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韓國營養學會誌 = The Korean journal of nutrition. v.41 no.1, 2008년, pp.5 - 12   피인용횟수: 8

고지방식이 급여 흰쥐에서 대황 및 대황정제환의 혈청 지질 개선 효과
Effect of Eisenia Bicyclis and Its Pill on Serum Lipid Status in Rats Fed High Fat Diet

장연희   (대구가톨릭대학교 식품영양학과UU0000343  ); 최상원   (대구가톨릭대학교 식품영양학과UU0000343  ); 조성희   (대구가톨릭대학교 식품영양학과UU0000343  );
  • 초록

    In order to investigate whether Eisenia bicyclis (EB) as a functional food material improves serum lipid status, supplementation of EB powder or EB extract to the high fat/cholesterol diet was tested in 6-week old male Sprague-Dawley rats for four weeks. In the first experiment, four kinds of seaweed powder -Eisenia bicyclis (EB), Undaria pinnatifida (Up), Laminaria japonica (LJ), and Ecklonia stolonifera (ES) were compared with alginic acid (ALG) as well as control. In the second experiment, EB water extract and EB ethanol extract and EB pill containing EB and LJ powder were compared with the EB powder. Amounts of dietary fiber contained in experimental diets were adjusted to provide 5% of diets. Serum total cholesterol was significantly lower only in rats fed LJ or EB powder, but HDL cholesterol was higher in rats fed UP, LJ, ES or EB powder. Ratios of HDL-/total cholesterol of all seaweed groups including ALG were significantly higher than that of the control group. Serum triglyceride was lower in LJ, EB nd ES powder groups than the control group. In comparison of EB extracts, triglyceride level was decreased in rats fed only EB water extract as compared to control rats, but HDL cholesterol was elevated with both water and ethanol extracts. Serum levels of total cholesterol, triglyceride were decreased and HDL cholesterol was increased by the EB pill. Serum levels of thiobarbituric acid-reactive substances were lower in rats fed ES powder, and EB powder, EB water extract or EB pill, as compared to the control rats. Supplementation of EB powder and EB pill reduced serum level of GOT and GPT, respectively, as compared to the control group. In conclusion, EB and EB pill improve serum lipid status and may be utilized as ingredient of functional foods for the purpose of improving serum lipid profile and inhibiting peroxidation of lipids.


  • 주제어

    Eisenia bicyclis (EB) .   seaweed .   EB pill .   high fat/cholesterol diet .   serum lipid .   TBARS.  

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  • 이 논문을 인용한 문헌 (8)

    1. Cho, Sung-Hee ; Park, So-Young ; Choi, Sang-Won 2008. "Effects of Eisenia Bicyclis Extracts and Pill on Blood Glucose and Lipid Profile in Streptozotocin-Induced Diabetic Mice" 韓國營養學會誌 = The Korean journal of nutrition., 41(6): 493~501     
    2. Park, Hyun-Suk ; Yang, Kyung-Chun ; Yang, Kyung-Mi 2009. "The Effects of Medicinal Herb-made Sikhe on Damage and Lipid Levels of Liver in Rats Fed High-cholesterol Diets" 생명과학회지 = Journal of life science, 19(8): 1104~1111     
    3. Lee, Jung-Sun ; Lee, Myung-Heon ; Koo, Jae-Geun 2010. "Effects of Porphyran and Insoluble Dietary Fiber Isolated from Laver, Porphyra yezoensis, on Lipid Metabolism in Rats Fed High Fat Diet" 한국식품영양학회지 = The Korean journal of food and nutrition, 23(4): 562~569     
    4. Kim, Hyung-Jin ; Choi, Sang-Won ; Cho, Sung-Hee 2010. "Effects of Various Mulberry Products on the Blood Glucose and Lipid Status of Streptozotocin-induced Diabetic Rats" 韓國營養學會誌 = The Korean journal of nutrition., 43(6): 551~560     
    5. Jeun, Dong-Joo ; Cha, Yun-Yeop ; Lee, Eun 2011. "Inflammatory Effect of Rheum undulatum L." 韓方再活醫學科學會誌 = Journal of oriental rehabilitation medicine, 21(1): 35~46   
    6. Park, Yong Soo ; Kang, Min Suk ; Kim, Bo Kyung ; Kim, Mihyang 2013. "The Effect of Eisenia bicyclis Extracts on Bone Tissues in Ovariectomized Rats" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 42(1): 33~39     
    7. Han, Hae-Na ; Eom, Sung-Hwan ; Kim, Ji-Hoon ; Kim, Deok-Hoon ; Kim, Song-Hee ; Kim, Yunhye ; Yeom, Seung-Mok ; Kim, Young-Mog 2015. "Effects of Lactic Acid Bacterial Fermentation on the Antioxidant and Anti-inflammatory Activity of Brown Algae Eisenia bicyclis Extract" 한국수산과학회지 = Korean journal of fisheries and aquatic sciences, 48(2): 151~157     
    8. Bae, Gui-Jeong ; Ha, Bae-Jin 2016. "Effects of Cladosiphon okamuranus on Lipid Metabolism in High-fat-diet Rats" 생명과학회지 = Journal of life science, 26(6): 657~662     

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