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약학회지 = Yakhak hoeji v.51 no.5, 2007년, pp.343 - 349  

바위취 에탄올 추출물의 항산화 및 항노화 작용
Anti-oxidant and Anti-aging Activity on Saxifraga stolonifera MEERBURGH Ethanol Extract

윤미연   (건국대학교 미생물공학과UU0000050  ); 임혜원   (이화여자대학교 생명과학과UU0001056  ); 심상수   (중앙대학교 약학대학UU0001197  ); 최태부   (건국대학교 미생물공학과UU0000050  );
  • 초록

    To investigate the effect of ethanol extract of Saxifraga stolonifera MEERBURGH on skin care, we measured anti-oxidant and anti-aging activity. S. stolonifera ethanol extract itself had anti-oxidant activity in a dose-dependent manner in DPPH radical scavenging. Silica dose-dependently increased the intracellular ROS generation in RAW 264.7 cells. S. stolonifera ethanol extract inhibited silica-induced intracellular superoxide anion generation, $H_2O_2$ and hydroperoxide generation in RAW 264.7 cells. S. stolonifera ethanol extract significantly inhibited both hyaluronidase and elastase activity, also significantly inhibited MMP-1(collagenase) activity as well. In NIH 3T3 fibroblast cells, S. stolonifera ethanol extract significantly increased collagen-like polymer synthesis, which suggesting the S. stolonifera ethanol extract might be used as hydration and anti-wrinkle agents. From the above results, it is suggested that the main ingredients of S. stolonifera ethanol extract play an important role in anti-oxidant and anti-aging activity.


  • 주제어

    Saxifraga stolonifera .   ROS .   collagen .   anti-aging.  

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