본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Effect of Cigarette Smoke Exposure Against Oxidative Damage in Scrapie-infected Mice

Sohn, Hyung-Ok    (KT&G Central Research Institute   ); Moon, Ja-Young    (Department of Biochemistry and Health Sciences, College of Natural Sciences, Changwon National University   ); Lim, Heung-Bin    (Department of Industrial Plant Science & Technology, College of Agriculture, Chungbuk National University   ); Lee, Dong-Wook    (Natural Resources Research Institute  );
  • 초록

    Although prion diseases, a group of fatal neurodegenerative diseases of human and animals, are presumed to be caused by several mechanisms including abnormal change of prion protein, oxidative stress is still believed to play a central role in development of the diseases. Cigarette smoking has a few beneficial effects on neuronal diseases such as Alzheimer's disease and Parkinson's disease despite of many detrimental effects. In this study, we investigated how chronic cigarette smoking could exert such beneficial effect against oxidative damage. For this study, homogenates of 87V scrapie-infected brain was inoculated on intracerebral system of IM mice through stereotaxic microinjection and biochemical properties concerning with oxidative stress were examined. The scrapie infection decreased the activity of mitochondrial Mn-containing superoxide dismutase by 50% of the control, meanwhile the effects on other antioxidant enzymes including Cu or Zn-containing superoxide dismutase were not significant. Additionally, the infection elevated superoxide level as well as monoamine oxide-B (MAO-B) in the infected brain. Interestingly, many of the detrimental effects were improved in partial or significantly by long-term cigarette smoke exposure (CSE). CSE not only completely prevented the generation of mitochondrial superoxide but also significantly (p

  • 주제어

    Prion disease .   neurodegeneration .   oxidative stress .   cigarette smoke exposure.  

  • 참고문헌 (26)

    1. Esterbauer, H., Lang, J., Zadravec, S., and Slater, T. F. (1984) Detection of malonaldehyde by high-performance liquid chromatography. Methods Enzymol. 105, 319-28 
    2. Lee, D. W., Sohn, H. O., Lim, H. B., Lee, Y. G., Kim, Y. S., Carp, R. I., and Wisniewski, H. M. (1999) Alteration of free radical metabolism in the brain of mice infected with scrapie agent. Free Radic Res. 30(6), 499-507 
    3. Milhavet, O., McMahon, H. E., Rachidi, W., Nishida, N., Katamine, S., Mange, A., Arlotto, M., Casanova, D., Riondel, J., Favier, A., and Lehmann, S. (2000) Prion infection impairs the cellular response to oxidative stress. Proc. Natl Acad. Sci. USA. 97, 13937-13942 
    4. Lee, P. N. (1994) Smoking and Alzheimer's disease: A review of the epidemiological evidence. Neuroepidemiol. 13: 131-144 
    5. Grandinetti A., Morens D. M., Reed D. and MacEachern D. (1994) Prospective study of cigarette smoking and the risk of developing idiopathic Parkinson's disease. Am. J. Epidemiol. 139(12): 1129-1138 
    6. Kim, Y. S., Carp, R. I., Callahan, S. M. and Wisniewski, H. M. (1990) Incubation period and histopathological changes in mice infected stereotaxically in different brain areas with the 87V scrapie strain. Acta Neuropathol. 80: 388-392 
    7. Milhavet, O. and Lehmann, S. (2002) Oxidative stress and the prion protein in transmissible spongiform encephalopathies. Brain Res. Rev. 38(3), 328-339 
    8. Habig, W. H., Pabast, M. J., and Jakoby, W. B. (1974) Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139 
    9. Kim, J. I., Choi, S. I., Kim, N. H, Jin, J. K., Choi, E. K, Carp, R. I., and Kim, Y. S. (2001) Oxidative stress and neurodegeneration in prion diseases. Ann N Y Acad Sci. 928, 182-186 
    10. Laganiere, S. and Yu, B. P. (1988) Antilipoperoxidation action of food restriction. Biochem. Biophys. Res. Commun. 145, 1185-1191 
    11. Guentchev, M., Voigtlander, T., Haberler, C., Groschup, M. H., and Budka, H. (2000) Evidence for oxidative stress in experimental prion disease. Neurobiol. Dis. 7, 270-273 
    12. Nohl, H. and Hegner, D. (1978) Do mitochondria produce oxygen radicals in vivo? Eur. J. Biochem. 82, 563-567 
    13. Wong, B. S., Brown, D. R., Pan, T., Whiteman, M., Liu, T., Bu, X., Li, R., Gambetti, P., Olesik, J., Rubenstein, R., Sy, M. S. (2001) Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities. J. Neurochem. 79(3), 689-698 
    14. Lowry, O. H., Rosebrough, H. J., Farr, A. B., and Randall, R. J. (1951) Protein measurement with the folin-phenol reagent. J. Biol. Chem. 193, 265-275 
    15. McCord, J. R., Colby, M. D., and Fridovich, I. (1972) Superoxide dismutase, enzymatic function for erythrocuprein (hemocuprein). J. Biol. Chem. 231, 6049-6055 
    16. Levine, R. L., Garland, D., Oliver, C. N., Amici, A., Climent I., Lenz, A. G.. et al. (1990) Determination of carbonyl content in oxidatively modified proteins. Meth. Enzymol. 186, 464-478 
    17. Morinan, A. and Garratt, H. M. (1985) An improved fluorometric assay for brain monoamine oxidase. J. Pharmacol. Method. 13, 213-223 
    18. Abe, M., Reiter, R. J., Orhii, P. H., Hara, M., Poeggeler, B., and Barrow-Walden, L. R. (1994) Inhibitory effect of melatonin on cataract formation in newborn rats: evidence of an antioxidative role for melatonin. J. Pineal Res. 17, 94-100 
    19. Rajesh, N., Kalaria, R. N., Michell, M. J., and Harik, S. (1987) Correlation of MPTP neurotoxicity with blood-brain barrier monoamine oxidase activity. Proc. Natl. Acad. Sci. USA. 84, 13521-3525 
    20. Sohn, H.O., Hyun, H.C., Shin, H. J., Han, J. H., Park, C. H., Moon, J. Y., Lim, H. B. and Lee, D. W. (2005) Cigarette smoke attenuates histopathological and neurobiological changes caused by 87V scrapie agent infection in IM mice. J. Korean Soc. Tob. Sci. 27(2):212-218     
    21. Wisniewski, H. M., Merz, G.. S. and Carp, R. I. (1984) Senile dementia of the Alzheimer's type : possibility of an infectious ethiologyin genetically susceptible individuals. Acta Neurol. Scand. Suppl. 69:91-99 
    22. Carp, R. I., Callahan, S. M., Sersen, E. A. and Moretz, R. C. (1984) Preclinical changes in weight of scrapie infected mice as a function of scrapie agent-mouse strain combination. Intervirol. 21: 61-69 
    23. Linert, W., Bridge, M. H., Huber, M., Bjugstad, K. B., Grossman,S., and Arendash, G. W. (1997) In vitro and in vivo studies investigating possible antioxidant actions of nicotine: relevance to Parkinson's and Alzheimer's diseases. Biochim. Biophys. Acta.1454(2), 143-152 
    24. Cormier, A., Morin, C., Zini, R., Tillement, J. P., and Lagrue, G. (2003) Nicotine protects rat brain mitochondria against experimental injuries. Neuropharmacology 44(5), 642-652 
    25. Saura, J., Richards, J. G., and Mahy, N. (1994) Age-related changes on MAO in C57BL mouse tissues: a quantitative radioautographic study. J. Neural. Transm. (Suppl) 41, 89-94 
    26. Prusiner, S. B. (1995) The prion disease. Scientific American 272:30-37 

 저자의 다른 논문

  • 문자영 (20)

    1. 1999 "Acetone Enhancement of Cumene Hydroperoxide-supported Microsomal Cytochrome P450-dependent Benzo(a)pyrene Hydroxylation" Journal of biochemistry and molecular biology = 한국생화학회지 32 (3): 226~231    
    2. 2000 "Proteolysis of $\beta$-Catenin in Apoptotic Jurkat Cells" Journal of life science 10 (1): 57~63    
    3. 2000 "Penetration of HEp-2 and Chinese Hamster Ovary Epithelial Cells by Escherichia coli Harbouring the Invasion-Conferring Genomic Region from Salmonella typhimurium" The journal of microbiology 38 (4): 270~274    
    4. 2001 "에탄올 및 사염화탄소의 긴 손상에 미치는 흰점박이꽃무지 추출물의 영향" 생명과학회지 = Journal of life science 11 (5): 405~414    
    5. 2002 "삼백초 추출물의 자궁경부암세포 억제 효능" 약학회지 = Yakhak hoeji 46 (6): 426~432    
    6. 2005 "Cigarette Smoke Attenuates Histopathological and Neurobiological Changes Caused by 87V Scrapie Agent Infection in IM Mice" 한국연초학회지 = Journal of the Korean society of tobacco science 27 (2): 212~218    
    7. 2006 "Regulation of LPS-induced Nitric Oxide Synthase Activity by Cigarette Smoke in Mouse Brain" Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 22 (3): 245~251    
    8. 2006 "부산,경남에서 판매되는 시너(Thinner)의 구성 성분 중 벤젠 등 일부 독성물질의 함량과 물질안전보건자료에 관한 연구" 한국산업위생학회지 = Journal of Korean Society of Occupational and environmental hygiene 16 (4): 314~323    
    9. 2006 "아밀로이드 베타 단백질에 의해 유도된 신경세포 독성에 대한 원추리의 억제 효과 탐색" 大韓韓醫學會誌 = Journal of Korean Oriental Medicine 27 (2): 122~133    
    10. 2007 "Isolation and characterization of Vitreoscilla mutant defective in catalase-peroxidase hydroperoxidase I" 韓國家畜衛生學會誌 = Korean journal of veterinary service 30 (3): 291~304    
  • 임흥빈 (31)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역


  • NDSL :
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기