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인체상피세포를 이용한 Vinyl acetate의 발암성 및 작용기전

조준현   (경북대학교 치과대학 구강악안면외과학교실UU0000096  ); 김진수   (경북대학교 치과대학 구강악안면외과학교실UU0000096  );
  • 초록

    Vinyl acetate has been widely used for the manufacture of polyvinyl alcohol emulsion, which is primary ingredient of adhesive, paints, textile, paperboard coatings, etc. Since these products are plentiful and frequently used around us, workers and consumers are at health risk. International Agency for Research on Cancer(IARC) classified vinyl acetate as group 2B(possibly carcinogenic to humans). Among the organs targeted, the oral cavity is the most vulnerable organ affected by the carcinogenic effects of vinyl acetate. Since the origin of most of oral cancer is derived from the epithelial cells, it is important to understand the carcinogenic potential of vinyl acetate in human epithelial cells. Thus, the present study has attempted to utilize the immortalized human epithelial cell model to assess the carcinogenic potency of this chemical and to understand the underlying mechanisms.

  • 주제어

    Vinyl acetate .   Neoplastic transformation .   Human epithelial cell.  

  • 참고문헌 (26)

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    1. 1977 "METAL MESH 보철물을 이용한 편측하악골 절제술후 조기 재형성의 증예보고" 大韓齒科醫師協會誌 = The journal of the Korean dental association 15 (2): 127~132    
    2. 1985 "교근의 휴지기에 관한 근전도학적 관찰" 대한구강내과학회지 = Korean journal of oral medicine 10 (1): 105~112    
    3. 1985 "쇄골두개이골증의 일례" 大韓齒科醫師協會誌 = The journal of the Korean dental association 23 (6): 499~508    
    4. 1987 "교합안전장치가 측두하악장애 환자의 교근의 휴지기에 미치는 영향" 대한구강내과학회지 = Korean journal of oral medicine 12 (1): 95~103    
    5. 1987 "냉동처리한 자가골 재이식에 관한 연구" 大韓齒科醫師協會誌 = The journal of the Korean dental association 25 (5): 465~477    
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    7. 1989 "하악과두의 골증식체 평가에 있어서 transmaxillary 촬영법과 transcranial 촬영법의 비교" 齒科放射線 19 (1): 123~136    
    8. 1989 "하악골 Malunion에 따른 Transverse Mandibular Deficiency에 대하여 split and Replantation of Corticocancellous Bone Graft를 이용한 외과적 교정술의 증례보고" 대한악안면성형외과학회지 = Journal of the Korean academy of maxillo-facial plastic surgery 11 (1): 249~254    
    9. 1990 "파노라마 촬영시 두경부 주요기관에 대한 흡수선량 분포" 齒科放射線 20 (2): 253~264    
    10. 1990 "관전압 변화에 다른 실험적 골결손부의 방사선사진상의 판독" 齒科放射線 20 (2): 265~276    

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