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Nutrition research and practice v.1 no.4, 2007년, pp.247 - 253   피인용횟수: 1
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Alpha-Tocopherol Transfer Protein (${\alpha}$-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice

Lim, Yun-Sook   (Department of Food and Nutrition, Kyung Hee UniversityUU0001575  ); Traber, Maret G.   (Department of Nutrition and Food Management, Linus Pauling Institute, Oregon State UniversityUU0014698  );
  • 초록

    Alpha-tocopherol transfer protein ( ${\alpha}$ -TTP) is a liver cytosolic transport protein that faciliates ${\alpha}$ -tocopherol ( ${\alpha}$ -T) transfer into liver secreted plasma lipoproteins. Genetic defects in ${\alpha}$ -TTP, like dietary vitamin E deficiency, are associated with infertility, muscular weakness and neurological disorders. Both human and ${\alpha}$ -TTP deficient ( ${\alpha}-TTP^{-/-}$ ) mice exhibit severe plasma and tissue vitamin E deficiency that can be attenuated by sufficient dietary ${\alpha}$ -T supplementations. In this review, we summarize the literature concerning studies utilizing the ${\alpha}-TTP^{-/-}$ mice. Levels of vitamin E in the ${\alpha}-TTP^{-/-}$ mice do not appear to be directly related to the amounts of dietary ${\alpha}$ -T or to the levels of ${\alpha}$ -TTP protein in tissues. The ${\alpha}-TTP^{-/-}$ mice appear to present a good model for investigating the specific role of ${\alpha}$ -T in tissue vitamin E metabolism. Furthermore, ${\alpha}-TTP^{-/-}$ mice appear to be useful to elucidate functions of ${\alpha}$ -TTP beyond its well recognized functions of transferring ${\alpha}$ -T from liver to plasma lipoprotein fractions.


  • 주제어

    ${\alpha}$-tocopherol .   ${\alpha}$-tocopherol transfer protein .   vitamin E.  

  • 참고문헌 (53)

    1. Boscoboinik D, Szewczyk A & Azzi A (1991a). Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Arch Biochem Biophys 286:264-269 
    2. Boscoboinik D, Szewczyk A, Hensey C & Azzi A (1991b). Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. J Biol Chem 266:6188-6194 
    3. Copp RP, Wisniewski T, Hentati F, Larnaout A, Ben Hamida M & Kayden HJ (1999). Localization of alpha-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders. Brain Res 822:80-87 
    4. Muller-Schmehl K, Beninde J, Finckh B, Florian S, Dudenhausen JW, Brigelius-Flohe R & Schuelke M (2004). Localization of alphatocopherol transfer protein in trophoblast, fetal capillaries' endothelium and amnion epithelium of human term placenta. Free Radic Res 38:413-420 
    5. Packer L (1991). Protective role of vitamin E in biological systems. Am J Clin Nutr 53:1050S-1055S 
    6. Sen A & Mukherjea M (1998). Modulation of bilayer fluidity by lipid peroxidation of human placental syncytiotrophoblast membranes during embryogenesis. Indian J Biochem Biophys 35:216-223 
    7. Tanito M, Yoshida Y, Kaidzu S, Chen ZH, Cynshi O, Jishage K, Niki E & Ohira A (2007). Acceleration of age-related changes in the retina in alpha-tocopherol transfer protein null mice fed a Vitamin E-deficient diet. Invest Ophthalmol Vis Sci 48:396-404 
    8. Traber MG (1999). Vitamin E. p. 347-361 in ME Shils, Olson, J.A., Shike, M. & Ross, A.C., eds, ed. Modern Nutrition in Health and Disease. Williams & Willkins, Baltimore 
    9. Traber MG, Siddens LK, Leonard SW, Schock B, Gohil K, Krueger SK, Cross CE & Williams DE (2005). Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gammatocopherol diets. Free Radic Biol Med 38:773-785 
    10. Ban R, Takitani K, Kim HS, Murata T, Morinobu T, Ogihara T & Tamai H (2002). alpha-Tocopherol transfer protein expression in rat liver exposed to hyperoxia. Free Radic Res 36:933-938 
    11. Beharka A, Redican S, Leka L & Meydani SN (1997). Vitamin E status and immune function. Methods Enzymol 282:247-263 
    12. Gohil K, Godzdanker R, O'Roark E, Schock BC, Kaini RR, Packer L, Cross CE & Traber MG (2004). {alpha}-Tocopherol Transfer Protein Deficiency in Mice Causes Multi-Organ Deregulation of Gene Networks and Behavioral Deficits with Age. Ann N Y Acad Sci 1031:109-126 
    13. Hoshino M, Masuda N, Ito Y, Murata M, Goto J, Sakurai M & Kanazawa I (1999). Ataxia with isolated vitamin E deficiency: a Japanese family carrying a novel mutation in the alpha-tocopherol transfer protein gene. Ann Neurol 45:809-812 
    14. Panagabko C, Morley S, Neely S, Lei H, Manor D, & Atkinson J (2002). Expression and refolding of recombinant human alphatocopherol transfer protein capable of specific alpha-tocopherol binding. Protein Expr Purif 24:395-403 
    15. Doerflinger N, Linder C, Ouahchi K, Gyapay G, Weissenbach J, Le Paslier D, Rigault P, Belal S, Ben Hamida C & Hentati F et al. (1995). Ataxia with vitamin E deficiency: refinement of genetic localization and analysis of linkage disequilibrium by using new markers in 14 families. Am J Hum Genet 56:1116-1124 
    16. Oommen S, Vasu VT, Leonard SW, Traber MG, Cross CE & Gohil K (2007). Genome wide responses of murine lungs to dietary alpha-tocopherol. Free Radic Res 41:98-109 
    17. Schuelke M, Elsner A, Finckh B, Kohlschutter A, Hubner C & Brigelius-Flohe R (2000). Urinary alpha-tocopherol metabolites in alpha-tocopherol transfer protein-deficient patients. J Lipid Res 41:1543-1551 
    18. Gohil K, Oommen S, Vasu VT, Aung HH & Cross CE (2007). Tocopherol transfer protein deficiency modifies nuclear receptor transcriptional networks in lungs: Modulation by cigarette smoke in vivo. Mol Aspects Med 
    19. Min KC, Kovall RA & Hendrickson WA (2003). Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency. Proc Natl Acad Sci USA 100:14713-14718 
    20. Trigatti B, Rigotti A & Krieger M (2000). The role of the highdensity lipoprotein receptor SR-BI in cholesterol metabolism. Curr Opin Lipidol 11:123-131 
    21. Kaempf-Rotzoll DE, Igarashi K, Aoki J, Jishage K, Suzuki H, Tamai H, Linderkamp O & Arai H (2002). Alpha-tocopherol transfer protein is specifically localized at the implantation site of pregnant mouse uterus. Biol Reprod 67:599-604 
    22. Yokota T, Shiojiri T, Gotoda T, Arita M, Arai H, Ohga T, Kanda T, Suzuki J, Imai T, Matsumoto H, Harino S, Kiyosawa M, Mizusawa H & Inoue K (1997). Friedreich-like ataxia with retinitis pigmentosa caused by the His101Gln mutation of the alphatocopherol transfer protein gene. Ann Neurol 41:826-832 
    23. Food and Nutrition Board & Institute of Medicine (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington. USA 
    24. Schock BC, Van der Vliet A, Corbacho AM, Leonard SW, Finkelstein E, Valacchi G, Obermueller-Jevic U, Cross CE & Traber MG (2004). Enhanced inflammatory responses in alpha-tocopherol transfer protein null mice. Arch Biochem Biophys 423:162-169 
    25. Kaempf-Rotzoll DE, Horiguchi M, Hashiguchi K, Aoki J, Tamai H, Linderkamp O & Arai H (2003). Human placental trophoblast cells express alpha-tocopherol transfer protein. Placenta 24:439-444 
    26. Leonard SW, Terasawa Y, Farese RV, Jr. & Traber MG (2002). Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice. Am J Clin Nutr 75:555-560 
    27. Ouahchi K, Arita M, Kayden H, Hentati F, Ben Hamida M, Sokol R, Arai H, Inoue K, Mandel JL & Koenig M (1995). Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet 9:141-145 
    28. Yokota T, Uchihara T, Kumagai J, Shiojiri T, Pang JJ, Arita M, Arai H, Hayashi M, Kiyosawa M, Okeda R & Mizusawa H (2000). Postmortem study of ataxia with retinitis pigmentosa by mutation of the alpha-tocopherol transfer protein gene. J Neurol Neurosurg Psychiatry 68:521-525 
    29. Traber MG, Lane JC, Lagmay NR & Kayden HJ (1992). Studies on the transfer of tocopherol between lipoproteins. Lipids 27:657-663 
    30. Goodwin B, Redinbo MR & Kliewer SA (2002). Regulation of cyp3a gene transcription by the pregnane x receptor. Annu Rev Pharmacol Toxicol 42:1-23 
    31. Ricciarelli R, Tasinato A, Clement S, Ozer NK, Boscoboinik D & Azzi A (1998). alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state. Biochem J 334:243-249 
    32. Arita M, Sato Y, Miyata A, Tanabe T, Takahashi E, Kayden HJ, Arai H & Inoue K (1995). Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. Biochem J 306:437-443 
    33. Hosomi A, Goto K, Kondo H, Iwatsubo T, Yokota T, Ogawa M, Arita M, Aoki J, Arai H & Inoue K (1998). Localization of alpha-tocopherol transfer protein in rat brain. Neurosci Lett 256:159-162 
    34. Traber MG & Arai H (1999). Molecular mechanisms of vitamin E transport. Annu Rev Nutr 19:343-355 
    35. Gohil K, Schock BC, Chakraborty AA, Terasawa Y, Raber J, Farese RV, Jr., Packer L, Cross CE & Traber MG (2003). Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. Free Radic Biol Med 35:1343-1354 
    36. Panagabko C, Morley S, Hernandez M, Cassolato P, Gordon H, Parsons R, Manor D & Atkinson J (2003). Ligand specificity in the CRAL-TRIO protein family. Biochemistry 42:6467-6474 
    37. Traber MG, Sokol RJ, Burton GW, Ingold KU, Papas AM, Huffaker JE & Kayden HJ (1990). Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver. J Clin Invest 85:397-407 
    38. Vasu VT, Hobson B, Gohil K & Cross CE (2007). Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP (-/-)). FEBS Lett 581:1572-1578 
    39. Mariotti C, Gellera C, Rimoldi M, Mineri R, Uziel G, Zorzi G, Pareyson D, Piccolo G, Gambi D, Piacentini S, Squitieri F, Capra R, Castellotti B & Di Donato S (2004). Ataxia with isolated vitamin E deficiency: neurological phenotype, clinical follow-up and novel mutations in TTPA gene in Italian families. Neurol Sci 25:130-137 
    40. Qanungo S, Sen A & Mukherjea M (1999). Antioxidant status and lipid peroxidation in human feto-placental unit. Clin Chim Acta 285:1-12 
    41. Cuddihy SL, Musiek ES, Morrow JD & Dugan LL (2004). Long-term vitamin e deficiency in mice decreases superoxide radical production in brain. Ann N Y Acad Sci 1031:428-431 
    42. Jishage K, Arita M, Igarashi K, Iwata T, Watanabe M, Ogawa M, Ueda O, Kamada N, Inoue K, Arai H & Suzuki H (2001). Alpha-tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice. J Biol Chem 276:1669-1672 
    43. Morley S, Panagabko C, Shineman D, Mani B, Stocker A, Atkinson J & Manor D (2004). Molecular determinants of heritable vitamin E deficiency. Biochemistry 43:4143-4149 
    44. Das P & Chowdhury M (1999). Vitamin E-deficiency induced changes in ovary and uterus. Mol Cell Biochem 198:151-156 
    45. Desrumaux C, Risold PY, Schroeder H, Deckert V, Masson D, Athias A, Laplanche H, Le Guern N, Blache D, Jiang XC, Tall AR, Desor D & Lagrost L (2005). Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice. Faseb J 19:296-297 
    46. Mardones P, Strobel P, Miranda S, Leighton F, Quinones V, Amigo L, Rozowski J, Krieger M & Rigotti A (2002). Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice. J Nutr 132:443-449 
    47. Yokota T, Igarashi K, Uchihara T, Jishage K, Tomita H, Inaba A, Li Y, Arita M, Suzuki H, Mizusawa H & Arai H (2001). Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci USA 98:15185-15190 
    48. Evans HM & Bishop KS (1922). On the existence of a hitherto unrecognizd dietary factor essential for reproduction. Science 56:650 
    49. Meier R, Tomizaki T, Schulze-Briese C, Baumann U & Stocker A (2003). The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein. J Mol Biol 331:725-734 
    50. Mustacich DJ, Leonard SW, Devereaux MW, Sokol RJ & Traber MG (2006). Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats. Free Radic Biol Med 41:1069-1078 
    51. Catignani GL (1975). An alpha-tocopherol binding protein in rat river cytoplasm. Biochem Biophys Acta 497:349-357 
    52. Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H & Inoue K (1997). Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 409:105-108 
    53. Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, Packer L, Traber MG & Farese RV, Jr. (2000). Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A 97:13830-13834 
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