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대한치과교정학회지 = The Korean journal of orthodontics v.39 no.5, 2009년, pp.337 - 347   SCIE 피인용횟수: 1
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

백서 전상악골 봉합부 확장시 비타민 E에 의한 골형성 촉진
Stimulation of bone formation in the expanding inter-premaxillary suture by vitamin E, in rat

Uysal, Tancan    (Department of Orthodontics, Faculty of Dentistry, Erciyes University   ); Amasyali, Mihri    (Department of Orthodontics, Centre of Dental Sciences, Gulhane Military Medical Academy   ); Olmez, Huseyin    (Department of Orthodontics, Centre of Dental Sciences, Gulhane Military Medical Academy   ); Karslioglu, Yildirim    (Department of Pathology, Faculty of Medicine, Gulhane Military Medical Academy   ); Gunhan, Omer    (Department of Pathology, Faculty of Medicine, Gulhane Military Medical Academy  );
  • 초록

    본 연구는 백서에서 전상악골 봉합부의 확장시 비타민 E( $\alpha$ -토코페롤) 복용의 골형성 효과를 조직계측학적으로 평가하기 위해 시행되었다. 30마리의 50 - 60일된 백서를 6마리씩 5개 집단(대조군과 실험군 4개 집단)으로 분류하였다. 모든 실험 집단에서 50 gm의 힘으로 전상악부를 확장하였다. 장치 장착 1일 후, 대조군(Group I)에는 생리식염수를, 실험군(Group II, Group III, Group IV)에는 $\alpha$ -토코페롤을 각각 2 mg/kg, 10 mg/kg, 50 mg/kg씩 전상악골 봉합부에 주사하였다. 다른 실험군(Group V)에는 장치 장착 3, 6, 9일 후 각각 10 mg/kg씩의 $\alpha$ -토코페롤을 주사하였다. 10일간 유지한 뒤 봉합부에서의 골형성을 조직계측학적 방법으로 평가하였다. Kruskal-Wallis rank 및 Mann-Whitney U test를 사용하여 유의수준 0.05에서 통계분석하였다. 신생골 면적, 둘레, 직경의 계측치에서 실험군이 대조군보다 통계적으로 유의성있게 높은 수치를 나타내었다 (p $\alpha$ -토코페롤을 주사한 집단에서 골 내부구조가 향상되었고, 확장으로 인한 골형성은 주사한 $\alpha$ -토코페롤 용량에 비례하여 유의성있게 증가되었다. 백서에서 전상악골 봉합부의 확장시 초기 단계에서의 $\alpha$ -토코페롤 주입은 골형성을 촉진하고 유지기간을 단축시킬 수 있을 것이다.


    Objective: The aim of this study was to evaluate the effects of vitamin E ( $\alpha$ -tocopherol) administration on bone formation in response to expansion of the inter-premaxillary suture, in rats, histomorphometrically. Methods: Thirty 50 - 60 day old Wistar rats were separated into five equal groups (one control and four experimental). All groups were subjected to inter-premaxilla expansion with 50-gram of force. Six control animals received saline solution (Group I) and three experimental groups were treated with a single dose of $\alpha$ -tocopherol injected into the inter-premaxillary suture after one day after appliance placement (Group II: 2 mg/kg; Group III: 10 mg/kg; and Group IV: 50 mg/kg). A further group of six animals received three injections of 10 mg/kg $\alpha$ -tocopherol, one each on days 3, 6, and 9 (Group V). Bone formation in the suture was evaluated by bone histomorphometry. Kruskal-Wallis rank and Mann-Whitney U tests were used for statistical evaluation at p


  • 주제어

    비타민 E .   $\alpha$-토코페롤 .   확장 .   조직계측 .   백서.  

  • 참고문헌 (31)

    1. Uysal T, Ustdal A, Sonmez MF, Ozturk F. Stimulation of bone formation by dietary boron in an orthopedically expanded suture in rabbits. Angle Orthod 2009;79:984-90 
    2. Key LL, Ries WL, Taylor RG, Hays BD, Pitzer BL. Oxygenderived free radicals in osteoclasts: the specificity and location of the nitroblue tetrazolium reaction. Bone 1990;11:115-9 
    3. Durak K, Bilgen OF, Kaleli T, Tuncel P, Ozbek R, Turan K. Antioxidant effect of alpha-tocopherol on fracture haematoma in rabbits. J Int Med Res 1996;24:419-24 
    4. Burton GW, Ingold KU. Vitamin E as an in vitro and in vivo antioxidant. Ann N Y Acad Sci 1989;570:7-22 
    5. Graber TM, Vanarsdall RL, Vig KWL. Orthodontics: current principles and techniques. 4th ed. St. Louis: Elsevier Mosby; 2005. p. 257-62 
    6. Arjmandi BH, Juma S, Beharka A, Bapna MS, Akhter M, Meydani SN. Vitamin E improves bone quality in the aged but not in young adult male mice. J Nutr Biochem 2002;13:543-9 
    7. Cope JB, Samchukov ML. Mineralization dynamics of regenerate bone during mandibular osteodistraction. Int J Oral Maxillofac Surg 2001:30:234-42 
    8. Sencimen M, Aydintug YS, Ortakoglu K, Karslioglu Y, Gunhan O, Gunaydin Y. Histomorphometrical analysis of new bone obtained by distraction osteogenesis and osteogenesis by periosteal distraction in rabbits. Int J Oral Maxillofac Surg 2007;36:235-42 
    9. Storey E. Tissue response to the movement of bones. Am J Orthod 1973;64:229-47 
    10. Haas AJ. The treatment of maxillary deficiency by opening the midpalatal suture. Angle Orthod 1965;35:200-17 
    11. Swennen G, Dempf R, Schliephake H. Cranio-facial distraction osteogenesis: a review of the literature. Part II: experimental studies. Int J Oral Maxillofac Surg 2002;31:123-35 
    12. Sawada M, Shimizu N. Stimulation of bone formation in the expanding mid-palatal suture by transforming growth factor-${\beta}_1$ in the rat. Eur J Orthod 1996;18:169-79 
    13. Turan B, Balcik C, Akkas N. Effect of dietary selenium and vitamin E on the biomechanical properties of rabbit bones. Clin Rheumatol 1997;16:441-9 
    14. Mundy GR. Cytokines and growth factors in the regulation of bone remodeling. J Bone Min Res 1993;8:S505-10 
    15. Yilmaz C, Erdemli E, Selek H, Kinik H, Arikan M, Erdemli B. The contribution of vitamin C to healing of experimental fractures. Arch Orthop Trauma Surg 2001;121:426-8 
    16. Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 1990;85:632-9 
    17. Rasband, WS. Image-J. U.S. National Institutes of Health, Bethesda, Maryland, USA, http://rsb.info.nih.gov/ij/, 1997-2008 
    18. Burstone CJ, Shafer WG. Sutural expansion by controlled mechanical stress in the rat. J Dent Res 1959;38:534-40 
    19. Saito S, Shimizu N. Stimulatory effects of low-power laser irradiation on bone regeneration in midpalatal suture during expansion in the rat. Am J Orthod Dentofacial Orthop 1997;111: 525-32 
    20. Ten Cate AR, Freeman E, Dickinson JB. Sutural development: structure and its response to rapid expansion. Am J Orthod 1977;71:622-36 
    21. van Tits LJ, Demacker PN, de Graaf J, Hak-Lemmers HL, Stalenhoef AF. Alpha-tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals. Am J Clin Nutr 2000;71:458-64 
    22. Arjmandi BH, Akhter MP, Chakkalakal D, Khalil DA, Lucas EA, Juma S, et al. Effects of isoflavones, vitamin E, and their combination on bone in an aged rat model of osteopenia. J Bone Min Res 2001;16:S533 
    23. Durak K, Sonmez G, Sarisozen B, Ozkan S, Kaya M, Ozturk C. Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits. J Int Med Res 2003;31:26-30 
    24. G$\ddot {o}$kt$\ddot {u}$rk E, Turgut A, Baycu C, G$\ddot {u}$nal I, Seber S, G$\ddot {u}$lbas Z. Oxygen-free radicals impair fracture healing in rats. Acta Orthop Scand 1995;66:473-5 
    25. Uysal T, Amasyali M, Enhos S, Sonmez MF, Sagdic D. Effect of ED-71, a new active vitamin D analog, on bone formation in an orthopedically expanded suture in rats. a histomorphometric study. Eur J Dent 2009;3:165-72 
    26. Turk C, Halici M, Guney A, Akgun H, Sahin V, Muhtaroglu S. Promotion of fracture healing by vitamin E in rats. J Int Med Res 2004;32:507-12 
    27. Turan B, Can B, Delilbasi E. Selenium combined with vitamin E and vitamin C restores structural alterations of bones in heparin- induced osteoporosis. Clin Rheumatol 2003;22: 432-6 
    28. Hagiwara T, Bell WH. Effect of electrical stimulation on mandibular distraction osteogenesis. J Craniomaxillofac Surg 2000; 28:12-9 
    29. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995;332:305-11 
    30. Eriksen EF, Axelrod DW, Melson F. Bone histology and histomorphometry. In: Bone histomorphometry. New York: Raven Press; 1994. p. 33-8 
    31. Burton GW, Traber MG. Vitamin E: antioxidant activity, biokinetics, and bioavailability. Annu Rev Nutr 1990;10:357-82 
  • 이 논문을 인용한 문헌 (1)

    1. 2010. "Stimulation of bone formation by direct electrical current in an orthopedically expanded suture in the rat" 대한치과교정학회지 = The Korean journal of orthodontics, 40(2): 106~114     

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