor sequences for development vaccines against viruses with high diversity and variation. In this study, we generated and compared consensus sequences and ancestor sequences of nef and vif genes of HIV-1 isolated from Koreans. Phylogenetic analyses revealed that majorities of the Korean isolates were clustered to form the Korean clade within subtype B (KcB) where foreign isolates were not included. Consensus sequences inferred from the KcB as well as from all Korean isolates were almost identical but significantly different from subtype B consensus sequence or HIV-1 consensus sequence. The genetic distances from one of the Korean isolates to the other Korean isolates were much longer than to the consensus or ancestor sequences deduced from Korean isolates but similar to those of subtype B or HIV-1. Moreover, the genetic distances from the Korean isolates to the consensus sequences were shorter than to the ancestor sequences both in nef and vif genes. Thus, the consensus sequences may be useful in developing Korean-specific HIV-1 vaccine.


  • 주제어

    HIV-1 .   Vaccine .   Consensus sequence .   Ancestor sequence.  

  • 참고문헌 (18)

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  • 이 논문을 인용한 문헌 (1)

    1. 2008. "" The journal of microbiology, 46(1): 88~94     

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