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Molecular & cellular toxicology v.3 no.4, 2007년, pp.320 - 325  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The Relationship DNA Methylation of $p16^{INK4a}$ and Colorectal Cancer

Hong, Young-Seoub   (Department of Preventive Medicine, College of Medicine, Dong-A UniversityUU0000480  ); You, Chang-Hun   (Department of Preventive Medicine, College of Medicine, Dong-A UniversityUU0000480  ); Roh, Mee-Sook   (Department of Pathology, College of Medicine, Dong-A UniversityUU0000480  ); Kim, Na-Young   (Department of Preventive Medicine, College of Medicine, Dong-A UniversityUU0000480  ); Lee, Kyung-Eun   (Department of Pathology, College of Medicine, Dong-A UniversityUU0000480  ); Kim, Hyo-Jun   (Department of Preventive Medicine, College of Medicine, Dong-A UniversityUU0000480  ); Lee, Hyun-Jae   (Department of Occupational Medicine, Dong-A UniversityUU0000480  ); Kwak, Jong-Young   (Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A UniversityUU0000480  ); Kim, Joon-Youn   (Department of Preventive Medicine, College of Medicine, Dong-A UniversityUU0000480  );
  • 초록

    Promoter hypermethylation of the $p16^{INK4a}$ gene was investigated in 52 sets of samples of tumor tissue and adjacent normal tissue from Korean patients with colorectal cancer, using the proposed modified the Real-time PCR/SYBR Green detection method presented in this study. In normal tissue, 29 of 52 patients (56%) were methylated and in tumor tissue, 23 of 52 patients (44%) were methylated. The 34 cases (65.4%) showed a concordant DNA methylation pattern in both normal tissue and tumor tissue. Analyzing the association between the clinicopathologic features and DNA methylation status of the $p16^{INK4a}$ gene, the DNA methylation status according to by Duke's stage was different while other clinicopathological characteristics, including the age, sex, tumor stage, and histologic type of the patient were not found to be correlated with $p16^{INK4a}$ methylation. With multivariate logistic regression, it was observed that the DNA methylation status of $p16^{INK4a}$ gene in normal tissue was correlated with the DNA methylation status of the $p16^{INK4a}$ gene in tumor tissue (P=0.026). According to a Kaplan-Meier survival analysis, a difference in the survival rate by DNA methylation status was found, but it was not significant.


  • 주제어

    Hypermethylation .   $p16^{INK4a}$ .   Colorectal cancer.  

  • 참고문헌 (16)

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