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Macromolecular research v.14 no.4, 2006년, pp.443 - 448  

Adsorption of Nucleotides on ${\beta}$-Cyclodextrin Derivative Grafted Chitosan

Xiao Jian-Bo    (College of Chemistry and Chemical Engineering, Central South University   ); Yu Hong-Zhu    (College of Chemistry and Chemical Engineering, Central South University   ); Xu Ming    (Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center   ); Chen Xiao-Qing    (College of Chemistry and Chemical Engineering, Central South University  );
  • 초록

    A novel ${\beta}$ -cyclodextrin derivative (CCD-C) was synthesized with chitosan and carboxymethyl- ${\beta}$ -cyclodextrin. Its structure was characterized by elemental analysis, infrared spectra analysis, and X-ray diffraction analysis. The adsorption properties for guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate were studied. Experimental results demonstrated that CCD-C had higher adsorption capability for guanosine 5'-monophosphate, and that the adsorption capacity for guanosine 5'-monophosphate was 74.20mg/g. The adsorption capacity was greatly influenced by pH, time and temperature. The introduction of chitosan enhanced the adsorption ability and adsorption selectivity of ${\beta}$ -cyclodextrin for guanosine 5'-monophosphate. This novel derivative of chitosan is expected to have wide applications in the separation, concentration and analysis of nucleotides in biological samples.


  • 주제어

    chitosan .   carboxymethyl- ${\beta}$-cyclodextrin .   nucleotides .   adsorption.  

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