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Molecular & cellular toxicology v.3 no.4, 2007년, pp.299 - 305   피인용횟수: 4
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Toxicoproteomic Analysis of Differentially Expressed Proteins in Rat Liver by DEHP

Son, Bu-Soon   (Department of Environmental Health Scinece, SoonChunHyang UniversityUU0000848  ); Seong, Ah-Reum   (Department of Biotechnology, SoonChunHyang UniversityUU0000848  ); Park, Seul-Ki   (Department of Biotechnology, SoonChunHyang UniversityUU0000848  ); Kim, Wan-Jong   (Department of Life Science, SoonChunHyang UniversityUU0000848  ); Ryu, Jae-Chun   (Cellular and Molecular Toxicology Laboratory, Korea Institute of Science and TechnologyCC0186926  ); Lee, Mi-Young   (Department of Biotechnology, SoonChunHyang UniversityUU0000848  );
  • 초록

    The endocrine disrupting chemical, di (2-ethylhexyl) phthalate (DEHP) is a plasticizer used in polyvinyl chloride products ubiquitous in our daily lives. DEHP has potentially adverse effects on the liver, kidney, lung, heart, reproductive organs and endocrine systems. Many toxicological data on the DEHP toxicity have been stated, but complete protein profiles have not yet been reported. In this study, DEHP-induced oxidative DNA damage in rat lymphocyte was evaluated by Comet assay (single-cell gel electrophoresis) for the first time. Moreover, DEHP-induced protein profile alterations were examined in rat liver by using toxicoproteomic tools. 34 protein spots in the liver were identified to be significantly deregulated by DEHP on the 2-dimensional gel. Among them, 20 spots were up-regulated and 14 spots down-regulated by DEHP.


  • 주제어

    DEHP .   Rat liver .   Toxicoproteomics.  

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  • 이 논문을 인용한 문헌 (4)

    1. 2008. "" Molecular & cellular toxicology, 4(4): 300~306     
    2. 2008. "" Molecular & cellular toxicology, 4(3): 253~259     
    3. 2009. "" Molecular & cellular toxicology, 5(3): 243~249     
    4. 2011. "" Animal cells and systems, 15(2): 107~114     

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