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가토 두개골 결손부에 이식된 새로운 합성 골이식재의 골치유능력
BONE HEALING CAPACITY OF THE NEW FLUORIDATED HYDROXYAPATITE IN THE RABBIT CRANIUM DEFECT

노규섭   (단국대학교 치과대학 구강악안면외과학교실UU0000336  ); 한세진   (단국대학교 치과대학 구강악안면외과학교실UU0000336  ); 김철환   (단국대학교 치과대학 구강악안면외과학교실UU0000336  ); 김경욱   (단국대학교 치과대학 구강악안면외과학교실UU0000336  );
  • 초록

    The bone graft materials are grossly divided into autogenous bone, allogenic bone, xenogenic bone, and alloplastic material. Among the various allogenic graft materials, hydroxyapatite( $Ca_{10}(PO_4)_6(OH)_2$ , HA), the main inorganic phase of human hard tissue, is widely used as a repair material for bones. When HA applied to bony defect, however, it may be encapsulated with fibrous tissue and floated in the implanted area by the lack of consolidation. Fluoridated hydroxyapatite( $Ca_{10}(PO_4)_6(OH)_2$ , FHA), where F- partially replaces the OH- in the hydroxyapatite, is considered as an alternative material for bone repair due to its solubility and biocompatibility. This study was designed to find out the bone healing capacity of FHA newly produced as a nanoscale fiber in the laboratory. We implanted HA and FHA in the rabbit cranium defect and histologically analysed the specimen. The results were as follows. 1. In the 4 weeks, fibrous connective tissue and little bone formation around materials of the experimental group I implanted HA were observed. In the experimental group II implanted FHA, newly formed bone around materials were observed. 2. In the 8 weeks, the amount of newly formed and matured bone of the experimental group II was more than the experimental group I and control group. From the results obtained, we suggest that FHA, newly synthesized, is relatively favorable bone substitute with bioconpatibility and has better bone healing capacity than pure HA.


  • 주제어

    Bone graft .   Alloplast .   Calvaria.  

  • 참고문헌 (25)

    1. Boyne PJ: Induction of bone repair by various bone grafting materials, hard tissue growth, repair and remineralization. Ciba Found Symp 1973;11:121 
    2. Costantino PD, Friedman CD: Synthetic bone graft substitutes. Otolaryngol Clin North Am 1994;27:1037 
    3. Papay FA, Morales L, Ahmed OF, et al.: Comparison of ossification of demineralized bone, hydroxyapatite, Gelfoam, and bone wax in cranial defect repair. J Craniofac Surg 1996;7:347 
    4. Glowacki J, Mulliken JB: Induced osteogenesis for repair and construction in the craniofacial region. Plast Reconstr Surg 1980;65:553 
    5. Kim HW, Lee EJ, Kim HE, Salih V, et al.: Effect of fluoridation of hydroxyapatite in hydroxyapatite-polycaprolactone composites on osteoblast activity. Biomaterials 2005;26:4395-4404 
    6. Prokic B, Carranza FA, Kenny EB, et al.: Comparative clinical study of porous hydroxyapatite and decalcified freeze-dried bone in human periodontal defects. J Periodontol 1990;61:399 
    7. Okazaki M. Miake Y, Tohda H, et al.: Functionally graded fluoridated apatites. Biomaterials 1999;20:1421-6 
    8. Dzenis Y: Spinning continuous fibers for nanotechnology.: Science 2004;304:1917-1919 
    9. Moreno EC, Kresak M, Zahradnik RT: Fluoridated hydroxyapatite solubility and caries formation. Nature 1974;247:64-65 
    10. Laurencin CT, Ambrosio AMA, Borden MD, et al.: Tissue engineeIing: orthopedic applications. Annu Rev Biomed Eng 01:19-46, 1999 
    11. Kim HW, Kim HE, Salih V, et al.: Hydroxyapatite and fluor-hydroxyapatite layered film on titanium processed by a sol-gel route for hard-tissue implants. J Biomed Mater Res Part B: Appl Biomater 2004;71B:66-76 
    12. Kim HW, Li LH, Koh YH, et al.: Sol-gel preparation and properties of fluoride-substituted hydroxyapatite powders. J Am Ceram Soc 2004;87:1939-1944 
    13. Li D, Xia Y: Electrospinning of nanofibers: reinventing the wheel? Adv Mater 2004;16:1151-1170 
    14. Burstein AH, Einhorn TA, Kopman CR, et al.: The healing of segmental bone defects induced by demineralized bone matrix. J Bone Joint Surg 1984;66:274 
    15. Jarcho M: Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop 1981;157:259 
    16. Masters DH: Implants. Bone and bonesubstitutes. Calif Dent Assoc J 1988;16:56 
    17. Wagner JR: A 3 1/2-year clinical evaluation of resorbable hydroxylapatite osteogen (HA Resorb) used for sinus lift augmentations in conjunction with the insertion of endosseous implants. J Oral Implantol 1991;17:152 
    18. LeGeros RZ, Silverstone LM, Daculsi G, et al.: In vitro caries-like lesion formation in F-containing tooth enamel. J Dent Res 1985;62:138-144 
    19. Driessens FCM: Relation between apatite solubility and anticariogenic: effect of fluoride. Nature 1973;243:420-1 
    20. Kim H: J Biomed Mater Res B Appl Biomater 2006;77(2):323-8 
    21. Dee KC, Puleo DA, Bizios R: An introduction to tissue-biomaterial interactions. New York, NY: John Wiley & Sons; 2002 
    22. Marie PJ, De Vernejoul MC, LomIi A: Stimulation of bone formation in osteoporosis patients treated with fluoride associated with increased DNA synthesis by osteoblastic cells in vitro. J Bone Miner Res 1992;7:103-113 
    23. Glowacki J, Kaban LB, Mulliken JB: Treatment of jaws defects with demineralized bone implants. J Oral Maxillfac Surg 1982;40:623 
    24. Glowacki J, Mulliken JB: Demineralized bone implants. Clin Plast Surg 1985;12:233 
    25. Wagner JR: A clinical and histological case study using resorbable hydroxyapatite for the repair of osseous defects prior to endosseous implant surgery. J Oral Implantol 1989;15:186 
  • 이 논문을 인용한 문헌 (1)

    1. Ahn, Hyo-Joon ; Han, Se-Jin ; Kim, Kyung-Wook 2011. "Bone regeneration of the fluoridated hydroxyapatite and the bio-glass in the rabbit cranium defect model" 大韓口腔顎顔面外科學會誌 = Journal of the Korean Association of Oral and Maxillofacial Surgeons, 37(5): 380~385     

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