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A Fluorenone Alkaloid from Caulophyllum robustum Maxim. with Anti-myocardial Ischemia Activity

Wang, Sicen    (School of Medicine, Xi'an Jiaotong University   ); Wen, Binyu    (School of Medicine, Xi'an Jiaotong University   ); Wang, Na    (School of Medicine, Xi'an Jiaotong University   ); Liu, Juntian    (School of Medicine, Xi'an Jiaotong University   ); He, Langchong    (School of Medicine, Xi'an Jiaotong University  );
  • 초록

    A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustumMaxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.


  • 주제어

    Caulophyllum robustum Maxim.   .   Caulophine .   Anti-myocardial ischemia.  

  • 참고문헌 (26)

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