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Food science and biotechnology v.15 no.5 = no.71, 2006년, pp.694 - 697   피인용횟수: 1

Suppressive Effects of Scutellaria radix Water Extract on $Fc{\varepsilon}RI$ Expression

Shim, Sun-Yup   (Oriental Medicine Research and Development Institute, Pukyong National UniversityUU0000598  ); Byun, Dae-Seok   (Major of Nutrition, Pukyong National UniversityUU0000598  ); Kim, Hyeung-Rak   (Major of Nutrition, Pukyong National UniversityUU0000598  ); Lee, Kyung-Dong   (Department of Oriental Medicine Materials, Dongshin UniversityUU0000476  ); Cho, Young-Sook   (Department of Food and Nutrition, Sunchon National UniversityUU0000840  );
  • 초록

    The initiation of immunoglobulin E (IgE)-mediated allergic reactions requires binding of IgE antibody to its high-affinity receptor. Human basophilic KU812F cells express $Fc{\varepsilon}RI$ on the cell surface and act as effector cells in the allergic response. In this study, we investigated the effects of Scutellaria radix extract on the expression of the $Fc{\varepsilon}RI$ in human KU812F cells. Flow cytometric analysis showed that S. radix extract treatment caused a concentration-dependent decrease in $Fc{\varepsilon}RI$ expression on the cell surface. Furthermore, the level of $Fc{\varepsilon}RI$ ${\alpha}$ , ${\beta}$ , and ${\gamma}$ chain mRNA in KU812F cells was examined by RT-PCR. S. radix extract reduced total cellular $Fc{\varepsilon}RI$ $\alpha$ and ${\gamma}$ chain mRNA expression in a concentration-dependent manner. $Fc{\varepsilon}RI$ -mediated histamine release was reduced from $21.75{\pm}1.34\;ng/10^6$ cells in non-treated cells to $16.46{\pm}1.98\;ng/10^6$ cells in S. radix extract treated cells. These results suggested that S. radix extract has the potential to down-regulate of FcRI expression and to inactivate basophils.


  • 주제어

    Scutellaria radix .   IgE .   $Fc{\varepsilon}RI$ .   histamine.  

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  • 이 논문을 인용한 문헌 (1)

    1. 2016. "" Preventive nutrition and food science, 21(4): 323~329     

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