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약학회지 = Yakhak hoeji v.51 no.6, 2007년, pp.409 - 414   피인용횟수: 5
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

마우스에서 L-Theanine의 기억력 회복능 및 Acetylcholinesterase 활성 억제
Improvement of Memory Impairment by L-Theanine Through Inhibition of Acetylcholinesterase Activity in Mice

육동연   (충북대학교 약학대학UU0001309  ); 김태일   (충북대학교 약학대학UU0001309  ); 박상기   (LG 생활건강 기술연구원CC0044723  ); 박형국   (LG 생활건강 기술연구원CC0044723  ); 윤여경   (LG 생활건강 기술연구원CC0044723  ); 홍진태   (LG 생활건강 기술연구원CC0044723  );
  • 초록

    Acetylcholinesterase (AChE) plays a role in the progression of Alzheimer's disease (AD). In this study, we examined the improving effect of L-theanine, a major amino acid in Japanese green tea (Camellia sinensis) on the scopolamine (1 mg/kg/mouse)-induced memory dysfunction in mice. Treatment with L-theanine (2, 4 mg/kg/mouse p.o.) in the drinking water for 7 days reversed the scopolamine-induced latency time and distance in the water maze test, latency time in the passive avoidance test, and inhibited AChE activity. This study suggests that L-theanine may be a useful agent for prevention of progression of AD.


  • 주제어

    theanine .   Alzheimer's disease .   memory .   acetylcholinesterase.  

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  • 이 논문을 인용한 문헌 (5)

    1. Kim, Tae-Il ; Yuk, Dong-Yeon ; Park, Sang-Ki ; Park, Hyoung-Kook ; Yoon, Yeo-Kyeung ; Hong, Jin-Tae 2008. "Improvement of Memory Impairment of Green Tea Extract/L-Theanine Through Inhibition of Secretase Activity and Cell Death In Vivo" 약학회지 = Yakhak hoeji, 52(5): 384~393     
    2. 2011. "" Journal of medicinal food, 14(4): 334~343     
    3. Sung, Sun-Heui ; Lee, Su-Kyoung ; Kang, Ok-Hwa ; Kwon, Dong-Yeul ; Chong, Myong-Soo ; Lee, Ki-Nam 2011. "Anti-allergic Activity of Dojuk-San Ethanol Extract" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 25(3): 438~444     
    4. Ryu, Jehkwang ; Jo, Young-Hong ; Chang, Seong-Jun ; Lee, Bae-Jin 2016. "Memory-improving Effects of Fermented Sea Tangle Saccharina japonica in Normal Mice" 한국수산과학회지 = Korean journal of fisheries and aquatic sciences, 49(2): 131~136     
    5. Ryu, Jehkwang ; Jo, Young-Hong ; Chang, Seong-Jun ; Lee, Bae-Jin 2016. "Memory-improving Effects of Fermented Sea Tangle Saccharina japonica in Normal Mice" 한국수산과학회지 = Korean journal of fisheries and aquatic sciences, 49(2): 131~136     

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