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The Expression and the Subcellular Localization of Regulatory Subunits of Class IA Phosphoinositide 3-Kinase in L6 Skeletal Muscle Cell

Woo Joo-Hong    (Department of Biological Science, College of Natural Sciences, Ajou University   ); Lim Jeong-Soon    (Department of Biological Science, College of Natural Sciences, Ajou University   ); Kim Hye-Sun    (Department of Biological Science, College of Natural Sciences, Ajou University  );
  • 초록

    PI3-kinase activity through p85, the regulatory subunit of class IA PI3-kinase, is indispensable for the growth, differentiation, and survival of skeletal muscle cells, but little is known about the function of other regulatory subunits such as p55 and p50. We examined the subcellular localization and the expression of the regulatory subunits of class IA PI3-kinase in L6 myoblasts. Both p55 and p50 as well as p85 were expressed in L6 myoblasts. Whereas p85 was localized at both cytosolic and nuclear tractions, p55 and p50 were localized at only the nuclear traction. During the differentiation of L6 myoblasts, the protein concentrations of both p55 and p50 were decreased but that of p85 was not significantly changed. Menadione-induced oxidative stress induced the translocation of p85 from cytosol to nucleus and the increase of p55 expression. These results suggest that the regulatory subunits of class IA PI3-kinase play an important role in L6 myoblasts.


  • 주제어

    PI3-kinase .   L6 myoblasts .   Skeletal muscle differentiation .   Menadione .   Oxidative stress.  

 저자의 다른 논문

  • 우주홍 (4)

    1. 2004 "Developmental Regulation of the Peptide Hydrolyzing Activities of the Proteasome in Myogenic Differentiation" Journal of experimental & biomedical sciences = 대한의생명과학회지 10 (3): 179~186    
    2. 2008 "Identification of to Hexapeptides that Render C2 Myoblasts the Resistant Menadione-induced Cell Death" Animal cells and systems 12 (1): 35~39    
    3. 2010 "Phosphoinositide 3-kinase regulates myogenin expression at both the transcriptional and post-transcriptional level during myogenesis" Animal cells and systems 14 (3): 147~154    
  • Kim, Hye-Sun (7)

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