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Enhancement of Immune-Potentiation of Cichorium endivia L. by Ultrasonification Extraction Process

권민철   (강원대학교 BT특성화학부(대학)UU0000037  ); 한재건   (강원대학교 BT특성화학부(대학)UU0000037  ); Qadir, Syed Abdul    (강원대학교 BT특성화학부(대학)   ); 안주희   (강원대학교 BT특성화학부(대학)UU0000037  ); 이달호   (설악전통식품CC0099634  ); 이현용   (강원대학교 생명공학연구소UU0000037  );
  • 초록

    Immune-potentiation of Chicorium endivia L. were investigated on follows extracts associated with ultrasonification process at 60 kHz and showed the highest promotion of human B and T cell growth, about $10{\sim}20%$ compared to the control. The secretion of TNF- ${\alpha}$ and IL-6 was also enhanced by the addition $(0.5mg/m{\ell})$ of the extracts. NK cell activation was Improved up to 1.37 times higher than the control, through adding extracts. It was also found that extracts from C. endivia L. could yield higher nitric oxide production from macrophage than Lipopolysaccaharides (LPS). It can be concluded that, in general, the extracts treated with ultrasonification has higher immune activity than others, possibly by higher yielding immune-modulatory activity than conventional extraction process. The optimum condition for the extraction of C. endivia L. is ethanol extraction at $60{\sim}100^{\circ}C$ associated with ultrasonification.


  • 주제어

    Chicorium endivia L.   .   Immune-Potentiation .   Ultrasonification.  

  • 참고문헌 (17)

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    2. Ha, Ji-Hye ; Han, Jae-Gun ; Jeong, Hyang-Suk ; Oh, Sung-Ho ; Kwon, Min-Chul ; Choi, Young-Beom ; Ko, Jung-Rim ; Lee, Hyeon-Yong 2008. "Enhancement of Immune Activities of Natural Water-Soluble Sulforaphane by Nano Encapsulation Process" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 16(6): 402~408     
    3. Kwon, Min-Chul ; Han, Jae-Gun ; Ha, Ji-Hye ; Jin, Ling ; Choi, Geun-Pyo ; Park, Uk-Yeon ; Lee, Dal-Ho ; Hyeon-Yong, Lee 2008. "Extension of Storage Time of Chicon using Nanoparticle of Machilus thunbergii Extracts" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 16(5): 320~325     
    4. Yun, Jun-Yong ; Choi, Se-Yong ; Park, Pyo-Jam ; Chung, Hae-Gon ; Shin, Heung-Mook ; Suk, Kyoung-Ho ; Lim, Beong-Ou 2008. "Extracts of Artemisia princeps Pampanini Inhibit Lipopolysaccharide-induced Nitric Oxide, Cyclooxygenase-2, Prostaglandin $E_2$, and Tumor Necrosis Factor-$\alpha$ Production from Murine Macrophage RAW 264.7 Cells" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 16(5): 326~331     
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    6. Lee, Kwang-Jae ; Yun, In-Ju ; Kim, Hee-Yeon ; Kim, Kyung-Hee ; Kim, Young-Jin ; Kim, Dong-Woon ; Lim, Sang-Hyun 2010. "Antioxidative Activity of Solvent Extracts from Synurus excelsus and Synurus palmatopinnatifidus" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 39(12): 1893~1897     
    7. Lee, Kwang-Jae ; Park, Min-Hee ; Park, Yu-Hwa ; Lim, Sang-Hyun ; Kim, Kyung-Hee ; Kim, Young-Guk ; Ahn, Young-Sup ; Kim, Hee-Yeon 2011. "Antioxidant Activity and Nitric Oxide Production of Ethanol Extracts from Astragali membranaceus Bunge and A. membranaceus Bunge var mongholicus Hisiao" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(12): 1793~1796     
    8. Ling, Jin ; Ha, Ji-Hye ; Choi, Yoon-Yong ; Seo, Yong-Chang ; Kim, Ji-Seon ; Kim, Young-Ock ; Cha, Seon-Woo ; Kim, Jin-Chul ; Lee, Hyeon-Yong 2011. "Enhancement of Cosmeceutical Activities of Berberis koreana Bark by High Pressure and Ultrasonification Extraction Processes" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 19(1): 54~65     
    9. Kang, Hyun Woo 2012. "Antioxidative Activity of Extracts from Cichorium endivia L." 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 41(11): 1487~1492     
    10. Seo, Yong Chang ; Kim, Ji Seon ; Kim, Young Ock ; Kim, Jin Chul ; Lee, Hyeon Yong 2013. "Immune Activity of Lithospermum erythrorhizon Extracted by Extreme Low Temperature Extraction Process" 韓國藥用作物學會誌 = Korean journal of medicinal crop science, 21(2): 105~111     
    11. Kwon, Hye-Jeong ; Jeong, Eun-Kyoung ; Jeong, Hye-Jeong ; Kim, Si-Chang ; Heo, Nam-Kee ; No, Hee-Sun 2015. "Proximate Compositions and Biological Activities of Lactuca indica L. Seonhyang and Wild Species Depending on Harvesting Time" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 44(3): 363~369     

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