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가토의 귀에서 무세포성 진피 기질의 이식 방법에 따른 치유 양상
HEALING PATTERNS OF THE ACELLULAR DERMAL MATRIX DEPEND ON GRAFT METHOD IN THE RABBIT EARS

류재영    (전남대학교 치의학전문대학원 구강악안면외과학교실, 전남대학교 치의학연구소   ); 유선열    (전남대학교 치의학전문대학원 구강악안면외과학교실, 전남대학교 치의학연구소  );
  • 초록

    Purpose: The retention of the basement membrane complex, which was the unique feature of the acellular dermal matrix ( $AlloDerm^{(R)}$ ), plays an important role in the normal process of wound healing. The present study was aimed to compare the healing of the acellular dermal matrix according to the graft method in the rabbit ear. Materials and methods: Six mature rabbits weighing about 3.0 kg were used, $10\;{\times}\;5\;mm$ sized subcutaneous pockets were created between the ear skin and the underlying perichondrium. In the control group, the acellular dermal matrix was grafted with the basement membrane facing toward the perichondrium. On the contrary, the acellular dermal matrix was grafted with the basement membrane facing toward the skin side in the experimental group I. In the experimental group II, the acellular dermal matrix was grafted like rolled configuration with basement membrane side in. The grafted site was picked at 3, 7, and 21 days after the graft. Serial sections were processed by H-E stain and examined under light microscopy to assess the healing patterns. Results: There was no distinct volume loss in the gross examination, but resorption was observed from the edge of the acellular dermal matrix in the histological examination. The space of resorption was replaced by the newly formed fibrous tissues and vessels. The inflammatory cells were more increased at 7 days after the graft than the early days. However, inflammation was decreased at 21 days after the graft. Regardless of the graft direction, no differences were observed between the control and the experimental group I in the healing patterns. Conclusion: These results suggest that the acellular dermal matrix can be used simply and effectively without regard to the graft direction as a substitute of autogenous material for repairing soft tissue defect.


  • 주제어

    Acellular dermal matrix .   Graft method .   Healing pattern.  

  • 참고문헌 (17)

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    13. Chetty BV, Boissy RE, Warden GD et al : Basement membrane and fibroblast aberration in blisters at the donor, graft, and spontaneously healed sites in patients with burns. Arch Dermatol 128 : 181, 1992 
    14. Achauer BM, VanderKam VM, Celikoz B et al : Augmentation of facial soft tissue defects with Alloderm dermal graft. Ann Plast Surg 41 : 503, 1998 
    15. Tzikas TL : Lipografting : autologous fat grafting for total facial rejuvenation. Facial Plast Surg 20 : 135, 2004 
    16. Williams SK, Patula VB, Kleinert LB et al : Dual porosity expanded polytetrafluoroethylene for soft-tissue augmentation. Plast Reconstr Surg 115 : 1995, 2005 
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