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Molecular & cellular toxicology v.3 no.4, 2007년, pp.238 - 245   피인용횟수: 3
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Proteomic Analysis of Differentially Expressed Proteins in Human Lung Cells Following Formaldehyde Treatment

Jeon, Yu-Mi   (Department of Biotechnology, SoonChunHyang UniversityUU0000848  ); Ryu, Jae-Chun   (Cellular and Molecular Toxicology Laboratory, Korea Institute of Science and TechnologyCC0186926  ); Lee, Mi-Young   (Department of Biotechnology, SoonChunHyang UniversityUU0000848  );
  • 초록

    Chronic formaldehyde inhalation studies have suggested its relativity to teratogenicity, cancer incidence, neurodegenerative and vascular disorders. Many toxicological data on the formaldehyde toxicity are available, but proteomic results showing complete protein profiles are limited. Therefore, alterations of protein expression patterns upon formaldehyde treatment were investigated in the human lung epithelial cell line. Differentially expressed proteins following formaldehyde treatment were analyzed on 2-dimensional gels, and further analyzed by MALDI-TOF to identify the proteins. Among the identified proteins, 24 proteins were notably up-regulated and 6 proteins were down-regulated. In particular, cytoskeleton related protein named vinculin and Rho GDP dissociation inhibitor which plays a key role in apoptosis increased remarkably.


  • 주제어

    Formaldehyde .   Human lung epithelial cell .   Toxicoproteomics.  

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  • 이 논문을 인용한 문헌 (3)

    1. 2008. "" 한국응용생명화학회지 = Journal of the Korean Society for Applied Biological Chemistry, 51(4): 269~275     
    2. 2008. "" Molecular & cellular toxicology, 4(3): 253~259     
    3. 2009. "" BMB reports, 42(7): 456~461     

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