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CHEMILUMINESCENCE IN DIAGNOSIS OF ORAL LICHEN PLANUS

명훈   (서울대학교 치과대학 구강악안면외과학교실UU0000691  ); 정해석   (서울대학교 치과대학 구강악안면외과학교실UU0000691  ); 이현선   (서울대학교 치과병원 임상치의학연구소HH0045156  ); 홍순민   (한림대학교 의과대학 강동성심병원 구강악안면외과UU0001493  ); 김명진   (서울대학교 치과대학 구강악안면외과학교실UU0000691  );
  • 초록

    Purpose: This study was conducted in order to evaluate how chemiluminescent lighting( $ViziLite^{(R)}$ ) could increase the sharpness of margin and contrast to normal mucosa in the diagnosis of oral lichen planus(OLP), the most frequent oral premalignant lesion, compared with direct visual inspection under incandescent light. Methods: 41 consecutive patients, diagnosed to have OLP with visual inspection under incandescent light, were further examined with chemiluminescent light. The degrees of margin sharpness and lesion contrast were ranked on a scale from 1 to 3 for all patients under visual inspection and chemiluminescent light. The presence of additional lesion only detected by chemiluminescent light, complication, and discomfort were checked for each patient. After both screening tests, biopsy specimens were harvested from all patients with scalpels and histopathologic assessments were done. Results: All 41 patients were diagnosed to have OLP by both visual inspection and chemiluminescent light examination. This result was definitively diagnosed by histopathology. Degrees of margin sharpness and lesion contrast were increased by chemiluminescent light compared with visual inspection, but only the difference of lesion contrast was statistically significant. In 22.0% of patients, additional lesions were detected and 88.9% of them were diagnosed to have OLP histopathologically. 17.1% of patients noted discomfort and 9.8% of patients showed complications after chemiluminescent test. Conclusion: Chemiluminescent light may not be proper for the screen test of oral cancer or premalignant lesion but showed some possibility for additional diagnostic tool for definitively diagnosed patients in determination of lesion margin and scope.


  • 주제어

    Luminescence .   Diagnosis .   Oral lichen planus .   Squamous cell carcinoma.  

  • 참고문헌 (32)

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