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약학회지 = Yakhak hoeji v.51 no.6, 2007년, pp.476 - 481   피인용횟수: 5
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

$18{\beta}$-Glycyrrhetinic Acid의 항 감염성관절염효과
Effect of $18{\beta}$-Glycyrrhetinic Acid on Septic Arthritis Caused by Candida albicans

한용문   (동덕여자대학교 약학대학 면역 미생물학교실UU0000457  );
  • 초록

    A polymorphic fungus, Candida albicans, causes various forms of infections such as disseminated candidiasis and vaginitis. Recent reports indicate that the fungus is a main etiological agent for the arthritis. In search of new sources for treatment of the fungal arthritis, we examined $18{\beta}$ -glycyrrhetinic acid ( $18{\beta}$ -GA) against C. albicans-caused septic arthritis. The compound is isolated from Glycyrrhizae Radix that is known to have various immunomodulating activities and is one of the most popular herbal medicines. For induction of animal model of a septic arthritis, mice were given an emulsion form of C. albicans cell wall mixed with Complete Freund's Adjuvant (CFA) via footpad-injection. To determine prophylactic and therapeutic effects, the component was given to the animals before or after the induction of the arthritis, respectively. Data showed that intraperitoneal administration of $18{\beta}$ -GA resulted in reduction of the inflammation, indicating the component had both prophylactic and therapeutic activities. For investigation of mechanism of the $18{\beta}$ -GA, inhibitory effects on NO (nitiric oxide) and on T-lymphocyte proliferation were determined. Results demonstrated that $18{\beta}$ -GA suppressed NO production from LPS (lipopolysaccharide)-treated macrophages and also inhibited proliferation of Con A (concanavalin A)activated T-cells. Taken together, $18{\beta}$ -GA, a pentacyclic triterpene, has anti-arthritic activity against C. albicans-caused septic arthritis, possibly by blocking NO production and T-cell suppression.


  • 주제어

    septic arthritis .   C.   albicans .   $18{\beta}$-GA .   immunomodulating .   inflammation .   NO .   T-cells .   mice.  

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  • 이 논문을 인용한 문헌 (5)

    1. Han, Yong-Moon 2008. "$18{\beta}$-Glycyrrhetinic Acid Induces Protective Anti-Candida albicans Antibody by Its Immunoadjuvant Activity" 약학회지 = Yakhak hoeji, 52(6): 494~499     
    2. Han, Yong-Moon 2010. "Immunoadjuvant Activity of Chlorogenic Acid" 약학회지 = Yakhak hoeji, 54(6): 494~499     
    3. Kim, Ha-Yan ; Kim, Song-Yi ; Lee, Jue-Hee ; Han, Yong-Moon 2011. "Antitumor Effect of $18{\beta}$-Glycyrrhetinic Acid against Human Tumor Xenografts Caused by A549 Cancer Cell" 약학회지 = Yakhak hoeji, 55(1): 39~44     
    4. Mo, Hwang Sung ; Park, Hong Woo ; Jang, In Bae ; Yu, Jin ; Park, Kee Choon ; Hyun, Dong Yun ; Lee, Eung Ho ; Kim, Ki Hong 2014. "Effect of Sowing Density and Number of Seeds Sown on Panax ginseng C. A. Meyer Seedling Stands under Direct Sowing Cultivation in Blue Plastic Greenhouse" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 22(6): 469~474     
    5. Han, Yongmoon ; Kim, Jeonghyeon 2015. "Therapeutic Effect of 18β-Glycyrrhetinic Acid on HT-29 Cancer Cell in a Murine Xenograft Model" 약학회지 = Yakhak hoeji, 59(4): 164~169     

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