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Journal of ginseng research = 高麗人參學會誌 v.31 no.3, 2007년, pp.117 - 126   피인용횟수: 3

Therapeutic Effects of Ginseng on Psychotic Disorders

Ma, Yu-An    (Research Institute of Veterinary Medicine, Chungbuk National University   ); Eun, Jae-Soon    (College of Pharmacy, Woosuk University   ); Oh, Ki-Wan    (College of Pharmacy, Chungbuk National University  );
  • 초록

    Ginseng, the root of Panax species, a well-known herbal medicine has been used as a traditional medicine for thousands of years and is now a popular and worldwide used natural medicine. Ginseng has been used primarily as a tonic to invigorate weak bodies to help the restoration of homeostasis in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency and hepatotoxicity. Although conclusive clinical data in humans is still missing, recent research results have suggested that some of the active ingredients ginseng exert beneficial effects on central nervous system (CNS) disorders and neurodegenerative diseases, suggesting it could be used in treatment of psychotic disorders. Data from neural cell cultures and animal studies contribute to the understanding of these mechanisms that involve inhibitory effects on stress-induced corticosterone level increasing and modulating of neurontransmitters, reducing $Ca^{2+}$ over-influx, scavenging of free radicals and counteracting excitotoxicity. In this review, we focused on recently reported medicinal effects of ginseng and summarized the possibility of its applications on psychotic disorders.


  • 주제어

    Panax ginseng .   Ginsenoside .   Psychotic disorders .   Learning and memory .   Anxiolytic effect .   Sleep.  

  • 참고문헌 (103)

    1. Douki, S., Taktak, M. J., Ben, Z. S. and Cheour, M.: Therapeutic strategies in the first psychotic episode. Encephale. 25, 44-51 (1999) 
    2. Sachs, N. A., Sawa, A., Holmes, S. E., Ross, C. A., DeLisi, L. E. and Margolis, R. L.: A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder. Molecular psychiatry. 10, 758-764 (2005) 
    3. Weinberger, D. R.: Genetic mechanisms of psychosis: in vivo and postmortem genomics. Clinical Therapeutics. 27, 8-15 (2005) 
    4. Rybakowski, J., Klonowska, P., Patrzala, A. and Jaracz, J.: Psychopathology and creativity. Psychiatria Polska. 40, 1033-1049 (2006) 
    5. Svensson, T. H.: Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs. Brain Research Reviews. 31, 320-329 (2000) 
    6. Tsigos, C. and Chrousos, G. P.: Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J. of Psychosomatic Research. 53, 865-871 (2002) 
    7. Pijl, H. and Meinders E. A.: Modulation of monoaminergic neural circuits: potential for the treatment of type 2 diabetes mellitus. Treatments in Endocrinology. 1, 71-78 (2002) 
    8. Kalia, M.: Neurobiological basis of depression: an update. Metabolism. 54, 24-27 (2005) 
    9. Jayanthi, L. D. and Ramamoorthy, S.: Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. The AAPS Journal. 27, 728-738 (2005) 
    10. Rege, N. N., Thatte, U. M. and Dahanukar, S. A.: Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytotherapy Research. 13, 275-291 (1999) 
    11. Reay, J. L., Kennedy, D. O. and Scholey, A. B.: Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J. Psychopharmacol. 20, 771-781 (2006) 
    12. Rausch, W. D., Liu, S., Gille, G . and Radad, K.: Neuroprotective effects of ginsenosides. Acta Neurobiol Exp (Wars). 66, 369-375 (2006) 
    13. Lopez, M. V., Cuadrado, M. P., Ruiz, O. M., Del, A. M. and Accame, M. E.: Neuroprotective effect of individual ginsenosides on astrocytes primary culture. Biochim. Biophys. Acta. 1770, 1308-1316 (2007) 
    14. Wei, X. Y., Yang, J. Y., Wang, J, H. and Wu, C. F.: Anxiolytic effect of saponins from Panax quinquefolium in mice. J. Ethnopharmacol. 111, 613-618 (2007) 
    15. Carr, M. N., Bekku, N. and Yoshimura, H.: Identification of anxiolytic ingredients in ginseng root using the elevated plus-maze test in mice. Eur. J. Pharmacol. 531, 160-165 (2006) 
    16. Nguyen, T. T., Matsumoto, K., Yamasaki, K., Nguyen, M. D., Nguyen, T. N. and Watanabe, H. Effects of majonoside-R2 on pentobarbital sleep and gastric lesion in psychologically stressed mice. Pharmacol. Biochem. Behav. 53, 957-963 (1996) 
    17. Lee, S. P., Honda, K., Rhee, Y. H. and Inoue, S.: Chronic intake of panax ginseng extract stabilizes sleep and wakefulness in food-deprived rats. Neurosci. Lett. 111, 217-221 (1990) 
    18. Kim, H. S., Kang, J. G. and Oh KW.: Inhibition by ginseng total saponin of the development of morphine reverse tolerance and dopamine receptor supersensitivity in mice. Gen. Pharmacol. 26, 1071-1076 (1995) 
    19. Kim, H. S., Kang, J. G., Seong, Y. H., Nam, K. Y. and Oh, K. W.: Blockade by ginseng total saponin of the development of cocaine induced reverse tolerance and dopamine receptor supersensitivity in mice. Pharmacol. Biochem. Behav. 50, 23-27 (1995) 
    20. Kim, H. S., Jang, C. G., Park, W. K., Oh, K. W., Rheu, H. M., Cho, D. H. and Oh, S.: Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice. Gen. Pharmacol. 27, 199-204 (1996) 
    21. Bu, Y., Jin, Z. H., Park, S. Y., Baek, S., Rho, S., Ha, N., Park, S. K., Kim, H. and Sun, Y. K.: Siberian ginseng reduces infarct volume in transient focal cerebral ischemia in Sprague-Dawley rats. Phytotherapy Research. 19, 167-169 (2005) 
    22. Choi, S. S., Lee, J. K. and Suh, H. W.: Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse. Biol. Pharm. Bull. 26, 858-861 (2003) 
    23. Banerjee, U. and Izquierdo, J. A.: Antistress and antifatigue properties of Panax ginseng: comparison with piracetam. Acta Physiological Latino Americana. 32, 277-285 (1982) 
    24. Fulder, S.: Ginseng and the hypothalamic-pituitary control of stress, Am. J. Chin. Med. 9, 112?118 (1981) 
    25. Hiai, S., Yokoyama, H. and Oura, H.: Features of ginseng saponin-induced corticosterone secretion, Endocrinol. Jpn. 26, 737-740 (1979) 
    26. Hiai, S. Yokoyama, H. Oura, H. and Kawashima, Y.: Evaluation of corticosterone secretion-inducing activities of ginsenosides and their prosapogenins and sapogenins. Chem. Pharm. Bull. 31, 168-174 (1983) 
    27. Hiai, S. Yokoyama, H. Oura, H. and Yano, S.: Stimulation of pituitary adrenocortical system by ginseng saponin. Endocrinol. Jpn. 26, 661-665 (1979) 
    28. Thakore, J. and Dinan, T.: Cortisol synthesis inhibition: a new treatment strategy for the clinical and endocrine manifestations of depression. Biol. Psychiatry 37, 364-368 (1995) 
    29. Kim, D. H., Jung, J. S., Suh, H. W., Huh, S. O., Min, S. K., Son, B. K., Park, J. H., Kim, N. D., Kim, Y. H. and Song, D. K.: Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: Involvement of nitric oxide. NeuroReport. 9, 2261-2264 (1998) 
    30. Kima, D. H., Moonb, Y. S., Jungc, J. S., Mind, S. K., Sona, B. K., Suhc, H. W. and Song, D. K.: Effects of ginseng saponin administered intraperitoneally on the hypothalamo-pituitary-adrenal axis in mice. Neurosci. Letters. 343, 62-66 (2003) 
    31. Tatum, A. L. and Seevers, M. H. Experimental cocaine addiction. J. Pharmacol. Exp. Ther. 36, 401-410 (1929) 
    32. Kim, H. S., Kim, K. S. and Oh, K. W.: Inhibition by MK-801 of cocaine-induced sensitization, conditioned place preference, and dopamine-receptor supersensitivity in mice. Brain Res. Bull. 40, 201-207 (1996) 
    33. Kim, H. S., Jang, C. G., Oh, K. W., Oh, S., Rheu, H. M., Rhee, G. S., Seong, Y. H. and Park, W. K.: Effects of ginseng total saponin on morphine-induced hyperactivity and conditioned place preference in mice. J. Ethnopharmacol. 60, 33-42 (1998) 
    34. Kim, H. S., Kim, K. S. and Oh, K. W.: Inhibition by ginsenosides $Rb_1\;and\;Rg_1$ of cocaine-induced hyperactivity, conditioned place preference, and postsynaptic dopamine receptor supersensitivity in mice. Pharmacol. Biochem. Behav. 63, 407-412 (1999) 
    35. Verkhratsky, A. and Kirchhoff, F.: NMDA Receptors in glia. Neuroscientist. 13, 28-37 (2007) 
    36. Gardoni, F. and Di, L. M.: New targets for pharmacological intervention in the glutamatergic synapse. Eur. J. Pharmacol. 545, 2-10 (2006) 
    37. Fan, M. M. and Raymond, L. A.: N-Methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease. Prog. in Neurobiol. 81, 272-293 (2007) 
    38. Bano, D. and Nicotera, P.: $Ca^{2+}$ signals and neuronal death in brain ischemia. Stroke. 38, 674-676 (2007) 
    39. Hsu, S. S., Huang, C. J., Cheng, H. H., Chou, C. T., Lee, H. Y., Wang, J. L., Chen, I. S., Liu, S. I., Lu, Y. C., Chang, H. T., Huang, J. K., Chen, J. S. and Jan, C. R.: Anandamide-induced $Ca^{2+}$ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. Toxicology. 231, 21-29 (2007) 
    40. Zhang, L., Rzigalinski, B. A., Ellis, E. F. and Satin, L. S.: Reduction of voltage-dependent $Mg^{2+}$ blockade of NMDA current in mechanically injured neurons. Science. 274, 1921-1923 (1996) 
    41. Jiang, K. Y. and Qian, Z. N.: Effects of Panax notoginseng saponins on posthypoxic cell damage of neurons in vitro. Acta Pharmacologica Sinica. 16, 399-402 (1995) 
    42. Lim, J. H., Wen, T. C., Matsuda, S., Tanaka, J., Maeda, N., Peng, H., Aburaya, J., Ishihara, K. and Sakanaka, M.: Protection of ischaemic hippocampal neurons by ginsenoside $Rb_1$, a main ingredient of ginseng root. Neurosci. Res. 28, 191-200 (1997) 
    43. Deng, H. and Zhang, J.: Anti-lipid peroxidative effect of ginsenosides $Rb_1\;and\;Rg_1$. Chin. Med. J. 104, 395-398 (1991) 
    44. Kim, H. M., Lee, J. H., Goo, Y. S. and Nah, S. Y.: Effect of ginsenosides on calcium channels and membrane capacitance in rat adrenal chromaffin cells. Brain Res. Bull. 46, 245-251 (1998) 
    45. Lee, J. H., Kim, S. R., Bae, C. S., Kim, D., Hong, H. N. and Nah, S. Y.: Protective effect of ginsenosides, active ingredients of panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus. Neurosci. Lett. 325, 129-133 (2002) 
    46. Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R. and Komatsu, K.: Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK?N?SH cells. Jpn. J. Pharmacol. 99, 254-262 (2002) 
    47. Zhao, R. and McDaniel, W. F.: Ginseng improves strategic learning by normal and brain-damaged rats. NeuroReport. 9, 1619-1624 (1998) 
    48. Chang, M. S., Lee, S. C. and Rho, H. M.: Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Phytother. Res. 13, 641-644 (1999) 
    49. Bormann, J. and Feigenspan, A.: $GABA_C$ receptors. Trends in Nneurosci. 18, 515-519 (1995) 
    50. Turner, A. J. and Whittle, S. R.: Biochemical dissection of the gamma-aminobutyrate synapse. Biochem. Journal. 209, 29-41 (1983) 
    51. Fritschy, J. M. and Panzanelli, P.: Molecular and synaptic organization of GABAA receptors in the cerebellum: Effects of targeted subunit gene deletions. Cerebellum. 5, 275-285 (2006) 
    52. Johnston, G. A. R.: $GABA_C$ receptors: relatively simple transmitter-gated ion channels? Trends in Pharmacol. Sci. 17, 319-323 (1996) 
    53. Bao, H. Y., Zhang, J., Yeo, S. J., Myung, C. S., Kim, H. M., Kim, J. M., Park, J. H., Cho, J. and Kang, J. S.: Memory enhancing and neuroprotective effects of selected ginsenosides. Arch. Pharm. Res. 28, 335-342 (2005)     
    54. Bahrke, M. S. and Morgan, W. R.: Evaluation of the ergogenic properties of ginseng: an update. Sports Medicine. 29, 113-133 (2000) 
    55. Jang, S., Ryu, J. H., Kim, D. H. and Oh, S.: Changes of [3H]MK-801, [3H]muscimol and [$^3H$]flunitrazepam binding in rat brain by the prolonged ventricular infusion of transformed ginsenosides. Neurochem. Res. 29, 2257-2266 (2004) 
    56. Mahmood, T. and Silverstone, T.: Serotonin and bipolar disorder. J. Affect. Disord. 66, 1-11 (2001) 
    57. Shastry, B. S.: Bipolar disorder: An update. Neurochem. Int. 46, 273-279 (2005) 
    58. Saxena, P., Sitholey, A. K., Saxena, S., Vrat, S., Kumar. and Shanker, K.: Platelet serotonin in juvenile mania. Biogenic Amines. 15, 413-421 (1999) 
    59. Pandey, G. N., Pandey, S. C., Ren, X., Dwivedi, Y. and Janicak, P. G.: Serotonin receptors in platelets of bipolar and schizoaffective patients: effect of lithium treatment. Pyschopharmacology. 170, 115-123 (2003) 
    60. Pivac, N., Kozaric, D., Mustapic, M., Dezeljin, M., Borovecki, A., Grubisic, M. and Muck, D.: Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms. J Affect Disord. 93, 223-227 (2006) 
    61. Plain, H. and Berk, M.: The platelet as a peripheral marker in psychiatric illness. Hum. Psychopharmacol. Clin. Exp. 16, 229-236 (2001) 
    62. Peirson, A. R., Heuchert, J. W., Thomala, L., Berk, M., Plein, H. and Cloninger, C. R.: Relationship between serotonin and the temperament and character inventory. Psychiatry Res. 89, 29-37 (1999) 
    63. Muck, M., Jakovljevic. and Pivac, N.: Platelet 5-HT concentrations and suicidal behavior in recurrent major depression. J. Affect. Disord. 39, 73-80 (1996) 
    64. Meszaros, Z., Borsiczky, D., Mate, M., Tarcali, J., Szombathy, T., Tekes, K. and Magyar, K.: Platelet MAO-B activity and serotonin content in patients with dementia: effect of age, medication and disease. Neurochem. Res. 23, 863-868 (1998) 
    65. Goveas, J. S., Csernansky, J. G. and Coccaro, E. F.: Platelet serotonin content correlates inversely with life history of aggression in personality-disordered subjects. Psychiatry Res. 126, 23-32 (2004) 
    66. Pivac, N., Muck, D. and Jakovljevic, M.: Platelet 5-HT levels and hypothalamic?pituitary?adrenal axis activity in schizophrenic patients with positive and negative symptoms. Neuropsychobiology. 36, 19-21 (1997) 
    67. Muck, D., Jakovljevic, M. and Deanovic, Z.: Platelet serotonin in subtypes of schizophrenia and unipolar depression. Psychiatry Res. 38, 105-113 (1991) 
    68. Praag, H. M.: The cognitive paradox in posttraumatic stress disorder: a hypothesis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 28, 923-935 (2004) 
    69. Southwick, S. M., Krystal, J. H., Bremner, D., Morgan, C. A., Nicolaou, A. L., Nagy, L. M., Johnson, D. R., Heninger, G. R. and Charney, D. S.: Noradrenergic and serotonergic function in posttraumatic stress disorder. Arch. Gen. Psychiatry. 54, 749-758 (1997) 
    70. Bhattcharyya, D. and Sur, T. K.: Effect of Panax ginseng and diazepam on brain 5-hydroxytryptamine and its modification by diclofenac in rat. Indian J. Physiol. Pharmacol. 43, 505-509 (1999) 
    71. Sheikh, N., Ahmad, A., Siripurapu, K. B., Kuchibhotla, V. K., Singh, S. and Palit, G.: Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. J. of Ethnopharmacol. 111, 671-676 (2007) 
    72. Min, Y. K., Chung, S. H., Lee, J. S., Kim, S. S., Shin, H. D., Lim, B. V., Shin, M. C., Jang, M. H., Kim, E. H. and Kim, C. J.: Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats. J. of Pharmacol Sci. 93, 218-221 (2003) 
    73. Choi, S., Lee, J. H., Oh, S., Rhim, H., Lee, S. M. and Nah, S. Y.: Effects of ginsenoside $Rg_2$ on the $5-HT_{3A}$ receptor-mediated ion current in Xenopus oocytes. Molecules and Cells. 15, 108-113 (2003) 
    74. Lee, B. H., Lee, J. H., Lee, S. M., Jeong, S. M., Yoon, I. S., Lee, J. H., Choi, S. H., Pyo, M. K., Rhim, H., Kim, H. C., Jang, C. G., Lee, B. C., Park, C. S. and Nah, S. Y.: Identification of ginsenoside interaction sites in $5-HT_{3A}$ receptors. Neuropharmacol. 52, 1139-1150 (2007) 
    75. Neveu, P. J., Delrue, C., Deleplanque, B. D., Amato, F. R., Puglisi, A. S. and Cabib, S.: Influence of brain and behavioral lateralization in brain: Monoaminergic, neuroendocrine and immune stress responses. Annals of the New York Academy of Sciences. 741, 271-282 (1994) 
    76. Kennedy, D. O., Scholey, A. B., Drewery, L., Marsh, V. R., Moore, B. and Ashton, H.: Electroencephalograph effects of single doses of Ginkgo biloba and Panax ginseng in healthy young volunteers. Pharmacol. Biochem. Behav. 75, 701-709 (2003) 
    77. Kim, H. S., Oh, K. W., Rheu, H. M. and Kim, S. H.: Antagonism of U-50,488H-induced antinociception by ginseng total saponins is dependent on serotonergic mechanisms. Pharmacol. Biochem. Behav. 42, 587-593 (1992) 
    78. Yuan, C. S., Attele, A. S., Wu, J. A. and Liu, D.: Modulation of American ginseng on brainstem GABAergic effects in rats. J. Ethnopharmacol. 62, 215-222 (1998) 
    79. Liao, B., Newmark, H. and Zhou, R.: Neuroprotective effect of ginseng total saponin and ginsenosides $Rb_1\;and\;Rg_1$ on spinal cord neurons in vitro. Exp. Neurol. 173, 224-234 (2002) 
    80. Pivac, N., Muck, D., Jakovljevic, M. and Brzovic, Z.: Hypothalamic?pituitary?adrenal axis function and platelet serotonin concentrations in depressed patients. Psychiatry Res. 73, 123-132 (1997) 
    81. Murphy, B. Filipini, D. and Ghadirian, A.: Possible use of glucocorticoid receptor antagonists in the treatment of major depression: Preliminary results using RU 486. J. Psychiatry Neurosci. 18, 209-213 (1993) 
    82. Brady, K., Pearlstein, T., Asnis, G. M., Baker, D., Rothbaum, B., Sikes, C. R. and Farfel, G. M.: Efficacy and safety of sertraline treatment of posttraumatic stress disorder. JAMA. 283, 1837-1844 (2000) 
    83. Phillips, L. J., Francey, S. M., Edwards, J. and McMurray, N.: Stress and psychosis: towards the development of new models of investigation. Clinical Psychology Review. 27, 307-317 (2007) 
    84. Bhattacharya, S. K. and Murugandam, A. V.: Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol. Biochem. Behav. 75, 547-555 (2003) 
    85. Cha, H. Y., Park, J. H., Hong, J. T., Yoo, H. S., Song, S., Hwang, B. Y., Eun, J. S. and Oh, K. W.: Anxiolytic-like effects of ginsenosides on the elevated plus-maze model in mice. Biol. Pharm. Bull. 28, 1621-1625 (2005) 
    86. Kim, H. S. and Kim, K. S.: Inhibitory effects of ginseng total saponin on nicotine-induced hyperactivity, reverse tolerance and dopamine receptor supersensitivity. Behav. Brain Research. 103, 55-61 (1999) 
    87. Herman, J. and Cullinan, W.: Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 20, 78-84 (1997) 
    88. Kim, H. S., Kim, K. S. and Oh, K. W.: Ginseng total saponin inhibits nicotine-induced hyperactivity and conditioned place preference in mice. J. Ethnopharmacol. 66, 83-90 (1999) 
    89. Yang, P. M., Chen, H. C., Tsai, J. S. and Lin, L. Y.: Cadmium induces $Ca^{2+}$-dependent necrotic cell death through calpain-triggered mitochondrial depolarization and reactive oxygen species-mediated inhibition of nuclear factor-kappaB activity. Chem. Res. Toxicol. 20, 406-415 (2007) 
    90. Hori, N. and Carpenter, D. O.: Transient ischemia causes a reduction of $Mg^{2+}$ blockade of NMDA receptors. Neurosci. Lett. 173, 75-78 (1994) 
    91. Nishiyama, N., Cho, S. T., Kitagama, I. and Saito, H.: Malonylginsenoside $Rb_1$ potentiates nerve growth factor (NGF)-induced neurite outgrowth of cultured chick embryonic dorsal root ganglia. Biol. Pharm. Bull. 17, 509-513 (1994) 
    92. Kim, H. S., Hwang, S. L., Nah, S. Y. and Oh, S.: Changes of [$^3H$]MK-801, [$^3H$]muscimol and [$^3H$]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and $Rg_1$. Pharmacol. Res.. 43, 473-479 (2001) 
    93. Muck-Seler, D., Pivac, N., Jakovljevic, M., Sagud, M. and Mihaljevic, A.: Platelet 5-HT concentration and comorbid depression in war veterans with or without posttraumatic stress disorder. J. Affect. Disord. 75, 171-179 (2003) 
    94. Lee, B. H., Jeong, S. M., Lee, J. H., Kim, D. H., Kim, J. H., Kim, J. I., Shin, H. C., Lee, S. M. and Nah, S. Y.: Differential effect of ginsenoside metabolites on the $5-HT_{3A}$ receptor-mediated ion current in Xenopus oocytes. Molecules and Cells. 17, 51-56 (2004) 
    95. Park, J. H., Cha, H. Y., Seo, J. J., Hong, J. T., Han, K. and Oh, K. W.: Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Prog. Neuropsychopharmacol Biol. Psychiatry. 29, 895-900 (2005) 
    96. Geller, S. E. and Studee, L.: Botanical and dietary supplements for mood and anxiety in menopausal women. Menopause. 14, 541-549 (2007) 
    97. Wen, T. C., Yoshimura, H., Matsuda, S., Lim, J. H. and Sakanaka, M.: Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischaemia. Acta Neuropathol. 91, 15-22 (1996) 
    98. Zhong, Y. M., Nishijo, H., Uwano, T., Tamura, R., Kawanishi, K. and Ono, T.: Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats. Physiol. Behav. 69, 511-525 (2000) 
    99. Shiah, I. S. and Yatham, L. N.: Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies. Bipolar Disord. 2, 77-92 (2000) 
    100. Nguyen, T. T., Matsumoto, K., Yamasaki, K. and Watanabe, H.: Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids. Life Sci. 61, 395-402 (1997) 
    101. Kim, H. S., Hong, Y. T., Oh, K. W., Seong, Y. H., Rheu, H. M., Cho, D. H., Oh, S., Park, W. K. and Jang, C. G.: Inhibition by ginsenosides $Rb_1\;and\;Rg_1$ of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice. Gen. Pharmacol. 30, 783-789 (1998) 
    102. Askenazy, F., Caci, H., Myquel, M., Darcourt, G. and Lecrubier, Y.: Relationship between impulsivity and platelet serotonin content in adolescents. Psychiatry Res. 94, 19-28 (2000) 
    103. Yun, Y. J., Lee, B., Hahm, D. H., Kang, S. K., Han, S. M., Lee, H. J., Pyun, K. H. and Shim, I.: Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. Biol. Pharm. Bull. 30, 337-342 (2007) 
  • 이 논문을 인용한 문헌 (3)

    1. 2009. "" Journal of ginseng research = 高麗人參學會誌, 33(4): 305~310     
    2. Lee, Beom-Joon ; Kim, Jung-Woo ; Ji, Eun-Young ; Yun, Seung-Youn ; Lee, Sang-Myung ; Lew, Jae-Hwan 2009. "Anxiolytic and Antidepressive Effect of Non-saponin Fraction of Korean Red Ginseng" 大韓本草學會誌 = The Korea journal of herbology, 24(4): 143~148     
    3. 2010. "" Journal of ginseng research = 高麗人參學會誌, 34(1): 30~40     

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