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Food science and biotechnology v.15 no.6 = no.72, 2006년, pp.937 - 941  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Absorption Behavior in the Body of Chitosan Oligosaccharide according to Molecular Weight; An In vitro and In vivo Study

Jang, Mi-Kyeong   (Department of Polymer Science and Engineering, Sunchon National UniversityUU0000840  ); Kang, Seong-Koo   (Research Instrument Center, Sunchon National UniversityUU0000840  ); Nah, Jae-Woon   (Department of Polymer Science and Engineering, Sunchon National UniversityUU0000840  );
  • 초록

    Chitosan has a wide range of applications in biomedical materials as well as in dietary supplements. Chitosan oligosaccharide with free-amine group (COFa) is an improvement over traditional chitosan that lacks the usual impurities and materials detrimental to the body. Based on a previous study of water soluble chitosan (WSC, chitosan lactate), we investigated the molecular weight (Mw) - dependent absorption phenomena of COFa in vitro and in vivo with various Mws. The absorption of CO Fa was significantly influenced by its molecular weight. As Mw increases, the absorption decreases. The absorption profiles for 5 K COFa (Mw=5 kDa) were observed to be more than 10 times higher than those of high molecular weight chitosan (100 K HWSC Mw=100 kDa) in both in vitro and in vivo transport experiments. Furthermore, the in vitro transport experiment suggested that transcellular transport of the COFa (Mw


  • 주제어

    COFa .   oral absorption .   TEER value .   molecular weight .   Caco-2 cell.  

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