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Food science and biotechnology v.15 no.5 = no.71, 2006년, pp.792 - 798   피인용횟수: 8

Characterization of Lactobacillus cellobiosus D37 Isolated from Soybean Paste as a Probiotic with Anti-Cancer and Antimicrobial Properties

Lim, Sung-Mee   (Department of Food Science and Technology, Tongmyong UniversityUU0000460  ); Lee, Goon-Ja   (Department of Food Science and Technology, Tongmyong UniversityUU0000460  ); Park, Sun-Mee   (Epidemiology Division, Busan Metropolitan City Institute of Health and EnvironmentCC0138905  ); Ahn, Dong-Hyun   (Department of Food Science and Technology, Pukyong National UniversityUU0000598  ); Im, Dong-Soon   (College of Pharmacy and Research Institute for Drug Development, Pusan National UniversityUU0000613  );
  • 초록

    The probiotic characteristics of a total of 137 lactic acid bacterial strains isolated from soybean paste were investigated. Among those tested, the D37 strain was selected as a probiotic bacteria due to its acid and bile tolerance, and its strong anti-cancer and antibacterial activities. The D37 strain showed highly stable viability at acidic pH for 2 hr, and was very stable in 10% bovine bile. The viability of human colon cancer HT-29 cells was inhibited more than 60% at a $200\;{\mu}/mL$ concentration of D37 cell-free culture supernatant, and the degree of inhibition was concentration-dependent. The D37 strain showed a wide range of antibacterial activities against food-borne pathogenic bacteria such as Escherichia coli O157, Listeria spp., Vibrio spp., Salmonella spp., and Staphylococcus aureus. According to phenotypic characteristics and the utilization of various sugars, the D37 strain was identified as Lactobacillus cellobiosus.


  • 주제어

    soybean paste .   acid and bile tolerance .   anti-cancer activity .   antimicrobial activity .   Lactobacillus cellobiosus.  

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    8. Lim, Sung-Mee 2014. "Heterocyclic Amines Removal by Binding Ability of Lactic Acid Bacteria Isolated from Soybean Paste" Korean journal of microbiology = 미생물학회지, 50(1): 73~83     

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