본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

The recovery effect of polyacetylene constituents from Acanthopanax senticosus extracts on hepatic injury in dogs

Cho, Sung-nam    (College of Veterinary Medicine, Chungnam National University   ); Liu, Jianzhu    (Laboratory of Veterinary Internal Medicine, College of Animal Science & Veterinary Medicine, Shandong Agricultural University   ); Jun, Hyung-kyou    (College of Veterinary Medicine, Chungnam National University   ); Cho, Sung-whan    (College of Veterinary Medicine, Chungnam National University   ); Chang, Kyu-seob    (College of Agriculture & Life Science, Chungnam National University   ); Kim, Seong-ju    (College of Agriculture & Life Science, Chungnam National University   ); Kim, Young-hee    (College of Agriculture & Life Science, Chungnam National University   ); Yang, Hyo-jin    (College of Agriculture & Life Science, Chungnam National University   ); Kim, Duck-hwan    (College of Veterinary Medicine, Chungnam National University  );
  • 초록

    The present study was performed to clarify the recovery effect of polyacetylene constituents from Acanthopanax senticosus ethanol extracts on $CCl_4$ -induced acute hepatic injury in dogs. Sixteen clinically healthy dogs were divided into the control group (six dogs), and experimental group I (three dogs), II (three dogs) and III (four dogs). Acute hepatic injury was induced by single intraperitoneal injection of 1 ml/kg $CCl_4$ solution ( $CCl_4$ : olive oil = 1 : 1) after sterilization. The control group was orally administered with 10 ml of corn oil, and experimental groups I, II and III were orally administered with extracts of A. senticosus at the dose of 5, 10 and 30 mg/kg in 10 ml corn oil for seven consecutive days at 24 h after $CCl_4$ injection. We assessed changes occurring in serum ALT, AST and GGT activities on the pre, day 0, day 1, day 2, day 3, day 5 and day 7, together with the histopathological findings. In experimental group I, the significant changes in serum ALT activities were found on day 5 (p $CCl_4$ in dogs.


  • 주제어

    Acanthopanax senticosus .   $CCl_4$ .   liver .   polyacetylene.  

  • 참고문헌 (29)

    1. Choi JS, Yoon TJ, Kang KR, Lee KH, Kim WH, Suh YH, Song J, Jung MH. Glycoprotein isolated from Acanthopanax senticosus protects against hepatotoxicity induced by acute and chronic alcohol treatment. Biol Pharm Bull 2006, 29, 306-314 
    2. Davydov M, Krikorian AD. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J Ethnopharmacol 2000, 72, 345-393 
    3. Jin LH, Han SS, Choi YS. Antioxidant effects of the extracts of Acanthopanax senticosus. Korean J Pharmacogen 2002, 33, 359-363 
    4. Lin CC, Huang PC. Antioxidant and hepatoprotective effects of Acathopanax senticosus. Phytother Res 2000, 14, 489-494 
    5. Nan JX, Park EJ, Nam JB, Zhao YZ, Cai XF, Kim YH, Sohn DH, Lee JJ. Effect of Acanthopanax koreanum nakai (Araliaceae) on d-galactosamine and lipopolysaccharide-induced fulminant hepatitis. J Ethnopharmacol 2004, 92, 71-77 
    6. Park EJ, Nan JX, Zhao YZ, Lee SH, Kim YH, Nam JR, Lee JJ, Sohn DH. Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by d-galactosamine and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol. 2004, 94, 298-304 
    7. Phuong NT, Lee KA, Jeong SJ, Fu CX, Choi JK, Kim YH, Kang JS. Capillary electrophoretic method for the determination of diterpenoid isomers in Acanthopanax species. J Pharm Biomed Anal 2006, 40, 56-61 
    8. Yi JM, Hong SH, Kim JH, Kim HK, Song HJ Kim HM. Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis. J Ethnopharmacol 2002, 79, 347-352 
    9. Baranska M, Schulz H, Baranski R, Nothnagel T, Christensen LP. In situ simultaneous analysis of polyacetylenes, carotenoids and polysaccharides in carrot roots. J Agric Food Chem 2005, 53, 6565-6571 
    10. Lee S, Son D, Ryu J, Lee YS, Jung SH, Kang J, Lee SY, Kim HS, Shin KH. Anti-oxidant activities of Acanthopanax senticosus stems and their lignan components. Arch Pharm Res 2004, 27, 106-110     
    11. Matsuda H, Murakami T, Kageura T, Ninomiya K, Toguchida I, Nishida N, Yoshikawa M. Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga. Bioorg Med Chem Lett 1998, 8, 2191-2196 
    12. Kwon JW, Lee KS. Effects of an extract from A. gmelini weber on hepatotoxicity induced by CCl4 in rat-II. Some dosage effects of an extract from A. gmelini on hepatotoxicity induced by CCl4 in rats. Korean J Environ Toxicol 2002, 17, 175-185 
    13. Kim HY, Choi HS, Kim KW. Effects of saponin and ethanol extract of Pan ax ginseng against thioacetamideinduced hepatotoxicity in rats. Korean J Toxicol 1996, 12, 251-258 
    14. Kwon JW, Lee KS. Effects of an extract from A. gmelini weber on hapatotoxicity induced by CCl$_{4}$ in rats-I. Effects of an extract from A. gmelini on hepatotoxicity induced by different levels of CCl$_{4}$. Korean J Environ Toxicol 2002, 17, 161-174     
    15. Lee YS, Jung SH, Lim SS, Ji J, Lee SH, Shin KH. Effects of the water extract from the stem bark of Acanthopanax senticosus on hyperlipidemia in rats. Korean J Parmacogn 2001, 32, 103-107 
    16. Liu TP, Lee CS, Liou SS, Liu IM, Cheng JT. Improvement of insulin resistance by Acanthopanax senticosus root in Fructose-rich chow-fed rats. Clin Exp Pharmacol Physiol 2005, 32, 649-654 
    17. Zidorn C, Johrer K, Ganzera M, Schubert B, Sigmund EM, Mader J, Grell R, Ellmerer EP, Stuppner H. Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. J Agric Food Chem 2005, 53, 2518-2523 
    18. Deyama T, Nishibe S, Nakazawa Y. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin 2001, 22, 1057-1070 
    19. Kim SY, Lee HS, Ryu KS, Lee EJ, Kim YC. Protective effects of extracts of Mori cortex radicis on carbon tetrachloride-induced hepatotoxicity. Yakhak Hoeji 1999, 43, 391-396     
    20. Steinmann GG, Esperester A, Joller P. Immunopharmacological in vitro effects of Eleutherococcus senticosus extracts. Arzneimittelforschung 2001, 51, 76-83 
    21. Jung HJ, Min BS, Park JY, Kim YH, Lee HK, Bae KH. Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis. J Nat Prod 2002, 65, 897-901 
    22. Rogala E, Skopinska-Rozewska E, Sawicka T, Sommer E, Prosinska J, Drozd J. The influence of Eleuterococcus senticosus on cellular and humoral immunological response of mice. Pol J Vet Sci 2003, 6, 37-39 
    23. Yoon TJ, Yoo YC, Lee SW, Shin KS, Choi WH, Hwang SH, HA ES, Jo SK, Kim SH, Park WM. Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action. J Ethnopharmacol 2004, 93, 247-253 
    24. Stephen JB, Robert GS. Saunders Manual of Small Animal Practice. 2nd ed. pp. 824-873, Saunders, Philadelphia, 2000 
    25. Kim H, Lee YH, Kim SI. Antihepatotoxic components of Korean ginseng. Korean Biochem J 1989, 12, 12-18 
    26. Yoon TJ, Lee SW, Shin KS, Choi WH, Hwang SH, Seo SH, Kim SH, Park WM. Effect of hot water extract from Acanthopanax senticosus on systemic anaphylaxis. Korean J Food Sci Technol 2002, 32, 518-523 
    27. Glatthaar-Saalmuller B, Sacher F, Esperester A. Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Res 2001, 50, 223-228 
    28. Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 1969, 9, 419-430 
    29. Kim SJ, Chang KS. Separating of falcarinol from Acanthopanax senticosus. Korean J Food Sci Technol 2005, 37, 360-363     

 저자의 다른 논문

  • 조성남 (9)

    1. 2001 "개 난소낭종 진단 1예" Journal of veterinary clinics = 한국임상수의학회지 18 (4): 474~478    
    2. 2002 "개의 體熱에 대한 연구" Journal of veterinary clinics = 한국임상수의학회지 19 (2): 121~124    
    3. 2005 "젖소 유방염에 대한 오존가스의 치료효과" Journal of veterinary clinics = 한국임상수의학회지 22 (4): 314~317    
    4. 2005 "젖소 유방염에 대한 Ozonated oil의 치료효과" Journal of veterinary clinics = 한국임상수의학회지 22 (4): 318~321    
    5. 2006 "한국재래 산양에 자연 발생한 전염성 농포성 피부염에 대한 오존의 치료효과" Journal of veterinary clinics = 한국임상수의학회지 23 (1): 14~17    
    6. 2006 "개에 있어서 안침(眼針)에 따른 혈청 가스트린 농도의 변화" Journal of veterinary clinics = 한국임상수의학회지 23 (2): 119~122    
    7. 2006 "뇌하수체 의존성 부신피질기능항진증 이환견의 Trilostane 치료 1례" Journal of veterinary clinics = 한국임상수의학회지 23 (2): 202~206    
    8. 2007 "면역매개성 용혈성 빈혈 이환견에 발생한 혈전색전증 1례" Journal of veterinary clinics = 한국임상수의학회지 24 (2): 255~259    
  • Jun, Hyung-Kyou (23)

  • 조성환 (94)

  • 장규섭 (88)

  • 김성주 (7)

  • 김영희 (2)

  • Kim, Duck-Hwan (115)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
  • 대한수의학회 : 저널
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 이용한 콘텐츠
이 논문과 함께 출판된 논문 + 더보기