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생명과학회지 = Journal of life science v.18 no.2 = no.94, 2008년, pp.249 - 254   피인용횟수: 6

다시마 추출물이 난소를 절제한 흰 쥐의 혈 중 지질 함량에 미치는 영향
The Effect of Sea Tangle Extract on Serum Lipid Level in Ovariectomized Rats

이영애   (신라대학교 의생명과학대학 식품영양학과UU0000867  ); 김미향   (신라대학교 의생명과학대학 식품영양학과UU0000867  );
  • 초록

    폐경 후 여성의 비만은 독특한 생리적 현상으로 음식물 섭취가 촉진되고, 몸무게와 지방조직이 증가되고, 정상 여성보다 혈류 관련 질환 발병이 높아지는 것으로 알려져 있다. 이에 본 연구에서는 갱년기를 유도한 흰쥐에 다시마 추출물을 투여하여 체내 지질 함량 변화에 대해 그 효과를 검토하였다. 그 결과 난소를 절제한 OVX-control군이 난소를 절제하지 않은 Sham군보다 체중이 뚜렷이 증가하는 경향을 보였으며, 다시마 추출물이 체중감소에는 크게 영향을 미치지 않았다. GOT 활성에서는 난소를 절제한 OVX-control군이 난소를 절제하지 않은 Sham군에 비해 GOT 활성이 증가하였으나, 난소를 절제한 후 다시마 추출물 투여에 의해 난소를 절제하지 않은 Sham군보다 GOT활성이 더 감소하는 결과가 나타났다. GPT 활성에서는 난소를 절제 한 후 다시마 추출물을 투여한 군에서는 OVX-control군에 비해 감소하는 경향을 보였는데, 특히 OVX-ST200군에서 감소하는 결과가 나타났다. 난소 절제 후 다시마 추출물 투여는 난소 절제로 인해 야기되는 혈중 총 콜레스테롤의 함량 및 혈청 지질 농도의 증가를 감소시켰다. 또한, HDL-콜레스테롤은 난소절제 군에 비해 난소절제 후 다시마 추출물을 투여하였을 때 혈중 함량이 증가하였다. 이상의 결과에서 다시마 추출물이 갱년기 장애 시 발생할 수 있는 혈 중 지질 함량 변화에 효과가 있는 것으로 나타나 혈류 관련 질환에 대한 개선 식품으로의 활용이 기대된다.


    This study was performed to investigate the effects of sea tangle (ST) extracts on serum lipid concentration in ovariectomized rats. Weight-matched female Sprague-Dawley strain rats were assigned to four groups. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with ST at 50 mg/kg body wt (OVX-ST50) and ovariectomized rats supplemented with ST at 200 mg/kg body wt (OVX-ST200). The activities of serum GOT and GPT were increased by ovariectomized. The serum GOT levels in OVX-ST50 and OVX-ST200 groups were decreased than OVX-control group. But GPT level was only decreased in the serum of OVX-ST200 group. Serum total cholesterol and triglyceride contents decreased in sham group compared with OVX-control group by ovariectomy. Six weeks feeding of ST extract resulted in a significant lowering of serum triglyceride and lowering tendency of total cholesterol Level. The serum HDL-cholesterol was higher in ST groups than OVX-control group. These results suggest that the beneficial effect of ST extract may be used to possibly improve on the lipid metabolic syndrome of menopausal women.


  • 주제어

    Sea tangle .   ovariectomized rat .   lipid metabolism .   postmenopausal.  

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    1. Lee, Dong-Soo ; Shin, Myung-Kyo ; Pyeun, Jae-Hyeung ; Lee, Jin-Woo 2009. "A Simple Method for Isolation of Polymannuronate and Polyguluronate from Alginate Hydrolyzed by Organic Acids" 생명과학회지 = Journal of life science, 19(1): 34~39     
    2. Jang, Yu-Jung ; Kwon, Sang-Oh ; Yeo, Kyung-Mok ; Hong, Mi-Jung ; Kim, Bok-Nam ; Han, Dae-Seok 2011. "Anti-obesity Effect of Sargassum confusum Ethanol Extract in Obese Rats" 한국식품과학회지 = Korean journal of food science and technology, 43(2): 189~194     
    3. Park, Se-Jin ; Jeon, You-Jin ; Kim, Hak-Ju ; Han, Ji-Sook 2013. "Anti-obesity Effects of Ishige okamurae Extract in C57BL/6J mice Fed High-fat Diet" 한국식품과학회지 = Korean journal of food science and technology, 45(2): 199~205     
    4. Park, Sung-Jin ; Lee, In-Seon ; Lee, Sam-Pin ; Yu, Mi-Hee 2013. "Inhibition of Adipocyte Differentiation and Adipogenesis by Supercritical Fluid Extracts and Marc from Cinnamomum verum" 생명과학회지 = Journal of life science, 23(4): 510~517     
    5. Park, Young Mi ; Oh, Hong Geun ; Kang, Yang Gyu ; Kim, Young Pill ; Sin, Hong Sig ; Jang, Seung Hwan ; Kim, Hee Jeong ; Lee, Sang Wang ; Lee, Hak Yong 2015. "Anti-Obesity Effects of Lactic Acid Bacteria-Fermented Dioscoreae Rhizoma Powder on High Fat Diet-Fed Animal Model" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 29(3): 267~272     
    6. Lee, Juyeong ; Kim, Bokyung ; Park, Mi-Hwa ; Choi, Kyung-Ha ; Kong, Changsuk ; Lee, Sang-Hyeon ; Kim, Yuck Yong ; Yu, Ki Hwan ; Kim, Mihyang 2016. "Effects of Colpomenia sinuosa Extract on Serum Lipid Level and Bone Formation in Ovariectomized Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 45(4): 492~500     

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