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약학회지 = Yakhak hoeji v.51 no.5, 2007년, pp.350 - 354   피인용횟수: 1

B16F10 Murine Melanoma 세포에서 멜라닌생성억제에 대한 타우린의 효과
Antimelanogenic Effect of Taurine in Murine Melanoma B16F10 Cells

정효숙   (숙명여자대학교 약학대학UU0000824  ); 송경희   (숙명여자대학교 약학대학UU0000824  ); 김안근   (숙명여자대학교 약학대학UU0000824  );
  • 초록

    Taurine has been shown to be tissue-protective against oxidant-induced injury and is a powerful regulator of the immune system. However, there is no study on the antimelanogenic effect of taurine. In this study, we investigated the whitening effect of taurine in B16F10 mouse melanoma cells. Cell viability was measured by MTT assay. We examined melanin contents and tyrosinase activity according to time and concentration. Extracellular signal regulated kinase (ERK) is an important regulator of melanogenesis. It has been reported that activated ERK induced microphthalmia associated transcription factor (MITF) phosphorylation and its subsequent degradation and thus reduced melanin synthesis. In our B16F10 cell culture system, taurine led to decrease melanin contents by 21% at 48 hr. We then observed taurine effects on ERK-P, MITF and tyrosinase by Western blot. ERK was activated at 18 hr and 24 hr, whereas MITF reduced. We could not observe any differences in the levels of tyrosinase. These results suggested that taurine inhibited melanogenesis by ERK signal pathway via MITF degradation. We expect that taurine has potential skin whitening agents in cosmetics.


  • 주제어

    taurine .   ERK .   MITF .   tyrosinase .   melanogenesis.  

  • 참고문헌 (20)

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  • 이 논문을 인용한 문헌 (1)

    1. Yoon, Jin A ; Shin, Kyung-Ok ; Choi, Kyung-Soon 2015. "Studies on the Function of Taurine: Review" 한국식품영양학회지 = The Korean journal of food and nutrition, 28(5): 880~893     

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