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F344 rats를 이용 망간 및 철 화합물의 체내 흡수와 생식기 및 운동성에 미치는 영향
Effect of Mn and Fe Compound on the Absorption in the Body and Genital Organs, Activity with F344 Rats

김현영   (산업안전보건연구원 화학물질안전보건센터  ); 이성배   (산업안전보건연구원 화학물질안전보건센터  ); 한정희   (산업안전보건연구원 화학물질안전보건센터  ); 최성봉   (산업안전보건연구원 화학물질안전보건센터  ); 강민구   (산업안전보건연구원 화학물질안전보건센터  ); 이채관   (인제대학교 산업의학연구소 및 부산백병원 산업의학과UU0001067  );
  • 초록

    This study aimed to examine the harmful effects of Mn and Fe, which may be generated as dust or fume in the industrial sites, on the body and genital organs by their inhalation. It is intended to find the characteristics and differences of the hazardousness by inhaling a single and the mixed materials of Mn and Fe. Male F344 rats were divided into the control group and 3 exposed groups on the basis of the test material compound (Mn $1.5mg/m^3$ , Mn 1.5 and Fe $3.0mg/m^3$ , Fe $3.0mg/m^3$ ). The 4 groups were divided into 4 subgroups again on the basis of the exposure period (4 and 13 weeks) and the recovery period (4 and 13 weeks). The exposure condition was 6 hours a day, 5 days a week for the whole body. Clinical tests including changes in weight and feed rate, blood biochemical test, motility change, changes in the number and the amount of spermatozoon (sperm count), daily sperm production (DSP), deformity test of spermatozoon and changes in the accumulation of Mn and Fe in blood and internal organs were performed. Motility was reduced by Mn exposure. Especially, the effect of Mn was exposure period responsible. By mixing with Fe, no significant change in motility Mn and Fe accumulation in organs was observed. Sperm count and daily sperm production (DSP) were decreased by Mn. Additional effect like the reduction of sperm count and DSP, and delayed restoration of sperm count and DSP during the recovery period were observed in the mixed exposure group. These results indicate that Mn and Fe may affect the motility reduced and has male reproductive toxicity. Mixed exposure of Mn and Fe lead to synergic effects on the male reproductive toxicity.


  • 주제어

    Mn .   Fe .   Inhalation Toxicity .   Manganese toxicity.  

  • 참고문헌 (31)

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