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신개발 인산칼슘계 근관 봉함재의 세포독성 및 유전독성에 관한 연구
Cytotoxicity and Genotoxicity of Newly Developed Calcium Phosphate-based Root Canal Sealers

김희정    (서울대학교 치과대학 치과보존학교실   ); 백승호    (서울대학교 치과대학 치과보존학교실   ); 배광식    (서울대학교 치과대학 치과보존학교실  );
  • 초록

    본 연구의 목적은 기존 상용화된 근관 봉함재인 레진계 봉함재 (AH 26, AH Plus), 산화 아연 유지놀계 봉함재(Tubliseal EWT Pulp Canal Sealer EWT), 수산화 칼슘계 봉함재 (Sealapex), 기존의 인산삼칼슘계 봉함재(Sankin Apatite type I, II, III)와 새로이 개발된 인산칼슘계 근관 봉함재 (CAPSEAL I, CAPSEAL II)의 세포독성과 유전독성을 비교 평가하고자 하였다. MTT test를 통해 세포독성을 평가하였으며 미생물을 이용한 복귀돌연변이 시험 (Ames test)으로 유전독성을 평가하였다. 이 연구의 결과는 아래와 같다. 1. 즉시군이 24시간군에 비해 MTT assay에서 세포독성이 높게 나타났다 (p


    The purpose of this study was to compare the cytotoxicity by MTT test and genotoxicity by Ames test of new calcium phosphate-based root canal sealers (CAPSEAL I, CAPSEAL II) with commercially available resin-based sealers (AH 26, AH Plus) , zinc oxide eugenol-based sealers (Tubliseal EWT, Pulp Canal Sealer EWT), calcium hydroxide-based sealer (Sealapex), and tricalcium phosphate based sealers (Sankin Apatite Root Canal Sealer I, II, III). According to this study, the results were as follows : 1. The extracts of freshly mixed group showed higher toxicity than those of 24 h set group in MTT assay (p


  • 주제어

    근관 봉함재 .   세포독성 .   유전독성 .   생체적합성 .   인산칼슘.  

  • 참고문헌 (46)

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  • 이 논문을 인용한 문헌 (3)

    1. Kang, Min-Kyung ; Bae, In-Ho ; Koh, Jeong-Tae ; Hwang, Yun-Chan ; Hwang, In-Nam ; Oh, Won-Mann 2009. "COMPARISON OF BIOCOMPATIBILITY OF FOUR ROOT PERFORATION REPAIR MATERIALS" 大韓齒科保存學會誌 = Journal of Korean Academy of Operative Dentistry, 34(3): 192~198     
    2. 2013. "" RDE : Restorative dentistry & endodontics, 38(4): 204~209     
    3. 2014. "" RDE : Restorative dentistry & endodontics, 39(3): 149~154     

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