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Oriental pharmacy and experimental medicine : OPEM v.6 no.4, 2006년, pp.355 - 360   피인용횟수: 2
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Antioxidant, antinociceptive activity and general toxicity study of Dendrophthoe falcata and isolation of quercitrin as the major component

Hasan, Md Shihab    (Pharmacy Discipline, Life Science School, Khulna University   ); Ahmed, Md Iqbal    (Pharmacy Discipline, Life Science School, Khulna University   ); Mondal, Sukla    (Pharmacy Discipline, Life Science School, Khulna University   ); Masud, Mohammad Methedi    (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Unversity of Dhaka   ); Sadhu, Samir Kumar    (Pharmacy Discipline, Life Science School, Khulna University, Graduate School of Pharmaceutical Sciences, Chiba University   ); Ishibashi, Masami    (Graduate School of Pharmaceutical Sciences, Chiba University   ); Uddin, Shaikh Jamal    (Pharmacy Discipline, Life Science School, Khulna University  );
  • 초록

    Plants have been used in traditional medicinal system for centuries. Bangladeshi medicinal plants have received considerable attention from the researchers for evaluation of their bioactivity. As a part of our ongoing research of screening the Bangladeshi medicinal plants, the ethanolic extract of Dendrophthoe falcata have been chosen for the present study. The ethanolic extract of the leaves of the plant have been assessed for their antioxidant, antinociceptive, and general toxicity. The extract showed potent antioxidant activity ( $IC_{50}5.1{\mu}g/ml$ ) using DPPH radical scavenging assay, which is comparable to the standard ascorbic acid ( $IC_{50}4.6{\mu}g/ml$ ). The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (71.2%, P $LC_{50}100{\mu}g/ml$ ). Using different chromatographic techniques, quercitrin (quercetin 3-O- ${\alpha}$ -rhamnoside) was separated as the major component from the extract. The structure was elucidated by detailed 1D and 2D NMR and mass spectral analysis.


  • 주제어

    Dendrophthoe falcata .   Loranthaceae .   Antioxidant .   DPPH .   Antinociceptive .   Toxicity .   Brine shrimp .   Quercetrin.  

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  • 이 논문을 인용한 문헌 (2)

    1. 2009. "" Oriental pharmacy and experimental medicine : OPEM, 9(4): 277~284     
    2. Kim, Jung-Ae ; Karadeniz, Fatih ; Ahn, Byul-Nim ; Kwon, Myeong Sook ; Mun, Ok-Ju ; Kim, Mihyang ; Lee, Sang-Hyeon ; Yu, Ki Hwan ; Kim, Yuck Yong ; Kong, Chang-Suk 2014. "Sargassum sp. Attenuates Oxidative Stress and Suppresses Lipid Accumulation in vitro" 생명과학회지 = Journal of life science, 24(3): 274~283     

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